Abstract：
:It has been shown that tetanic stimulation of area 2 of the somatosensory cortex produces long-term potentiation in neurons in area 4gamma, and this has been suggested as the basis of learning new motor skills. The purpose of this study was to further elucidate the characteristics of this projection by the use of evoked potentials in area 4gamma elicited by intracortical microstimulation of area 2. The experiments were carried out in cats and the following results were obtained. 1) In six animals, stimulation of a given site in area 2 elicited evoked potentials in a restricted region of area 4gamma, the size of which ranged from 1 to 1.5 mm2. These responses were labeled "localized responses." The evoked potentials were recorded from the superficial layers of the cortex, and were positive monophasic in shape. 2) In 16 animals, stimulation of a given site in area 2 elicited a focal response that was surrounded by smaller positive and monophasic potentials of <50% amplitude that spread broadly over area 4gamma. These responses were labeled "graded responses." 3) The sites that produced focal evoked potentials in area 4gamma extended along the direction of the radial fibers in area 2. These sites were defined as most effective segments (MESs). 4) The receptive fields of neurons along the MES in area 2 were similar to those of neurons recorded at the foci of the evoked potentials in area 4gamma. The results demonstrate that some of the projections from area 2 to area 4gamma are highly specific and that the somatosensory and motor areas that are connected by these specific projections receive functionally related peripheral input. These results are discussed in relation to possible mechanisms underlying motor learning.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Caria MA,Kaneko T,Kimura A,Asanuma Hdoi
10.1152/jn.1997.77.6.3107subject
Has Abstractpub_date
1997-06-01 00:00:00pages
3107-14issue
6eissn
0022-3077issn
1522-1598journal_volume
77pub_type
杂志文章abstract：:In the preceding report, we observed that tail-shock-induced sensitization of tail-elicited siphon withdrawal reflex (TSW) of Aplysia was expressed ipsilaterally but that dishabituation induced by an identical tail shock was expressed bilaterally. Here we examined the mechanisms of this differential lateralization. We...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00667.2003
更新日期：2004-02-01 00:00:00
abstract：:The acid-sensing ion channels (ASICs) form cation channels that are transiently activated by extracellular protons. They are expressed in dorsal root ganglia (DRG) neurons and in the periphery where they play a function in nociception and mechanosensation. Previous studies showed that FMRFamide and related peptides po...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00707.2002
更新日期：2003-05-01 00:00:00
abstract：:Targeting the melanin-concentrating hormone (MCH) system has been suggested as a potential treatment for obesity, anxiety disorders, as well as addiction. Despite the therapeutic potential of MCH agonists and antagonists, the endogenous factors regulating MCH activity, in particular those implicated in anxiety and rew...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00791.2010
更新日期：2011-03-01 00:00:00
abstract：:Morphine remains widely used in clinical settings due to its potent analgesic properties. However, one of the gravest risks of all opioids is their ability to induce respiratory depression and subsequent brain hypoxia that can lead to coma and death. Due to these life-threatening effects, our goal was to examine the e...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00445.2018
更新日期：2018-11-01 00:00:00
abstract：:The abilities of humans to discriminate the softness of rubber objects of differing compliance with a hand-held tool (a stylus) was measured under experimental conditions that differed as to how the tool was used and the kind of sensory information available. When the subject actively tapped or pressed the compliant o...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.83.4.1777
更新日期：2000-04-01 00:00:00
abstract：:The relationship among neonatal seizures, abnormalities of the electroencephalogram (EEG), brain injury, and long-term neurological outcome (e.g., epilepsy) remains controversial. The effects of hypoxia alone (Ha) and hypoxia-ischemia (HI) were studied in neonatal rats at postnatal day 7; both models generate EEG seiz...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00796.2014
更新日期：2015-11-01 00:00:00
abstract：:Gramicidin-perforated patch-clamp recordings were made from slices of the suprachiasmatic nucleus (SCN) of adult rats to characterize the role of gamma-amino butyric acid (GABA) in the circadian timing system. During the day, activation of GABA(A) receptors hyperpolarized the membrane of SCN neurons. During the night,...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00241.2001
更新日期：2002-02-01 00:00:00
abstract：:In this report we describe extracellular recordings made from ON and ON-OFF directionally selective (DS) ganglion cells in the rabbit retina during perfusion with agonists and antagonists to acetylcholine (ACh), glutamate, and gamma-aminobutyric acid (GABA). Nicotinic ACh agonists strongly excited DS ganglion cell in ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.77.2.675
更新日期：1997-02-01 00:00:00
abstract：:Hilar mossy cells represent a unique population of local circuit neurons in the hippocampus and dentate gyrus. Here we use electrophysiological techniques in acute preparations of hippocampal slices to demonstrate that depolarization of a single hilar mossy cell can produce robust inhibition of local GABAergic afferen...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00310.2006
更新日期：2006-11-01 00:00:00
abstract：:Sleep disturbances are prevalent in clinical anxiety, but it remains unclear whether they are cause and/or consequence of this condition. Fear conditioning constitutes a valid laboratory model for the acquisition of normal and pathological anxiety. To explore the relationship between disturbed sleep and anxiety in mor...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00657.2013
更新日期：2014-09-15 00:00:00
abstract：:The supratrigeminal region (SupV) receives abundant orofacial sensory inputs and descending inputs from the cortical masticatory area and contains premotor neurons that target the trigeminal motor nucleus (MoV). Thus it is possible that the SupV is involved in controlling jaw muscle activity via sensory inputs during ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01145.2007
更新日期：2008-10-01 00:00:00
abstract：:Rhythmic movements of the gastric mill and pyloric regions of the crustacean foregut are controlled by two stomatogastric neuronal networks that have been intensively studied in vitro. By using electromyographic recordings from the European lobster, Homarus gammarus, we have monitored simultaneously the motor activity...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.79.3.1396
更新日期：1998-03-01 00:00:00
abstract：:Basal ganglia circuits are organized as parallel loops that have been proposed to compete in a winner-take-all fashion to determine the appropriate behavioral outcome. However, limited experimental support for strong lateral inhibition mechanisms within striatal regions questions this model. Here, stimulation of the p...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.91002.2008
更新日期：2009-04-01 00:00:00
abstract：:We investigated adaptation to simple force field scaling to determine whether the same strategy is used as during adaptation to more complex changes in the mechanical environment. Subjects initially trained in a force field, consisting of a rightward lateral force with a parabolic spatial profile (PF). The field stren...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00269.2007
更新日期：2007-11-01 00:00:00
abstract：:1. The caudal photoreceptor (CPR) interneurons in the sixth abdominal ganglion of the crayfish are complex, multi-modal interneurons. These cells respond directly to light with tonic spike discharges, and they integrate synaptic input from an array of fili-form mechanoreceptors on the tailfan. They also provide input ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.5.3002
更新日期：1996-11-01 00:00:00
abstract：:A stratified organization of visual, somatic and acoustic representations was observed in the cat SC. Cells of the superficial laminae were exclusively visual. Visual, somatic, and acoustic cells were observed in the intermediate laminae while the deeper laminae were predominantly nonvisual. A detailed examination of ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1976.39.2.401
更新日期：1976-03-01 00:00:00
abstract：:1. The initial objective of this study was to determine whether respiratory-related neural assemblies exist in the brain stem midline. A second goal was to seek evidence for concurrent relationships among the neurons that could generate the detected synchrony. 2. Experiments were conducted on anesthetized, paralyzed, ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1992.67.4.905
更新日期：1992-04-01 00:00:00
abstract：:Mechanisms that could mitigate the effects of hypoxia on neuronal signaling are incompletely understood. We show that axonal performance of a locust visual interneuron varied depending on oxygen availability. To induce hypoxia, tracheae supplying the thoracic nervous system were surgically lesioned and action potentia...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00354.2016
更新日期：2016-09-01 00:00:00
abstract：:Recent experimental findings suggest that there may be rich physiological information embedded within the power spectrum of neurophysiological recordings, which, in addition to power in specific oscillatory frequencies, can be extracted with the appropriate model. This article reviews previous empirical and modeling r...
journal_title：Journal of neurophysiology
pub_type： 杂志文章,评审
doi：10.1152/jn.00722.2015
更新日期：2016-02-01 00:00:00
abstract：:The use of chronic intracortical multielectrode arrays has become increasingly prevalent in neurophysiological experiments. However, it is not obvious whether neuronal signals obtained over multiple recording sessions come from the same or different neurons. Here, we develop a criterion to assess single-unit stability...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.90920.2008
更新日期：2009-08-01 00:00:00
abstract：:Since sensory systems operate with a finite quantity of processing resources, an animal would benefit from prioritizing processing of sensory stimuli within a time window that is expected to provide key information. This behavioral manifestation of such prioritization is known as attention. Here, we investigate attent...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00604.2018
更新日期：2019-03-01 00:00:00
abstract：:There are many theories on the purpose of neural adaptation, but evidence remains elusive. Here, we discuss the recent work by Benucci et al. (Nat Neurosci 16: 724-729, 2013), who measured for the first time the immediate effects of adaptation on the overall activity of a neuronal population. These measurements confir...
journal_title：Journal of neurophysiology
pub_type： 评论,杂志文章
doi：10.1152/jn.00521.2013
更新日期：2014-08-01 00:00:00
abstract：:1. We examined excitation and the facilitatory effect on the heat responses induced by histamine in visceral polymodal receptors with the use of the canine testis-spermatic nerve preparation in vitro. 2. The proportion of units that showed excitation (> 10 impulses 1 min after application of histamine was initiated) i...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.3.1396
更新日期：1996-09-01 00:00:00
abstract：:The cerebellum of the mormyrid fish consists of three major divisions: the valvula, the central lobes, and the caudal lobes. Several studies have focused on the central lobes and the valvula, but little is known about the caudal lobes. The mormyrid caudal lobe includes anterior and posterior components. The anterior c...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00502.2007
更新日期：2007-09-01 00:00:00
abstract：:1. Single-unit electrical activity has been recorded from 34 dorsal horn neurons in the sacral segments (S1-2) of the spinal cord in halothane-anesthetized rats. All of the neurons had cutaneous receptive fields (RFs) on the rat's tail. The neurons were classified according to their responses to both innocuous and nox...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1990.63.5.1022
更新日期：1990-05-01 00:00:00
abstract：:We used multiunit recording to assess the effect of rotating one eye approximately 90 degrees at about the time of normal eye opening. Rotation of the eye did not alter the topography of the retinal maps onto visual cortex or superior colliculus. The intorted eye drove cells at most recording points in the contralater...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1983.50.3.618
更新日期：1983-09-01 00:00:00
abstract：:Hippocampal interneurons are excited via serotonin-gated ion channels. J. Neurophysiol. 78: 2493-2502, 1997. Serotonergic neurons of the median raphe nucleus heavily innervate hippocampal GABAergic interneurons located in stratum radiatum of area CA1, suggesting that this strong subcortical projection may modulate int...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.78.5.2493
更新日期：1997-11-01 00:00:00
abstract：:The interstitial nucleus of Cajal (INC) is thought to control torsional and vertical head posture. Unilateral microstimulation of the INC evokes torsional head rotation to positions that are maintained until stimulation offset. Unilateral INC inactivation evokes head position-holding deficits with the head tilted in t...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.90363.2008
更新日期：2008-09-01 00:00:00
abstract：:After a cortical lesion, cortical areas distant from the site of injury are known to undergo physiological and anatomical changes. However, the mechanisms through which reorganization of distant cortical areas is initiated are poorly understood. In a previous publication, we showed that the ventral premotor cortex (PM...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00792.2006
更新日期：2006-12-01 00:00:00
abstract：:1. The effects of inhibitory postsynaptic potential (IPSP) barrages on coding of sinusoidal length inputs were investigated in slowly and rapidly adapting stretch receptors of crayfish (RM1 and RM2, respectively). To examine the contribution of postsynaptic firings, a description was obtained of the temporal correlati...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1990.63.6.1520
更新日期：1990-06-01 00:00:00
