Asymmetric catalysis with short-chain peptides.

Abstract:

:Within this review article we describe recent developments in asymmetric catalysis with peptides. Numerous peptides have been established in the past two decades that catalyze a wide variety of transformations with high stereoselectivities and yields, as well as broad substrate scope. We highlight here catalytically active peptides, which have addressed challenges that had thus far remained elusive in asymmetric catalysis: enantioselective synthesis of atropoisomers and quaternary stereogenic centers, regioselective transformations of polyfunctional substrates, chemoselective transformations, catalysis in-flow and reactions in aqueous environments.

journal_name

Curr Opin Chem Biol

authors

Lewandowski B,Wennemers H

doi

10.1016/j.cbpa.2014.09.011

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

40-6

eissn

1367-5931

issn

1879-0402

pii

S1367-5931(14)00123-9

journal_volume

22

pub_type

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