Abstract:
:A new technique is described for the autoradiographic determination of regional brain glucose metabolism employing 14C labeled glucose as substrate and measurement principles previously described for whole brain. Regional glucose values correlate closely with those reported for the 14C-deoxyglucose technique. The method has the advantages of 1) a much shorter experimental period, 2) a relatively simple mathematical treatment, and 3) the utilization of the actual, fully metabolizable substance itself, glucose, as the label. In addition to normal rats, regional values are reported for 20 individual brain areas of rats in bicuculline induced status epilepticus, rats intoxicated with ammonium and rats anesthetized with pentobarbital sodium or ketamine.
journal_name
Strokejournal_title
Strokeauthors
Hawkins R,Hass WK,Ransohoff Jdoi
10.1161/01.str.10.6.690subject
Has Abstractpub_date
1979-11-01 00:00:00pages
690-703issue
6eissn
0039-2499issn
1524-4628journal_volume
10pub_type
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