Drug use in renal failure.

Abstract:

:The spectrum of interaction between drugs and the kidney is broad. Most drugs are excreted at least partially by the kidney, and renal function affects drug bioavailability, volume of drug distribution, and drug metabolism and rate of drug elimination. Drug therapy not only is potentially hazardous in patients with renal failure but also can cause a number of renal diseases. The clinician should be familiar with the pharmacologic and potential toxic effects of any drug used in a patient with uremia and should monitor creatinine clearance or at least serum creatinine level as a gauge of renal function. The drug regimen can be modified according to these measurements, either by administering a constant dose and varying the interval or by varying the dose and keeping the interval constant.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Henrich WL,Anderson RJ

doi

10.1080/00325481.1978.11714978

subject

Has Abstract

pub_date

1978-11-01 00:00:00

pages

153-63

issue

5

eissn

0032-5481

issn

1941-9260

journal_volume

64

pub_type

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