Abstract:
:The functional maturation of cuneate neurons was studied using reproducible tactile stimulation procedures and quantitative assessment of coding capacities in anesthetized (N2O/O2 plus barbiturate infusion) or decerebrate cats from six different age groups; neonatal (1-5 days), 10-15, 25-30, 55-63, and 83-90 days, and an adult group. Cuneate neurons were distinguished from input fibers to the nucleus on criteria of spike configuration and time course and on response profiles. Extracellular spike durations underwent a progressive shortening with age, reaching the adult range at approximately 3 mo when background activity levels also reached maturity. Despite an increase in conduction-path length, response latencies decreased to adult values by 25-30 days of age, presumably reflecting the increased conduction velocity in the input fibers. In each age group three functional classes of neurons responsive to tactile stimulation of the footpads were identifiable. One consisted of slowly adapting neurons whose stimulus-response relations resembled those of the adult in responsiveness and dynamic range by 25-30 days postnatal age. The remaining neurons were purely dynamically sensitive, but among them two classes could be distinguished by their differential sensitivity to cutaneous vibration, one receiving rapidly adapting (RA) fiber input the other pacinian corpuscle (PC) input. The combined bandwidth of vibration sensitivity in dynamically sensitive cuneate neurons expands from approximately 5-300 Hz in the neonate to the mature range of 5-1,000 Hz by 1 mo of age. The PC class of cuneate neurons showed an upward shift in peak sensitivity from 30-200 Hz in the neonate to 100-300 Hz at 10-15 days, reaching adult values of 200-600 Hz by 25-30 days. Over this period absolute thresholds dropped by an order of magnitude at 200-500 Hz reflecting the threshold trends in primary PC fibers. During the first 1-2 postnatal months, the capacity of cuneate PC neurons to signal information in a pattern code about vibration frequencies around 300 Hz is restricted because of poor phase locking and low responsiveness, which preclude an impulse periodicity reflecting the vibratory frequency.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Connor KM,Ferrington DG,Rowe MJdoi
10.1152/jn.1984.52.1.86subject
Has Abstractpub_date
1984-07-01 00:00:00pages
86-98issue
1eissn
0022-3077issn
1522-1598journal_volume
52pub_type
杂志文章abstract::Animals and human beings sense and react to real/potential dangerous stimuli. However, the supraspinal mechanisms relating noxious sensing and nocifensive behavior are mostly unknown. The collateralization and spatial organization of interrelated neurons are important determinants of coordinated network function. Here...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00603.2015
更新日期:2016-01-01 00:00:00
abstract::The neuronal mechanisms that contribute to tactile perception were studied using single-unit recordings from the cutaneous hand representation of primate primary (S1) and secondary (S2) somatosensory cortex. This study followed up on our recent observation that S1 and S2 neurons developed a sustained change in dischar...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91121.2008
更新日期:2009-05-01 00:00:00
abstract::Locusts have two large collision-detecting neurons, the descending contralateral movement detectors (DCMDs) that signal object approach and trigger evasive glides during flight. We sought to investigate whether vision for action, when the locust is in an aroused state rather than a passive viewer, significantly alters...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01055.2007
更新日期:2008-08-01 00:00:00
abstract::Endotoxin-induced uveitis (EIU) is commonly used in animals to mimic ocular inflammation in humans. Although the peripheral aspects of EIU have been well studied, little is known of the central neural effects of anterior eye inflammation. EIU was induced in male rats by endotoxin or lipopolysaccharide (LPS, 1 mg/kg ip...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00616.2005
更新日期:2005-12-01 00:00:00
abstract::PSD-95-like, disc-large (DLG) family membrane-associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we show that the protot...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00262.2013
更新日期:2014-02-01 00:00:00
abstract::The hypothesis that gamma-band oscillations are related to the representation of an environmental scene in the cerebral cortex after binding of corresponding perceptual elements is currently under discussion. One question is how the sensory system reacts to a fast change in the scene if perceptual elements are rigidly...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00469.2005
更新日期:2005-12-01 00:00:00
abstract::We studied the effects of horizontal smooth pursuit on the ocular responses to brief vertical perturbations of textured backgrounds in humans. When the subject was fixating on a stationary target, a brief vertical perturbation of the background elicited a small tracking response. When the subject was pursuing a target...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00430.2009
更新日期:2009-09-01 00:00:00
abstract::1. In a brain stem slice preparation, we recorded glutamatergic excitatory postsynaptic currents (EPSCs) in hypoglossal motoneurons (HMs) evoked by extracellular stimulation in the reticular formation just ipsilateral to the hypoglossal motor nucleus (n. XII). Serotonin (5-HT) inhibited glutamatergic synaptic transmis...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.2.799
更新日期:1996-08-01 00:00:00
abstract::To program a goal-directed response in the presence of acoustic reflections, the audio-motor system should suppress the detection of time-delayed sources. We examined the effects of spatial separation and inter-stimulus delay on the ability of human listeners to localize a pair of broadband sounds in the horizontal pl...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00184.2020
更新日期:2020-12-30 00:00:00
abstract::One of the critical factors in determining network behavior of neurons is the influence of local circuit connections among interneurons. The short-term synaptic plasticity and the subtype of presynaptic calcium channels used at local circuit connections of inhibitory interneurons in CA1 were investigated using dual wh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00831.2010
更新日期:2011-03-01 00:00:00
abstract::Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists block...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01228.2004
更新日期:2005-06-01 00:00:00
abstract::We have used the rat hippocampal slice preparation as a model system for studying the epileptogenic consequences of a reduction in neuronal Na+-K+ pump activity. The cardiac glycosides (CGs) strophanthidin and dihydroouabain were used to inhibit the pump. These drugs had readily reversible effects, provided they were ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.2.496
更新日期:1987-02-01 00:00:00
abstract::1. Whole-cell patch-clamp recordings of excitatory postsynaptic currents (EPSCs) were made from guinea pig hippocampal CA1 pyramidal cells. The sensitivity of paired pulse facilitation (PPF) and EPSC variance to changes in synaptic transmission was investigated and the results were compared with the changes in these p...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.70.4.1451
更新日期:1993-10-01 00:00:00
abstract::According to Alexander's law (AL), the slow phase velocity of nystagmus of vestibular origin is dependent on horizontal position, with lower velocity when gaze is directed in the slow compared with the fast phase direction. Adaptive changes in the velocity-to-position neural integrator are thought to cause AL. Althoug...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90381.2008
更新日期:2008-12-01 00:00:00
abstract::1. Inhibitors of extracellular carbonic anhydrase (CAo) offer much promise as diagnostic tools in the study of the synaptic basis of activity-induced alkaline transients in the brain. However, most of the present information related to the effects of CAo blockers in nervous tissue comes from experiments that involve s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.2.633
更新日期:1995-08-01 00:00:00
abstract::1. A method for adapting a standard stereotaxic frame for use with neonatal rats as young as postnatal day 1 (PD 1) was devised, and single-unit extracellular recordings were obtained from neurons in the locus ceruleus (LC) in urethan-anesthetized rats during different stages in development from PD 1 to PD 34. 2. The ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.58.3.510
更新日期:1987-09-01 00:00:00
abstract::Nigrostriatal dopamine denervation plays a major role in basal ganglia circuitry disarray and motor abnormalities of Parkinson's disease (PD). Studies in rodent and primate models have revealed that striatal projection neurons, namely, medium spiny neurons (MSNs), increase the firing frequency. However, their activity...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00910.2014
更新日期:2015-03-01 00:00:00
abstract::Rack and Westbury showed that low-frequency asynchronous stimulation of a muscle produces greater force compared with synchronous stimulation. This study tested the hypothesis that the difference results from the dynamic stretch of the common elastic elements. In eight anesthetized cats, the soleus was attached to a s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01304.2005
更新日期:2006-09-01 00:00:00
abstract::Controlled whisker stimulation and single-unit recordings were used to elucidate response transformations that occur during the processing of tactile information from ventral posterior medial thalamus (VPM) through cortical columns in the rat whisker/barrel cortex. Whiskers were either deflected alone, using punctate ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.4.1808
更新日期:1999-10-01 00:00:00
abstract::Voltage-gated Na+ channels (VGSC) are transmembrane proteins that are essential for the initiation and propagation of action potentials in neuronal excitability. Because neurons express a mixture of Na+ channel isoforms and protein kinase C (PKC) isozymes, the nature of which channel is being regulated by which PKC is...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00676.2003
更新日期:2004-04-01 00:00:00
abstract::1. Excitatory postsynaptic currents (EPSCs) in parasympathetic preganglionic neurons (PGNs) were examined by the use of the whole cell patch-clamp recording technique in slice preparations of the neonatal rat lumbosacral spinal cord. Synaptic responses were evoked in PGNs by extracellular stimulation of a neighboring ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.1.215
更新日期:1996-07-01 00:00:00
abstract::Unilateral intrahippocampal injection of tetanus toxin results in a chronic syndrome of intermittent epileptic seizures. During some of these seizures, rats develop a stereotypic, pathological motor behavior that indicates secondary generalization of epileptic activity. We report that secondary generalization was prec...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.4.2217
更新日期:2000-04-01 00:00:00
abstract::In free viewing, the eyes return to previously visited locations rather frequently, even though the attentional and memory-related processes controlling eye-movement show a strong antirefixation bias. To overcome this bias, a special refixation triggering mechanism may have to be recruited. We probed the neural eviden...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00121.2018
更新日期:2018-11-01 00:00:00
abstract::1. The effects of inhibitory postsynaptic potential (IPSP) barrages on coding of sinusoidal length inputs were investigated in slowly and rapidly adapting stretch receptors of crayfish (RM1 and RM2, respectively). To examine the contribution of postsynaptic firings, a description was obtained of the temporal correlati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.63.6.1520
更新日期:1990-06-01 00:00:00
abstract::Understanding how the brain processes sensory input to generate behavior remains an important problem in neuroscience. Towards this end, it is useful to compare results obtained across multiple species to gain understanding as to the general principles of neural coding. Here we investigated hindbrain pyramidal cell ac...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00594.2016
更新日期:2016-12-01 00:00:00
abstract::Spatiotemporal convergence and two-dimensional (2-D) neural tuning have been proposed as a major neural mechanism in the signal processing of linear acceleration. To examine this hypothesis, we studied the firing properties of primary otolith afferents and central otolith neurons that respond exclusively to horizontal...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.4.2113
更新日期:2000-10-01 00:00:00
abstract::Movement duration is an integral component of motor control, but nearly all extant optimization models of motor planning prefix duration instead of explaining it. Here we propose a new optimization principle that predicts movement duration. The model assumes that the brain attempts to minimize movement duration under ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00751.2005
更新日期:2006-06-01 00:00:00
abstract::Extracellular recordings of 209 neurons were obtained with carbon fiber-containing multibarrel micropipettes. The cells were isolated in the primary somatosensory cortex of cats anesthetized with barbiturate and classified according to the nature of their response to natural stimuli, the nature of the surrounding mult...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.52.6.1066
更新日期:1984-12-01 00:00:00
abstract::The noted disruption of thalamocortical connections and abnormalities in tactile sensory function has resulted in a new definition of cerebral palsy (CP) that recognizes the sensorimotor integration process as central to the motor impairments seen in these children. Despite this updated definition, the connection betw...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00602.2014
更新日期:2015-05-01 00:00:00
abstract::1. Evoked potentials restricted to the magnocellular portion of the mediodorsal nucleus (MDmc) of the thalamus were recorded after stimulation of the olfactory bulb (OB) and the posterior orbital cortex of the frontal lobe (OFC). Potentials evoked by stimulation of OB were probably trans-synaptically elicited, while p...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1980.43.1.69
更新日期:1980-01-01 00:00:00