pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity.

abstract：:Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission, inhibit early HIV-1 replication, stimulate adaptive immunity and enable spe...

journal_title：Vaccine

authors： Lehner T,Wang Y,Pido-Lopez J,Whittall T,Bergmeier LA,Babaahmady K

更新日期：2008-06-06 00:00:00

abstract：BACKGROUND:MenB-4C (Bexsero®) is a multicomponent serogroup B meningococcal vaccine. For vaccine licensure, efficacy was inferred from serum bactericidal antibody (SBA) against three antigen-specific indicator strains. The bactericidal role of antibody to the fourth vaccine antigen, Neisserial Heparin binding antigen (...

journal_title：Vaccine

authors： Partridge E,Lujan E,Giuntini S,Vu DM,Granoff DM

更新日期：2017-07-24 00:00:00

abstract：:Lassa virus (LASV) causes a severe hemorrhagic fever endemic throughout western Africa. Because of the ability to cause lethal disease in humans, limited treatment options, and potential as a bioweapon, the need for vaccines to prevent LASV epidemic is urgent. However, LASV vaccine development has been hindered by the...

journal_title：Vaccine

authors： Li Q,Liu Q,Huang W,Wu J,Nie J,Wang M,Zhao C,Zhang L,Wang Y

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Since the introduction of mumps-containing vaccines (MuCV) in 1995 in Beijing, two-dose MuCV vaccination policy has been used, with the 1st and 2nd doses given at 18 months and 6 years of age, respectively. METHODS:Mumps epidemiology during 2005-2016 was described using surveillance data. Vaccine effectiven...

journal_title：Vaccine

authors： Ma R,Lu L,Zhou T,Pan J,Chen M,Pang X

更新日期：2018-05-03 00:00:00

abstract：:A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eve...

journal_title：Vaccine

authors： Palacpac NM,Arisue N,Tougan T,Ishii KJ,Horii T

更新日期：2011-08-11 00:00:00

abstract：:The necessity of avoiding the use of animals in vaccine potency testing has been widely recognized. The repeatability and reproducibility of the Expected Percentage of Protection (EPP) as a serological potency surrogate for A24 Cruzeiro foot-and-mouth disease virus (FMDV) strain was assessed, and compared with the res...

journal_title：Vaccine

authors： Robiolo B,La Torre J,Maradei E,Beascoechea CP,Perez A,Seki C,Smitsaart E,Fondevila N,Palma E,Goris N,De Clercq K,Mattion N

更新日期：2010-08-31 00:00:00

abstract：:A conjugate vaccine against meningococcus A and C was prepared using the non-toxic mutant of diphtheria toxin CRM 197 as a carrier protein. Capsular polysaccharides of Neisseria meningitidis group A and C were hydrolysed and the resulting oligosaccharides were then coupled to CRM 197 in order to obtain conjugates with...

journal_title：Vaccine

authors： Costantino P,Viti S,Podda A,Velmonte MA,Nencioni L,Rappuoli R

更新日期：1992-01-01 00:00:00

abstract：:In recent years, collaborations often between mathematical and computational biologists and scientists in the World Health Organization (WHO) global influenza surveillance network, have resulted in a number of mathematical and computational advances including: increasing the resolution at which antigenic surveillance ...

journal_title：Vaccine

authors： Smith DJ

更新日期：2003-05-01 00:00:00

abstract：:ChimeriVax is a live, attenuated recombinant virus constructed from yellow fever (YF) 17D in which the envelope protein genes of YF 17D are replaced with the corresponding genes of another flavivirus. A ChimeriVax vaccine was developed against Japanese encephalitis (JE). A randomized, double-blind, outpatient study wa...

journal_title：Vaccine

authors： Monath TP,McCarthy K,Bedford P,Johnson CT,Nichols R,Yoksan S,Marchesani R,Knauber M,Wells KH,Arroyo J,Guirakhoo F

更新日期：2002-01-15 00:00:00

abstract：:Dengue is a major infectious disease that affects people living in tropical and subtropical regions around the world. The causative agents are dengue virus serotype 1, 2, 3, and 4 (DENV1, 2, 3, and 4). Developing a vaccine for dengue is a high priority for public health, but traditional methods have faced numerous obs...

journal_title：Vaccine

authors： Pang X,Guo Y,Zhou Y,Fu W,Gu X

更新日期：2014-06-24 00:00:00

abstract：:The continuously increasing demand for potent and safe vaccines and the intensifying economic pressure on health care systems underlines the need for further optimization of vaccine manufacturing. Here, we focus on downstream processing of human influenza vaccines, investigating the purification of serum-free cell cul...

journal_title：Vaccine

authors： Fischer LM,Wolff MW,Reichl U

更新日期：2018-05-24 00:00:00

abstract：:The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine may be influenced by the priming effect of previous influenza vaccinations or exposure to antigenically related influenza viruses. The current study examines the immunoge...

journal_title：Vaccine

authors： Wang S,Parker C,Taaffe J,Solórzano A,García-Sastre A,Lu S

更新日期：2008-07-04 00:00:00

abstract：BACKGROUND:In January 2015, Tajikistan introduced the monovalent rotavirus vaccine into the national immunization program. Our objective was to estimate pre-vaccine burden of rotavirus-associated hospitalizations in children <5 years of age in Tajikistan. METHODS:During January 2013-December 2014, active surveillance ...

journal_title：Vaccine

authors： Nazurdinov AB,Azizov ZA,Tishkova F,Turkov SM,Daniels DS,Leshem E

更新日期：2018-12-14 00:00:00

abstract：:Prior to routine immunisation, Haemophilus influenzae serotype b (Hib) was a major cause of serious bacterial infections, particularly in young children. In the United Kingdom, introduction of the Hib conjugate vaccine into the national childhood immunisation schedule has led to a sustained decline in invasive Hib dis...

journal_title：Vaccine

authors： Townsend K,Ladhani SN,Findlow H,Borrow R

更新日期：2014-09-29 00:00:00

abstract：:Delivery of antigens to antigen presenting cell surface receptors represents a promising strategy to improve immune response to weak immunogenic antigens. We have analyzed the potential of porcine sialoadhesin (Sn) and CD163 as antigen targeting receptors using mouse Igs as surrogate antigens. Sn and CD163 are two end...

journal_title：Vaccine

authors： Poderoso T,Martínez P,Álvarez B,Handler A,Moreno S,Alonso F,Ezquerra Á,Domínguez J,Revilla C

更新日期：2011-06-24 00:00:00

abstract：:The burden of influenza in children is increasingly appreciated; some middle-income countries are considering support for influenza vaccine programs. To support decision-making, methods to estimate the potential impact of proposed programs are needed. Using Thailand as a case-study, we present a model that uses survei...

journal_title：Vaccine

authors： Dawood FS,Fry AM,Muangchana C,Sanasuttipun W,Baggett HC,Chunsuttiwat S,Maloney SA,Simmerman JM

更新日期：2011-06-10 00:00:00

abstract：:Little is known of men's knowledge of cervical cancer and its links with human papillomavirus (HPV), or of their attitudes and beliefs about HPV vaccination. This is despite men's sexual behaviour contributing to HPV transmission and their potential role in deciding whether their children are vaccinated against HPV. T...

journal_title：Vaccine

authors： Pitts M,Smith A,Croy S,Lyons A,Ryall R,Garland S,Wong ML,Hseon TE

更新日期：2009-05-14 00:00:00

abstract：:Neonatal infection with hepatitis B virus carries a very high risk of resulting in a persistent infection. Babies born to hepatitis B carrier mothers are at risk of infection through exposure to blood and body fluids during birth. These 'at risk' babies can only be identified through screening of all mothers during pr...

journal_title：Vaccine

authors： Boxall E

更新日期：1998-11-01 00:00:00

abstract：:Confidence in vaccine safety is critical to national immunization strategies and to global public health. To meet the Millenium Development Goals, and buoyed by the success of new vaccines produced in developing countries, the World Health Organization has been developing a strategy to establish a global system for ef...

journal_title：Vaccine

authors： Graham JE,Borda-Rodriguez A,Huzair F,Zinck E

更新日期：2012-07-13 00:00:00

abstract：:Polymeric nanoparticles (NPs) of poly (lactic-co-glycolic) acid (PLGA) possess adjuvant properties. To date, there are few studies exploring their application as antigen carriers for vaccination of fish. This study presents a preclinical assessment of the early innate and adaptive immune responses in Atlantic salmon f...

journal_title：Vaccine

authors： Fredriksen BN,Sævareid K,McAuley L,Lane ME,Bøgwald J,Dalmo RA

更新日期：2011-10-26 00:00:00

abstract：:The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we sh...

journal_title：Vaccine

authors： Premenko-Lanier M,Rota P,Rhodes G,Bellini W,McChesney M

更新日期：2004-01-26 00:00:00

abstract：:Sweden was the first country in the world to introduce a two-dose programme of vaccination against measles, mumps and rubella with a combined vaccine (MMR). It was commenced in 1982 and the vaccination was carried out at the ages of 18 months and 12 years. In 1992-93 the first age-group vaccinated at 18 months reached...

journal_title：Vaccine

authors： Broliden K,Abreu ER,Arneborn M,Böttiger M

更新日期：1998-01-01 00:00:00

abstract：:The world is facing the rising emergency of SARS-CoV-2. The outbreak of COVID-19 has caused a global public health and economic crisis.Recent epidemiological studies have shown that a possible association of BCG vaccination program with decreased COVID-19-related risks, suggesting that BCG may provide protection again...

journal_title：Vaccine

authors： Tomita Y,Sato R,Ikeda T,Sakagami T

更新日期：2020-09-22 00:00:00

abstract：:Vaccination is an effective strategy to prevent pneumococcal diseases. Currently, licensed vaccines include the pneumococcal polysaccharide vaccine (PPSV) and the pneumococcal conjugate vaccine (PCV), which target some of the most common of the 94 serotypes of S. pneumoniae based on their capsular composition. However...

journal_title：Vaccine

authors： Nagai K,Domon H,Maekawa T,Hiyoshi T,Tamura H,Yonezawa D,Habuka R,Saitoh A,Terao Y

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Micrurus venoms contain two main groups of toxic protein components: short-chain α-neurotoxins (SNtx) and phospholipases type A2 (PLA2). In North America, generally, the Micrurus venoms have low abundance of SNtx compared to that of PLA2s; however, both are highly toxic to mammals, and consequently both can ...

journal_title：Vaccine

authors： Archundia IG,de la Rosa G,Olvera F,Calderón A,Benard-Valle M,Alagón A,Corzo G

更新日期：2021-02-05 00:00:00

abstract：:Clinical and post-licensure data have demonstrated that AS03-adjuvanted inactivated split virion vaccines, many with reduced antigen content, are effective against influenza infection. The objective of this review is to provide a comprehensive assessment of the safety of trivalent seasonal, monovalent pre-pandemic and...

journal_title：Vaccine

authors： Cohet C,van der Most R,Bauchau V,Bekkat-Berkani R,Doherty TM,Schuind A,Tavares Da Silva F,Rappuoli R,Garçon N,Innis BL

更新日期：2019-05-21 00:00:00

abstract：INTRODUCTION:Serotype replacement after the introduction of seven-valent pneumococcal conjugate vaccine (PCV7) and the future availability of multivalent PCVs prompted the listing of invasive pneumococcal disease (IPD) as a notifiable disease in Taiwan in October 2007. Here, we report the national surveillance results....

journal_title：Vaccine

authors： Chiang CS,Chen YY,Jiang SF,Liu DP,Kao PH,Teng HJ,Kuo TL,Yao SM,Tseng LR,Wang YL,Wu HS,Chang FY,Lin TY

更新日期：2014-06-05 00:00:00

abstract：:The inflexibility of existing serological techniques for detection of rabies in surveillance constrains the benefit to be gained from many current control strategies. We analysed 304 serum samples from Tanzanian dogs for the detection of rabies antibodies in a pseudotype assay using lentiviral vectors bearing the CVS-...

journal_title：Vaccine

authors： Wright E,McNabb S,Goddard T,Horton DL,Lembo T,Nel LH,Weiss RA,Cleaveland S,Fooks AR

更新日期：2009-11-27 00:00:00

abstract：:Salmonella spp. are facultative intracellular pathogens causing localised or systemic infections, in addition to a chronic asymptomatic carrier state. They are of worldwide economic and public health significance. In poultry, which represent important sources of cheap protein throughout the world, fowl typhoid and pul...

journal_title：Vaccine

authors： Zhang-Barber L,Turner AK,Barrow PA

更新日期：1999-06-04 00:00:00

abstract：:We previously developed a dengue tetravalent DNA vaccine that can induce neutralizing antibodies against four dengue viruses in mice. Here, we demonstrated that immunogenicity of our tetravalent vaccine is synergistically increased in mice by co-immunization with dengue type 2 virus (DENV2) subviral extracellular part...

journal_title：Vaccine

authors： Imoto J,Konishi E

更新日期：2007-01-22 00:00:00