Abstract：
:Of 10 000 compounds tested for tissue schizontocidal activity in a Plasmodium gallinaceum-chick model, 157 were also tested in a definitive mouse test (DMT) and 277 in a rhesus monkey test (RMT). The results in the avian model were 78% and 55% in agreement with those of the DMT and RMT, respectively. This result is not as good as that for a tissue schizontocidal mouse screen previously reported, which showed 93% and 80% agreement with DMT and RMT, respectively. More than three-quarters of the compounds tested in DMT and RMT were 8-aminoquinolines, a chemical class known to have tissue schizontocidal activity.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Kinnamon KE,Davidson DE Jr,Rane DSsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
119-23issue
1eissn
0042-9686issn
1564-0604journal_volume
63pub_type
杂志文章abstract：:Takahashi reported in 1962 that his kaolin-agglutination test (KAT), using the phosphatide fraction of Mycobacterium tuberculosis as antigen, was capable of detecting specific antibodies in sera from patients with pulmonary tuberculosis, and that the test could differentiate between active and inactive disease.The pre...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:There was a dramatic rise in the prevalence of urinary schistosomiasis around Volta Lake within a year of its full impoundment in 1968. Research was undertaken to investigate the epidemiology of the disease in preparation for a control programme. The interplay of three factors-age, sex, and ethnic affiliation-largely ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Mycotoxicoses are diseases caused by mycotoxins, i.e. secondary metabolites of moulds. Although they occur more frequently in areas with a hot and humid climate, favourable for the growth of moulds, they can also be found in temperate zones. Exposure to mycotoxins is mostly by ingestion, but also occurs by the dermal ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:Bringing together various disease-specific guidelines for sick children, WHO and UNICEF have developed an Integrated Management of Childhood Illness (IMCI) algorithm, one component of which (assess and classify) was tested in the outpatient department of a rural district hospital in western Uganda. Children aged 2-59 ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:A two-year study was undertaken to establish the incidence and possible viral etiology of acute respiratory diseases among the child population of a shanty town in Rio de Janeiro, Brazil. The results demonstrated that nearly half of all the illnesses seen were respiratory infections, 10% of them affecting the lower re...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Low back pain is the leading cause of years lived with disability globally. In 2018, an international working group called on the World Health Organization to increase attention on the burden of low back pain and the need to avoid excessively medical solutions. Indeed, major international clinical guidelines now recog...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.18.226050
更新日期：2019-06-01 00:00:00
abstract：:A critical review is made of the present knowledge of the etiology of neoplasms of the haematopoietic system in experimental animals and man. Genetic factors play a dominant role in the origin of leukaemias in mice. A Mendelian interpretation of the data is excluded and several genes appear to be involved in susceptib...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:Histochemical staining methods for acid phosphatase were used to study the differences among microfilariae of various West African strains of Onchocerca volvulus in both forest and Sudan-savanna onchocerciasis zones. The results have shown statistically significant differences in the staining patterns of microfilarial...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:To assess its potential applications in plague surveillance and control programmes, an enzyme-linked immunosorbent assay (ELISA) that captures the specific Yersinia pestis F1 antigen was used to determine the amounts of this antigen present in samples of blood and spleens from laboratory rats with acute plague, in the...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:In 1963 the World Health Organization established a system for the collection and distribution of information on viruses. By 1973 laboratories in 45 countries were participating in this scheme. The present study is an analysis of the reports on adenovirus, influenza viruses A, B, and C, parainfluenza virus, respirator...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:Twenty-five strains of poliomyelitis virus isolated from paralytic cases in the Netherlands, Belgium, and Germany were classified either by testing resistance of immunized monkeys, or by neutralization. Seventeen strains (68%) were classified as type 1, 7 (28%) as type 2, and 1 (4%) as type 3. Strains of type 2 are pr...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
abstract：:Studies were conducted each month for one year to determine the cercarial-incubation periods of Schistosoma haematobium and Schistosoma bovis in Bulinus truncatus for different months of infection. The snails were kept in outdoor aquaria in order to simulate the natural temperature conditions in the endemic bilharzias...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:This article describes how to estimate the discharge of water in rivers and streams by means of weirs, current meters and floats, and how to calculate and administer doses of DDT for the treatment of simuliid-infested waters. ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1957-01-01 00:00:00
abstract：:Catchy music spots and engaging storylines can help to convey important public health messages, but do they improve our health? Gary Humphreys and Fiona Fleck report. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.15.020715
更新日期：2015-07-01 00:00:00
abstract：:Development of resistance to chloroquine in rodent malaria is inhibited by giving this compound together with a potentiating mixture of pyrimethamine and sulfadoxine but this does not prevent the development of resistance to the last two compounds. The use of drug mixtures should be explored as a means of "protecting"...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:This paper presents estimates of the prevalence of visual impairment and its causes in 2002, based on the best available evidence derived from recent studies. Estimates were determined from data on low vision and blindness as defined in the International statistical classification of diseases, injuries and causes of d...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：/S0042-96862004001100009
更新日期：2004-11-01 00:00:00
abstract：:The efficacy of BCG vaccine in preventing the clinical manifestations of leprosy in a tuberculosis-free area of Papua New Guinea is reported. Between 1963 and 1966 a total of 5356 subjects, randomized to receive BCG or saline inoculations, were examined for leprosy before the vaccination and surveillance was continued...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To determine the direct medical costs of type 1 diabetes mellitus (T1DM) to the National Brazilian Health-Care System (NBHCS) and quantify the contribution of each individual component to the total cost. METHODS:A retrospective, cross-sectional, nationwide multicentre study was conducted between 2008 and 201...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,多中心研究
doi：10.2471/BLT.12.110387
更新日期：2013-06-01 00:00:00
abstract：:WHO's reference protocol for post-exposure rabies vaccination advises five intramuscular injections on days 0, 3, 7, 14, and 30; in addition, rabies immunoglobulins (RIG) must be given to serious cases of exposure (grade III severity). Some studies indicate that these immunoglobulins suppress the immunogenicity of rab...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To determine whether vaccination against measles in a population with sustained high vaccination coverage and relatively low child mortality reduces overall child mortality. METHODS:In April and May 2000, a population-based, case-control study was conducted at Ballabgarh (an area in rural northern India). El...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:An extensive outbreak of Hong Kong influenza occurred in the USA during the autumn and early winter of 1968-69. Introduction and seeding of the virus occurred in September and early October as individuals returned from the Far East. Civilian outbreaks did not develop until late October and November. By 28 December, al...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1969-01-01 00:00:00
abstract：:Until about 10 years ago heparin was prepared from ox lungs and was regarded as a homogeneous polymer (of a sulfated mucopolysaccharide) with a relatively constant biological activity of about 100 IU/mg. The mucus and mucosa of the intestine of hog, sheep and ox have now become the main industrial source of bulk start...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:The results of comparative assays have revealed considerable variation in the potencies of tetanus toxoids produced in different laboratories. Some manufacturers are able consistently to produce toxoids high in potency; others are not able to do so. While further work is required in order to correlate the animal assay...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：:Ten male subjects from a region of the state of Pará, Brazil, where malaria is endemic received a single oral dose of 1000 mg mefloquine. The plasma levels of the drug and of its metabolite, 2,8-bis(trifluoromethyl)-4-quinolinecarboxylic acid, were determined densitometrically on thin-layer chromatography plates. The ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The minimal inhibitory concentration (MIC) values of penicillin, ampicillin, tetracycline, chloramphenicol, and streptomycin for 500 gonococcal strains were studied for product-moment coefficient correlations. The strains were isolated from male patients with acute gonococcal urethritis attending the Venereal Disease ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:In the current information age, research synthesis is a particularly useful tool for keeping track of scientific research and making sense of the large volumes of frequently conflicting data derived from primary studies. The Cochrane Collaboration is a global initiative "to help people make well-informed decisions abo...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2004-10-01 00:00:00
abstract：:Immunity in meningococcal diseases has been inadequately studied and, until now, most attempts at serotherapy and immunization against meningococcal meningitis have been unsuccessful. To ascertain the status of immunity among children at greatest risk of contracting the disease, 267 serum specimens from healthy childr...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：PROBLEM:As national antiretroviral treatment (ART) programmes scale-up, it is essential that information is complete, timely and accurate for site monitoring and national planning. The accuracy and completeness of reports independently compiled by ART facilities, however, is often not known. APPROACH:This study assess...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.07.044685
更新日期：2008-04-01 00:00:00
abstract：:In a community study during a reference period of 1 year, 192 cases of jaundice were detected in an urban population of 69,440 in Alwar, Rajasthan. Detected by paramedics and confirmed by physicians, these cases gave an annual incidence of 2.76 (95% CI: 2.37-3.15) per 1000 population. At least one of these patients di...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Strains of Vibrio cholerae-1156 from various parts of the world-were examined by standardized antibiotic sensitivity tests in one centre, to determine the global incidence of antibiotic resistance in this organism and to assess the extent to which differences in methods of sensitivity testing might be responsible for ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
