Kinetic properties of NMDA receptors in embryonic Xenopus spinal neurons.

abstract：:Adult neuronal phenotype is maintained, at least in part, by the sensitivity of individual neurons to a specific selection of neurotrophic factors and the availability of such factors in the neurons' environment. Nerve growth factor (NGF) increases the functional expression of Na(+) channel currents (I(Na)) and both N...

journal_title：Journal of neurophysiology

authors： Ford CP,Wong KV,Lu VB,Posse de Chaves E,Smith PA

更新日期：2008-03-01 00:00:00

abstract：:1. Intracellular and extracellular recordings were obtained from ganglion cells in the rabbit retina. The effect of N-methyl-DL-aspartate (NMDLA) and N-methyl-D-aspartate (NMDA) antagonists were studied with the use of a perfusion method for drug application. 2. NMDLA excited all ganglion cell types and caused a chara...

journal_title：Journal of neurophysiology

authors： Massey SC,Miller RF

更新日期：1990-01-01 00:00:00

abstract：:Populations of output neurons in the mammalian olfactory bulb (OB) exhibit distinct, widespread spatial and temporal activation patterns when stimulated with odorants. However, questions remain as to how ensembles of mitral/tufted (M/T) neurons in the mammalian OB represent odorant information. In this report, the sin...

journal_title：Journal of neurophysiology

authors： Lehmkuhle MJ,Normann RA,Maynard EM

更新日期：2006-03-01 00:00:00

abstract：:Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key functional microcircuits within layer 2/3 of mouse primary...

journal_title：Journal of neurophysiology

authors： Avermann M,Tomm C,Mateo C,Gerstner W,Petersen CC

更新日期：2012-06-01 00:00:00

abstract：:Support-surface movements are commonly used to examine balance control. Subjects typically receive a series of identical or randomly interspersed multidirectional balance perturbations and the atypical "first trial reaction" (evoked by the first perturbation) is often excluded from further analysis. However, this proc...

journal_title：Journal of neurophysiology

authors： Oude Nijhuis LB,Allum JH,Borm GF,Honegger F,Overeem S,Bloem BR

更新日期：2009-06-01 00:00:00

abstract：:1. B31 and B32 are pattern-initiator neurons in the buccal ganglia of Aplysia. Along with the B61/B62 neurons, B31/B32 are also motor neurons that innervate the 12 buccal muscle via the I2 nerve. This research was aimed at determining the physiological functions of the B31/B32 and B61/B62 neurons, and of the I2 muscle...

journal_title：Journal of neurophysiology

authors： Hurwitz I,Neustadter D,Morton DW,Chiel HJ,Susswein AJ

更新日期：1996-04-01 00:00:00

abstract：:Cacna1a encodes the pore-forming α1A subunit of CaV2.1 voltage-dependent calcium channels, which regulate neuronal excitability and synaptic transmission. Purkinje cells in the cortex of cerebellum abundantly express these CaV2.1 channels. Here, we show that homozygous tottering (tg) mice, which carry a loss-of-functi...

journal_title：Journal of neurophysiology

authors： de Oude NL,Hoebeek FE,Ten Brinke MM,de Zeeuw CI,Boele HJ

更新日期：2020-12-16 00:00:00

abstract：:Retinotopy is a fundamental organizing principle of the visual cortex. Over the years, a variety of techniques have been used to examine it. None of these techniques, however, provides a way to rapidly characterize retinotopy, at the submillimeter range, in alert, behaving subjects. Voltage-sensitive dye imaging (VSDI...

journal_title：Journal of neurophysiology

authors： Yang Z,Heeger DJ,Seidemann E

更新日期：2007-08-01 00:00:00

abstract：:Single-unit recordings were made from layer II/III anterior piriform cortex (aPCX) neurons in adult Wistar rats to examine odor response patterns to unilaterally and bilaterally delivered stimuli. Isoamyl acetate odor stimulation was presented either unilaterally through tubes inserted into the external nares, or bila...

journal_title：Journal of neurophysiology

authors： Wilson DA

更新日期：1997-07-01 00:00:00

abstract：:Numerous developmental changes in the nervous system occur during the first several weeks of the rodent lifespan. Therefore, many characteristics of neuronal function described at the cellular level from in vitro slice experiments conducted during this early time period may not generalize to adult ages. We investigate...

journal_title：Journal of neurophysiology

authors： Paul K,Cox CL

更新日期：2013-03-01 00:00:00

abstract：:The core region of primate auditory cortex contains a primary and two primary-like fields (AI, primary auditory cortex; R, rostral field; RT, rostrotemporal field). Although it is reasonable to assume that multiple core fields provide an advantage for auditory processing over a single primary field, the differential r...

journal_title：Journal of neurophysiology

authors： Bendor D,Wang X

更新日期：2008-08-01 00:00:00

abstract：:Neurons in the medial superior olive (MSO) are tuned to the interaural time difference (ITD) of sound arriving at the two ears. MSO neurons evoke a strongest response at their best delay (BD), at which the internal delay between bilateral inputs to MSO matches the external ITD. We performed extracellular recordings in...

journal_title：Journal of neurophysiology

authors： Day ML,Semple MN

更新日期：2011-10-01 00:00:00

abstract：:Visual tracking of moving targets requires the combination of smooth pursuit eye movements with catch-up saccades. In primates, catch-up saccades usually take place only during pursuit initiation because pursuit gain is close to unity. This contrasts with the lower and more variable gain of smooth pursuit in cats, whe...

journal_title：Journal of neurophysiology

authors： de Brouwer S,Missal M,Lefèvre P

更新日期：2001-08-01 00:00:00

abstract：:This study of chronic incomplete spinal cord injury (SCI) subjects investigated patterns of central motor drive (i.e., central activation) of the plantar flexors using interpolated twitches, and modulation of soleus H-reflexes during lengthening, isometric, and shortening muscle actions. In a recent study of the knee ...

journal_title：Journal of neurophysiology

authors： Kim HE,Corcos DM,Hornby TG

更新日期：2015-07-01 00:00:00

abstract：:To characterize spike coding in spinal neurons during rhythmic locomotor activity, we recorded from individual cells in the lumbar spinal cord of neonatal rats by using the on-cell patch-clamp technique. Locomotor activity was induced by N-methyl-D aspartate (NMDA) and 5-hydroxytryptamine (5-HT) and monitored by ventr...

journal_title：Journal of neurophysiology

authors： Raastad M,Kiehn O

更新日期：2000-05-01 00:00:00

abstract：:During walking, maintenance and coordination of activity in leg motoneurons requires intersegmental signal transfer. In a semi-intact preparation of the stick insect, we studied membrane potential modulations in mesothoracic (middle leg) motoneurons and local premotor nonspiking interneurons that were induced by stepp...

journal_title：Journal of neurophysiology

authors： Ludwar BCh,Westmark S,Büschges A,Schmidt J

更新日期：2005-10-01 00:00:00

abstract：:Previous studies have described maturational changes in GABAergic inhibitory synaptic transmission in the rodent somatosensory cortex during the early postnatal period. To determine whether alterations in the functional properties of synaptically localized GABA(A) receptors (GABA(A)Rs) contribute to development of inh...

journal_title：Journal of neurophysiology

authors： Dunning DD,Hoover CL,Soltesz I,Smith MA,O'Dowd DK

更新日期：1999-12-01 00:00:00

abstract：:Visual response properties of neurons in the dorsolateral geniculate nucleus (dLGN) have been well described in several species, but not in rats. Analysis of responses from the unanesthetized rat dLGN will be needed to develop quantitative models that account for visual behavior of rats. We recorded visual responses f...

journal_title：Journal of neurophysiology

authors： Sriram B,Meier PM,Reinagel P

更新日期：2016-06-01 00:00:00

abstract：:Expression of the 5-HT(1Apl(a)) receptor in Aplysia pleural sensory neurons inhibited 5-HT-mediated translocation of the novel PKC Apl II in sensory neurons and prevented PKC-dependent synaptic facilitation at sensory to motoneuron synapses (Nagakura et al. 2010). We now demonstrate that the ability of inhibitory rece...

journal_title：Journal of neurophysiology

authors： Dunn TW,Farah CA,Sossin WS

更新日期：2012-01-01 00:00:00

abstract：:The strength-duration relationship for extracellular stimulation is often assumed to be similar to the classical intracellular stimulation model, with a slope asymptotically approaching 1/τ at pulse durations shorter than chronaxy. We modeled extracellular neural stimulation numerically and analytically for several ce...

journal_title：Journal of neurophysiology

authors： Boinagrov D,Loudin J,Palanker D

更新日期：2010-10-01 00:00:00

abstract：:The primate posterior thalamus has been proposed to contribute to pain sensation, but its precise role is unclear. This is in part because spinothalamic tract (STT) neurons that project to the posterior thalamus have received little attention. In this study, antidromic mapping was used to identify individual STT neuro...

journal_title：Journal of neurophysiology

authors： Davidson S,Zhang X,Khasabov SG,Simone DA,Giesler GJ Jr

更新日期：2008-10-01 00:00:00

abstract：:We evaluated the role of the sodium/glutamate transporter at the synaptic terminals of cone photoreceptors in controlling postsynaptic response kinetics. The strategy was to measure the changes in horizontal cell response rate induced by blocking transporter uptake in cones with dihydrokainate (DHK). DHK was chosen as...

journal_title：Journal of neurophysiology

authors： Gaal L,Roska B,Picaud SA,Wu SM,Marc R,Werblin FS

更新日期：1998-01-01 00:00:00

abstract：:Similar motor regions are activated during voluntarily executed or observed movements. We investigated whether observing movements of one's own hand through a mirror will generate activations in the cortical motor regions of both the moving and nonmoving hands. Using the lateralized readiness potential (LRP), an elect...

journal_title：Journal of neurophysiology

authors： Touzalin-Chretien P,Dufour A

更新日期：2008-07-01 00:00:00

abstract：:Field potential recording was used to investigate properties of synaptic transmission and long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in both hippocampal slices of mutant mice in which the alpha-subunit of the olfactory cyclic nucleotide-gated channel (alpha3/OCNC)1 was rendered null and also in s...

journal_title：Journal of neurophysiology

authors： Parent A,Schrader K,Munger SD,Reed RR,Linden DJ,Ronnett GV

更新日期：1998-06-01 00:00:00

abstract：:The granular layer of the cerebellum has a disproportionately large number of excitatory (granule cells) versus inhibitory neurons (Golgi cells). Its synaptic organization is also unique with a dense reciprocal innervation between granule and Golgi cells but without synaptic contacts among the neurons of either popula...

journal_title：Journal of neurophysiology

authors： Maex R,De Schutter E

更新日期：1998-11-01 00:00:00

abstract：:Despite the importance of the thumb to hand function, little is known about the origins of thumb impairment poststroke. Accordingly, the primary purpose of this study was to assess whether thumb flexors have heightened stretch reflexes (SRs) following stroke-induced hand impairment. The secondary purpose was to compar...

journal_title：Journal of neurophysiology

authors： Towles JD,Kamper DG,Rymer WZ

更新日期：2010-10-01 00:00:00

abstract：:1. The stiffness during the initial portion of a ramp stretch was measured in cat peroneus longus muscle at rest and during maximal tetanic contractions produced by increasing numbers of motor units of the same type [slow (S), fast fatigue resistant (FR), or fast fatigable (FF)]. 2. This initial ramp stiffness was def...

journal_title：Journal of neurophysiology

authors： Petit J,Filippi GM,Gioux M,Hunt CC,Laporte Y

更新日期：1990-12-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and is often refractory to antiepileptic medications. The medial entorhinal area (MEA) is affected in TLE but mechanisms underlying hyperexcitability of MEA neurons require further elucidation. Previous studies suggest that inputs from the pres...

journal_title：Journal of neurophysiology

authors： Abbasi S,Kumar SS

更新日期：2015-11-01 00:00:00

abstract：:Impulse from soleus muscle afferents were recorded in premammillary cats that were walking on a treadmill. In normal walking the effects of gamma-motoneurons on impulse rates of muscle spindle afferents are confounded by the effects of the large length changes that occur. To isolate the effects of gamma-motoneurons th...

journal_title：Journal of neurophysiology

authors： Taylor J,Stein RB,Murphy PR

更新日期：1985-02-01 00:00:00

abstract：:It has been shown that tetanic stimulation of area 2 of the somatosensory cortex produces long-term potentiation in neurons in area 4gamma, and this has been suggested as the basis of learning new motor skills. The purpose of this study was to further elucidate the characteristics of this projection by the use of evok...

journal_title：Journal of neurophysiology

authors： Caria MA,Kaneko T,Kimura A,Asanuma H

更新日期：1997-06-01 00:00:00