Autoimmunity after liver transplantation: a frequent event but a rare clinical problem.

abstract：:Post-transplant bone disease is common in solid organ recipients; however, there is limited information on their pre-transplant bone status. We aimed to compare bone mineral density (BMD) in different categories of patients with end-stage organ failure awaiting transplantation (Tx) in Norway. Overall 291 adult patient...

journal_title：Clinical transplantation

authors： Dolgos S,Hartmann A,Isaksen GA,Simonsen S,Bjørtuft Ø,Boberg KM,Bollerslev J

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:The average age of patients undergoing liver transplantation (LT) is consistently increasing. The aim of this case-control study is to evaluate survival and outcome of patients ≥65 yr compared to younger patients undergoing LT. MATERIALS AND METHODS:From 10/00 to 4/08 we performed 330 primary LT, 31 (9.4%...

journal_title：Clinical transplantation

authors： Montalti R,Rompianesi G,Di Benedetto F,Ballarin R,Gerring RC,Busani S,De Pietri L,De Ruvo N,Iemmolo RM,Guerrini GP,Smerieri N,Gerunda GE

更新日期：2010-09-01 00:00:00

abstract：:Tacrolimus is the cornerstone of immunosuppressive therapy after kidney transplantation. Its narrow therapeutic window mandates serum level strict monitoring and dose adjustments to ensure the optimal risk-benefit balance. This observational retrospective study analyzed the effectiveness and safety of conversion from ...

journal_title：Clinical transplantation

authors： Sánchez Fructuoso A,Ruiz JC,Franco A,Diekmann F,Redondo D,Calviño J,Serra N,Aladrén MJ,Cigarrán S,Manonelles A,Ramos A,Gómez G,González Posada JM,Andrés A,Beneyto I,Muñiz AL,Perelló M,Lauzurica R

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:It has been shown that glomerulonephritis (GN) recurrence affects graft survival more than acute rejection. Thus, we assessed allograft survival after biopsy-confirmed diagnosis of acute rejection or recurrent GN in current era of immunosuppression. METHODS:Allograft survival following a biopsy diagnosis of...

journal_title：Clinical transplantation

authors： Singh T,Astor BC,Zhong W,Mandelbrot DA,Maursetter L,Panzer SE

更新日期：2019-12-01 00:00:00

abstract：:Calcineurin inhibitors (CNI) have been commonly used as pivotal immunosuppressive agents to renal transplant recipients and have contributed significantly to improving short-term allograft survival. However, long-term administration of CNI may cause an adverse effect on kidney function, known as chronic nephrotoxicity...

journal_title：Clinical transplantation

authors： Horike K,Takeda A,Yamaguchi Y,Ogiyama Y,Yamauchi Y,Murata M,Kawaguchi T,Suzuki T,Otsuka Y,Inaguma D,Goto N,Watarai Y,Uchida K,Morozumi K

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:As the indications for liver transplantation broaden to include older and more critically ill patients, the likelihood of encountering unsuspected cardiovascular disease increases. PURPOSE:This study examined the frequency, type, and subsequent outcome of intra- and postoperative cardiovascular complication...

journal_title：Clinical transplantation

authors： Dec GW,Kondo N,Farrell ML,Dienstag J,Cosimi AB,Semigran MJ

更新日期：1995-12-01 00:00:00

abstract：AIMS:To evaluate the effect of donor liver resident mesenchymal cells, M2 macrophages on liver graft outcome after living donor liver transplantation. MATERIALS AND METHODS:Seventy donor biopsies were included in the study. Outcomes at day 3, 7, 30, and 180 postliver transplantation were assessed. Mesenchymal stem cel...

journal_title：Clinical transplantation

authors： Nigam N,Bihari C,Lal D,Rastogi A,Kumar S,Pamecha V,Kaur S,Kumar A,Sarin SK

更新日期：2018-03-01 00:00:00

abstract：:Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a cell surface protein, which down-regulates the immune response at CTLA-4/CD28/B7 pathway. We aimed to investigate the influence of the -318 C/T, +49 A/G, -1661 A/G and CT60A/G, and CTLA-4 gene polymorphisms on acute rejection of kidney allograft in Turkish patients. The s...

journal_title：Clinical transplantation

authors： Ruhi Ç,Sallakçi N,Yeğin O,Süleymanlar G,Ersoy FF

更新日期：2015-07-01 00:00:00

abstract：:In recent years, several researchers have unraveled the previously unrecognized effects of granulocyte colony-stimulating factor (G-CSF) on hematopoiesis and the immune cell functions of bone marrow in healthy donors. In human leukocyte antigen-matched or haploidentical transplant settings, available data have establi...

journal_title：Clinical transplantation

authors： Chang YJ,Huang XJ

更新日期：2011-01-01 00:00:00

abstract：:The objective of this meta-analysis was to review the evidence for the use of immune globulin in the prevention of symptomatic cytomegalovirus (CMV) disease in transplant recipients. A computerized search of Medline from 1980 to October 1991 was conducted using the textword "cytomegalo:" and the subheading "prevention...

journal_title：Clinical transplantation

authors： Glowacki LS,Smaill FM

更新日期：1994-02-01 00:00:00

abstract：:We aimed to determine the epidemiology, risk factors, and impact of bacterial infection on pancreatic function after pancreas transplantation. Data for pancreas transplant recipients were retrospectively reviewed between 2000 and 2014 for at least 1 year. We collected and analyzed post-transplant data for bacterial in...

journal_title：Clinical transplantation

authors： Bodro M,Ferrer J,Ricart MJ,Sanclemente G,Linares L,Cervera C,Cofan F,Ventura-Aguiar P,Lopez-Boado MÁ,Marco F,Fuster J,García-Valdecasas JC,Moreno A

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate ...

journal_title：Clinical transplantation

authors： Yagisawa T,Kam I,Chan L,Springer JW,Dunn S

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The pediatric end stage liver disease (PELD) score has been used widely to prioritize children awaiting cadaveric liver transplantation (LTx). To establish the objective parameter for optimal timing of living-related LTx (LRLTx), we have assessed our cases using the PELD score. METHODS:From 1997 to 2002, 24...

journal_title：Clinical transplantation

authors： Kimura T,Hasegawa T,Sasaki T,Shimizu Y,Mushiake S,Fukuzawa M,Okada A

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Elderly patients are the fastest growing population requiring renal replacement therapy. As previous studies have shown a survival benefit of kidney transplantation compared to dialysis for end-stage renal disease, we sought to evaluate if this survival benefit extends to octogenarians. METHODS:This was a s...

journal_title：Clinical transplantation

authors： Ravichandran BR,Sparkes TM,Masters BM,Thomas B,Demehin M,Bromberg JS,Haririan A

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to determine whether the expression of CD25, CD28 and CD38 (which reflects the degree of T-cell activation) by peripheral blood mononuclear cells constitutes a useful means of measuring the immune status of liver transplant recipients. METHODS:Fifty-two patients enrolled in a p...

journal_title：Clinical transplantation

authors： Boleslawski E,BenOthman S,Grabar S,Correia L,Podevin P,Chouzenoux S,Soubrane O,Calmus Y,Conti F

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls. METHODS:Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1...

journal_title：Clinical transplantation

authors： Davis S,Dylewski J,Shah PB,Holmen J,You Z,Chonchol M,Kendrick J

更新日期：2019-01-01 00:00:00

abstract：:The exact mechanism of acute and chronic allograft rejection still remains unclear. The chemokine SDF-1 as mediator of allograft rejection has been under intensive investigation in liver, cardiac and bone marrow transplantation, whereas in renal transplantation, there are no reports about SDF-1 to date. This study was...

journal_title：Clinical transplantation

authors： Hoffmann U,Banas B,Krüger B,Banas M,Bergler T,Böger C,Kammerl M,Obed A,Rümmele P,Segerer S,Riegger GA,Krämer BK

更新日期：2006-11-01 00:00:00

abstract：:Therapeutic living donor nephrectomy is defined as a nephrectomy that is performed as therapy for an underlying medical condition. The patient directly benefits from having their kidney removed, but the kidney is deemed transplantable. The kidney is subsequently used as an allograft for an individual with advanced ren...

journal_title：Clinical transplantation

authors： Dale LA,Silva MV,Sandoval PR,Decastro J,Campenot ES,Ratner LE

更新日期：2019-12-01 00:00:00

abstract：:There is paucity in the data examining the differences in mycophenolate mofetil (MMF) dosing and outcomes among pediatric kidney transplant recipients (PKTX) between races. The aims of this study were as follows (i) to assess whether higher doses of MMF are being utilized in African American (AA) PKTX (ii) to determin...

journal_title：Clinical transplantation

authors： Jensen CJ,Shrivastava S,Taber DJ,Weimert NA,Shatat IF,Orak J,Chavin KD,Baliga PK

更新日期：2011-07-01 00:00:00

abstract：:Hepatitis C is the leading indication for liver transplantation in the USA and recurrence is universal. The impact of preexisting diabetes, new-onset diabetes after transplant (NODAT), and glycemic control on fibrosis progression has not been studied. This retrospective longitudinal cohort study included adult liver r...

journal_title：Clinical transplantation

authors： Morbitzer KA,Taber DJ,Pilch NA,Meadows HB,Fleming JN,Bratton CF,McGillicuddy JW,Baliga PK,Chavin KD

更新日期：2014-08-01 00:00:00

abstract：:A lack of research exploring post-transplant process optimization to reduce readmissions and increasing readmission rates at our center from 2009 to 2013 led to this study, aimed at assessing the effect of patient and process factors on 30-d readmission rates after kidney transplantation. This was a retrospective case...

journal_title：Clinical transplantation

authors： Covert KL,Fleming JN,Staino C,Casale JP,Boyle KM,Pilch NA,Meadows HB,Mardis CR,McGillicuddy JW,Nadig S,Bratton CF,Chavin KD,Baliga PK,Taber DJ

更新日期：2016-07-01 00:00:00

abstract：:The organ shortage is one of the major challenges in the field of organ transplantation, yet the percentage of kidneys procured and discarded prior to transplantation has continued to rise to twenty percent. The causes of organ discard are complex, yet an urgent need exists for collaborative efforts to maximize the ut...

journal_title：Clinical transplantation

authors： Cooper M,Formica R,Friedewald J,Hirose R,O'Connor K,Mohan S,Schold J,Axelrod D,Pastan S

更新日期：2019-01-01 00:00:00

abstract：:ABO-incompatible kidney transplantation (ABO-ILKT) has been reported to have a higher rate of early complications and higher medical costs than ABO-compatible kidney transplantation (ABO-CLKT). We aimed to compare the clinical outcomes, complications, and medical costs between ABO-ILKTs and ABO-CLKTs at 2 years post-t...

journal_title：Clinical transplantation

authors： Kakuta Y,Okumi M,Unagami K,Iizuka J,Takagi T,Ishida H,Tanabe K

更新日期：2019-06-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor (ACEI) has become recognized as agents that have renoprotective effects in the treatment of progressive renal diseases including post-transplant kidneys. Previously we demonstrated the safety and effectiveness of ACEI treatment on the hypertensive proteinuric post-transplant pat...

journal_title：Clinical transplantation

authors： Namba Y,Moriyama T,Kyo M,Oka K,Kokado Y,Shi Y,Imamura R,Ichimaru N,Okuyama A,Takahara S

更新日期：2004-01-01 00:00:00

abstract：:Evaluation of potential kidney transplant recipients is important to identify and treat conditions that may influence graft or patient survival after transplantation. We performed a single-center, observational cohort study to determine whether pretransplant midodrine use influences outcomes after kidney transplantati...

journal_title：Clinical transplantation

authors： Pottebaum AA,Hagopian JC,Brennan DC,Gharabagi A,Horwedel TA

更新日期：2018-09-01 00:00:00

abstract：:In France, liver grafts which have been refused by at least five centers are proposed as rescue allocation (RA). The aim of this study is to clarify the feasibility and safety of RA grafts in liver transplantation (LT). Short- and long-term outcomes of patients who received RA grafts (RA group) were compared with thos...

journal_title：Clinical transplantation

authors： Kitano Y,Allard MA,Nakada S,Beghdadi N,Karam V,Vibert E,Sa Cunha A,Castaing D,Cherqui D,Baba H,Adam R

更新日期：2020-07-19 00:00:00

abstract：:Clinical small bowel transplantation (SBTx) has been associated with a high rate of infectious complications. Laparotomy, preservation injury, abnormal motility, lymphatic disruption, aberrant systemic venous drainage, rejection and antibiotic therapy could all be implicated in the etiology of these complications. In ...

journal_title：Clinical transplantation

authors： Cicalese L,Sileri P,Asolati M,Rastellini C,Abcarian H,Benedetti E

更新日期：2000-12-01 00:00:00

abstract：:Cytokines, produced by both the recipient and the newly vascularized allograft, are central mediators in the inflammatory response to allografted tissue. This study examines the relationship between pre- and intraoperative levels of TNF, IL-1, IL-6, and IL-8 and hepatic allograft function in the early postoperative pe...

journal_title：Clinical transplantation

authors： Boros P,Suehiro T,Curtiss S,Sheiner P,Emre S,Guy S,Schwartz ME,Miller CM

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the efficacy of lamivudine (LAM) monoprophylaxis for patients with non-replicating hepatitis B virus (HBV) infection at orthotopic liver transplantation (OLT). METHODS:Among 128 liver recipients with HBV infection between 1994 and 2004 transplanted at our institution, 6...

journal_title：Clinical transplantation

authors： Yoshida H,Kato T,Levi DM,Regev A,Madariaga JR,Nishida S,Martinez EJ,Schiff ER,Omata M,Tzakis AG

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:With the growing numbers of liver transplant recipients, it is increasingly important to understand the risks of de novo malignancy after liver transplantation. AIM:To characterize the incidence of de novo malignancy after liver transplantation compared with a control non-transplant population. METHODS:We ...

journal_title：Clinical transplantation

authors： Chatrath H,Berman K,Vuppalanchi R,Slaven J,Kwo P,Tector AJ,Chalasani N,Ghabril M

更新日期：2013-07-01 00:00:00