Abstract:
:In the last few years there has been a veritable explosion of knowledge about cyclic nucleotide phosphodiesterases. In particular, the accumulating data showing that there are a large number of different phosphodiesterase isozymes have triggered an equally large increase in interest about these enzymes. At least seven different gene families of cyclic nucleotide phosphodiesterase are currently known to exist in mammalian tissues. Most families contain several distinct genes, and many of these genes are expressed in different tissues as functionally unique alternative splice variants. This article reviews many of the more important aspects about the structure, cellular localization, and regulation of each family of phosphodiesterases. Particular emphasis is placed on new information obtained in the last few years about how differential expression and regulation of individual phosphodiesterase isozymes relate to their function(s) in the body. A substantial discussion of the currently accepted nomenclature is also included. Finally, a brief discussion is included about how the differences among distinct phosphodiesterase isozymes are beginning to be used as the basis for developing therapeutic agents.
journal_name
Physiol Revjournal_title
Physiological reviewsauthors
Beavo JAdoi
10.1152/physrev.1995.75.4.725subject
Has Abstractpub_date
1995-10-01 00:00:00pages
725-48issue
4eissn
0031-9333issn
1522-1210journal_volume
75pub_type
杂志文章,评审abstract::The urothelium, which lines the inner surface of the renal pelvis, the ureters, and the urinary bladder, not only forms a high-resistance barrier to ion, solute and water flux, and pathogens, but also functions as an integral part of a sensory web which receives, amplifies, and transmits information about its external...
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journal_title:Physiological reviews
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:Physiological reviews
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journal_title:Physiological reviews
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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