Sympathetic control of the cerebral vasculature in humans.

Abstract:

BACKGROUND AND PURPOSE:The role of the sympathetic nervous system in cerebral autoregulation remains poorly characterized. We examined cerebral blood flow responses to augmented arterial pressure oscillations with and without sympathetic blockade and compared them with responses in the forearm circulation. METHODS:An oscillatory lower body negative pressure of 40 mm Hg was used at 6 frequencies from 0.03 to 0.08 Hz in 11 healthy subjects with and without alpha-adrenergic blockade by phentolamine. RESULTS:Sympathetic blockade resulted in unchanged mean pressure and cerebral flow. The transfer function relationship to arterial pressure at frequencies >0.05 Hz was significantly increased in both the cerebral and brachial circulations, but the coherence of the relation remained weak at the lowest frequencies in the cerebral circulation. CONCLUSIONS:Our data demonstrate a strong, frequency-dependent role for sympathetic regulation of blood flow in both cerebral and brachial circulations. However, marked differences in the response to blockade suggest the control of the cerebral circulation at longer time scales is characterized by important nonlinearities and relies on regulatory mechanisms other than the sympathetic system.

journal_name

Stroke

journal_title

Stroke

authors

Hamner JW,Tan CO,Lee K,Cohen MA,Taylor JA

doi

10.1161/STROKEAHA.109.557132

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

102-9

issue

1

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.109.557132

journal_volume

41

pub_type

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