Nonalcoholic fatty liver disease: hepatic manifestation of obesity and the metabolic syndrome.

Abstract:

:Obesity is currently a worldwide epidemic, and will likely only increase in prevalence in the coming years. The incidence of the metabolic syndrome (MetS) seems to be paralleling obesity. The MetS is strongly linked to insulin resistance, abdominal obesity, diabetes mellitus, and dyslipidemia. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and the MetS. Although not currently a formal component of the MetS, data suggest a very strong correlation between NAFLD and the MetS; insulin resistance appears to be the common factor. Nonalcoholic steatohepatitis (NASH) is a more advanced stage in the spectrum of NAFLD, which can progress to cirrhosis. Management strategies for NAFLD are conceivably similar to those for the MetS, which focus on lifestyle measures aimed at weight reduction and maintenance. The purpose of this review is to highlight the growing epidemic of obesity and the MetS, and the strong likelihood of an increase in the prevalence of the already widely existent combination of NAFLD/NASH. This article describes pharmacological treatments including novel therapies aimed at the hepatic pathophysiologic process, as well as surgical options. The increasing prevalence of obesity and the MetS places a large population at risk for developing hepatic failure. Therefore, NAFLD must be acknowledged as a major worldwide public health concern.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Boppidi H,Daram SR

doi

10.3810/pgm.2008.07.1800

subject

Has Abstract

pub_date

2008-07-31 00:00:00

pages

E01-7

issue

2

eissn

0032-5481

issn

1941-9260

journal_volume

120

pub_type

杂志文章,评审
  • Clinical effects of colesevelam in Hispanic subjects with primary hyperlipidemia and prediabetes.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of colesevelam in Hispanic subjects with primary hyperlipidemia and prediabetes. MATERIALS AND METHODS:A 16-week, randomized, double-blind, placebo-controlled, multinational study evaluating colesevelam in participants with primary hyperlipidemia (low-density lipoprotein c...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.3810/pgm.2012.07.2564

    authors: Rosenstock J,Hernandez-Triana E,Handelsman Y,Misir S,Jones MR

    更新日期:2012-07-01 00:00:00

  • Fever following abdominal surgery. Unusual infectious causes.

    abstract::Identification of the cause and subsequent specific therapy are indicated for those prolonged or relapsing fevers that follow abdominal surgery. On rare occasions, these fevers can be attributed to potentially life-threatening occult infections, including maxillary sinusitis, acute cholecystitis, antibiotic-related ps...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1986.11699288

    authors: Gleckman RA,Roth RM

    更新日期:1986-02-01 00:00:00

  • The new hepatitis B vaccine. How, when, and why to use it.

    abstract::A hepatitis B vaccine derived from the plasma of carriers of hepatitis B virus has recently become generally available in the United States. Its use is recommended in groups considered to be at high risk of hepatitis B because of their exposure to potentially infectious blood, saliva, or semen. Experience in more than...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1983.11697828

    authors: Kutcher WL

    更新日期:1983-05-01 00:00:00

  • Diagnosis and management of nasal congestion: the role of intranasal corticosteroids.

    abstract::Nasal congestion is considered the most bothersome of allergic rhinitis (AR) symptoms and can significantly impair ability to function at work, home, and school. Effective management of AR-related nasal congestion depends on accurate diagnosis and appropriate treatment. Many individuals with AR and AR-related congesti...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2009.01.1961

    authors: Benninger M

    更新日期:2009-01-01 00:00:00

  • Surgical treatment of reflux esophagitis and stricture.

    abstract::Surgical intervention is usually indicated in reflux esophagitis when medical therapy fails to control symptoms. Since most patients with peptic esophagitis also have a sliding hiatal hernia, early procedures focused on hernia repair. Weakness of the lower esophageal sphincter is now known to be the pathogenetic mecha...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11712121

    authors: Woodward ER

    更新日期:1977-02-01 00:00:00

  • Dyspareunia of vulvo-vaginal origin. Causes and management.

    abstract::Difficult or painful coitus is a symptom, not a pathologic entity. It may be caused by a congenital anomaly, an organic lesion, or a functional disorder of the vulva or vagina, or it may be psychic in origin. Although its cause can usually be determined relatively easily, a conditioned reflex created by a preexisting ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1983.11697774

    authors: Huffman JW

    更新日期:1983-02-01 00:00:00

  • Asthma management. The case for aiming at control rather than merely relief.

    abstract::Asthma is a common and eminently treatable disease. Most asthma patients are initially seen by primary care physicians, who are likely to have a significant part in management. Research has provided physicians with a better understanding of the pathophysiologic basis of asthma and new antiasthma agents. Guidelines hav...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.03.416

    authors: Keenan JM

    更新日期:1998-03-01 00:00:00

  • Adolescent sexual intercourse. Strategies for promoting abstinence in teens.

    abstract::As sex, drugs, and rock 'n' roll have given way to STDs, HIV, and AIDS, adolescent sex has become an increasingly high-risk behavior. Dr Kay strongly believes that primary care physicians can have a prominent role in educating teens and their parents about the consequences of premature sexual activity and in promoting...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Kay LE

    更新日期:1995-06-01 00:00:00

  • Effect of renal impairment on the pharmacokinetics, efficacy, and safety of albiglutide.

    abstract:BACKGROUND:Chronic kidney disease is frequently present in patients with type 2 diabetes mellitus (T2DM). New therapeutic options in this patient subpopulation are needed. OBJECTIVES:Assess the effect of renal impairment on the pharmacokinetics (PK), efficacy, and safety of albiglutide in single- and multiple-dose stu...

    journal_title:Postgraduate medicine

    pub_type: 临床试验,杂志文章

    doi:10.3810/pgm.2014.05.2754

    authors: Young MA,Wald JA,Matthews JE,Yang F,Reinhardt RR

    更新日期:2014-05-01 00:00:00

  • Primary Pseudomonas maltophilia infection of the lung.

    abstract::To our knowledge, this is the first reported case of primary Pseudomonas maltophilia pneumonia. Presenting symptoms were fever and chills of two days' duration and a density in the right upper lobe. Sputum culture showed normal flora, and multiple blood cultures were negative. Antibiotic therapy initially with penicil...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715067

    authors: Sarkar TK,Gilardi G,Aguam AS,Josephson J,Leventhal GL

    更新日期:1979-02-01 00:00:00

  • Alpha 1-blocker combination therapy for hypertension.

    abstract::Combination therapy is a cost-effective and rational approach to treatment of severe hypertension and of mild to moderate hypertension that is refractory to monotherapy. The method has several advantages, most notably improved tolerability and enhanced antihypertensive efficacy. Long-term prospective studies are neede...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1998.09.581

    authors: Houston MC

    更新日期:1998-09-01 00:00:00

  • Varicose veins. Their symptoms, complications, and management.

    abstract::Varicose veins are a common problem that still presents a major challenge to the physician and the patient. Complete surgical removal of the malfunctioning veins has proved to be the most effective management for significant varicosities, although several nonsurgical methods are available for mild cases or those not s...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1979.11715178

    authors: Lofgren KA

    更新日期:1979-06-01 00:00:00

  • Carotid endarterectomy. Which patients can benefit?

    abstract::Carotid endarterectomy for carotid artery stenosis is valuable for some patients, but not all. Results of clinical trials in symptomatic and asymptomatic patients provide guidance on use of this common vascular procedure. The authors of this article describe the controversies and concerns with the procedure and give t...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2000.5.15.1093

    authors: Ingall TJ,Dodick DW,Zimmerman RS

    更新日期:2000-05-15 00:00:00

  • Pediatric poisoning the first 30 minutes.

    abstract::Two distinct subpopulations in the pediatric age-group are particularly at risk for poisoning, and the substances likely to be ingested by each group differ. The method of critical care given here incorporates consideration of specific types of poisoning into an overall plan of general diagnostic and therapeutic measu...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716152

    authors: Driggers DA

    更新日期:1982-08-01 00:00:00

  • Chronic stable angina pectoris.

    abstract::Preview In most patients with stable angina pectoris, symptoms can be controlled successfully with drug therapy. Revascularization procedures should be reserved for those at high risk for cardiac events and those who do not respond to optimal therapy with any of the three classes of antianginal agents. In this article...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1995.11946093

    authors: Thadani U,Chohan A

    更新日期:1995-12-01 00:00:00

  • Liver transplantation. New hope for many patients.

    abstract::Because of the broad range of physiologic problems and the many potential sources of complications, liver transplantation patients require contributions from virtually the complete spectrum of medical science. The evolving specialty of liver transplantation has eagerly assimilated advances in surgical techniques, anes...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1990.11704566

    authors: Williams JW,Sabesin SM

    更新日期:1990-02-01 00:00:00

  • Middle ear symptoms while flying.

    abstract::Preview Few people can say they have never experienced some form of pressure-related changes while flying. Although uncommon on commercial flights, severe middle ear blocks do occur. Drawing from his experience treating military pilots, Dr Brown discusses the causes of barotrauma, steps that airline passengers can tak...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1994.11945888

    authors: Brown TP

    更新日期:1994-08-01 00:00:00

  • Persistent hoarseness: an aggressive approach for early detection of laryngeal cancer.

    abstract::Persistent hoarseness in a patient should always alert the physician to the possibility of laryngeal carcinoma. Prompt visualization of the larynx is essential, particularly in high-risk patients over 40 years of age without a history of upper respiratory infection. Mirror examination (indirect laryngoscopy) is the us...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1980.11715452

    authors: Johnson JT,Newman RK,Olson JE

    更新日期:1980-05-01 00:00:00

  • Follow-up after therapy for prostate cancer. Treating the problems and caring for the man.

    abstract::With prostate cancer being diagnosed and treated in more than 300,000 men each year, the pool of long-term survivors is dramatically increasing. Because these patients are usually elderly, they are often receiving follow-up care for unrelated problems in a primary care setting. This offers the physician an excellent o...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.1996.09.73

    authors: Freedman A,Hahn G,Love N

    更新日期:1996-09-01 00:00:00

  • Gastroesophageal reflux and asthma.

    abstract::Gastroesophageal reflux provokes asthma in many patients. Conversely, asthma predisposes to gastroesophageal reflux. In many patients, reflux therapy will ameliorate asthma. Recognition of this relationship is facilitated by physician awareness, clinical history, selected laboratory tests, and ultimately, a careful mo...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1989.11704343

    authors: Mansfield LE

    更新日期:1989-07-01 00:00:00

  • Carcinoid tumor of the thymus.

    abstract::Primary carcinoid tumor of the thymus is a rare, slow-growing neoplasm occurring most commonly in middle-aged men. The usual clinical manifestations are those of a mediastinal mass, although in asymptomatic patients, the diagnosis may be suggested by a routine chest roentgenogram. Excision is the most common treatment...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1984.11698575

    authors: Kogan J

    更新日期:1984-01-01 00:00:00

  • SARS-CoV-2 in pleural fluid in a kidney transplant patient.

    abstract::Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread all over the globe from China. Pleural involvement is not common; around 5-10% of patients can develop pleural effusion and little is known about the involvement of pleural str...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2020.1838817

    authors: Bennett D,Franchi F,De Vita E,Mazzei MA,Volterrani L,Disanto MG,Garosi G,Guarnieri A,Cusi MG,Bargagli E,Scolletta S,Valente S,Gusinu R,Frediani B

    更新日期:2020-10-27 00:00:00

  • How to avert impending stroke.

    abstract::Patients "lucky" enough to have a nondisabling transient ischemic attack as a warning sign of impending stroke deserve the best possible prophylactic treatment in an attempt to avert that catastrophe. Dr Edmeads provides a step-by-step discussion of diagnostic studies and therapeutic regimens that help avoid stroke in...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.1080/00325481.1992.11701427

    authors: Edmeads J

    更新日期:1992-08-01 00:00:00

  • Thyroid nodules--benign or malignant? 1. Diagnosis.

    abstract::Radioisotope scanning is an invaluable aid in determining whether a palpable thyroid nodule is benign or malignant. In many cases, however, precise diagnosis is impossible without needle biopsy or surgical exploration. ...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1977.11714543

    authors: Yao Y

    更新日期:1977-04-01 00:00:00

  • Physiologic evaluation of bronchial asthma.

    abstract::Preview No physician would treat hypertension without monitoring blood pressure, but some treat bronchial asthma without objectively measuring pulmonary function. This empirical approach is inappropriate, according to the authors, who discuss key measurements that should be taken to assess disease status, guide therap...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1995.11946003

    authors: Weiss SM,Petty TL

    更新日期:1995-06-01 00:00:00

  • One-stage posterior approach for treating multilevel noncontiguous thoracic and lumbar spinal tuberculosis.

    abstract:OBJECTIVES:Multilevel noncontiguous thoracic and lumbar spinal tuberculosis (MNST) is a relatively rare entity. The objective of this retrospective study was to investigate whether a technique involving a one-stage posterior debridement and decompression, combined with an intervertebral fusion and posterior instrumenta...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.2019.1552824

    authors: Chen RS,Liao X,Xiong ML,Chen FR,Wang BW,Huang JM,Chen XL,Yin GH,Liu HY,Jin DD

    更新日期:2019-01-01 00:00:00

  • Health promotion for children. Key to a lifetime of health.

    abstract::Evidence indicates that preventive healthcare in childhood reduces healthcare costs and enhances health. Physicians can assume a leadership role in promoting children's health by incorporating health promotion measures into their everyday practice, serving as resource persons or leaders in community and school efforts...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1987.11699791

    authors: Fletcher DJ,Nelson JH,Nelson NE

    更新日期:1987-04-01 00:00:00

  • Advances in interventional radiology. The search for less invasive management sparks new approaches.

    abstract::Many new, minimally invasive interventional radiology procedures are now viable alternatives to traditional invasive therapy. The radiology procedures can often be performed in the outpatient setting, and although expensive technology may be required, the overall cost to the patient may be lower in the long run. Endov...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:10.3810/pgm.2001.06.958

    authors: Montgomery ML,Sullivan JP

    更新日期:2001-06-01 00:00:00

  • Refractory left ventricular failure: use of two-dimensional echocardiography in identification of thrombi.

    abstract::A 65-year-old woman was hospitalized several times after having an acute anteroseptal transmural infarction. Her course was complicated by recurrent ventricular tachycardia and severe left ventricular failure. Chest x-ray films showed pulmonary congestion and mild right pleural effusion. Two-dimensional echocardiograp...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章

    doi:10.1080/00325481.1982.11716219

    authors: Cheng TC

    更新日期:1982-10-01 00:00:00

  • Hearing loss. A plan for individualized management.

    abstract::Because some cases of hearing loss demand urgent attention, an approach to patients with hearing loss should be adopted in the primary care setting that allows for systematic institution of an individualized and appropriate treatment plan. Workup is enhanced by categorizing the hearing loss as acute or chronic and con...

    journal_title:Postgraduate medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Ruckenstein MJ

    更新日期:1995-10-01 00:00:00