Vagal Afferent Innervation of the Airways in Health and Disease.

Abstract:

:Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collectively these nerves are essential for the regulation of respiratory physiology and pulmonary defense through local responses and centrally mediated neural pathways. Mechanical and chemical activation of airway afferents depends on a myriad of ionic and receptor-mediated signaling, much of which has yet to be fully explored. Alterations in the sensitivity and neurochemical phenotype of vagal afferent nerves and/or the neural pathways that they innervate occur in a wide variety of pulmonary diseases, and as such, understanding the mechanisms of vagal sensory function and dysfunction may reveal novel therapeutic targets. In this comprehensive review we discuss historical and state-of-the-art concepts in airway sensory neurobiology and explore mechanisms underlying how vagal sensory pathways become dysfunctional in pathological conditions.

journal_name

Physiol Rev

journal_title

Physiological reviews

authors

Mazzone SB,Undem BJ

doi

10.1152/physrev.00039.2015

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

975-1024

issue

3

eissn

0031-9333

issn

1522-1210

pii

96/3/975

journal_volume

96

pub_type

杂志文章,评审
  • Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation.

    abstract::The kidneys play a vital role in mineral homeostasis. In this review, the handling of calcium and the methods currently applied to measuring its intracellular concentration are discussed. The bulk of calcium absorption proceeds in proximal tubules, with smaller fractions recovered by thick ascending limbs, distal conv...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1995.75.3.429

    authors: Friedman PA,Gesek FA

    更新日期:1995-07-01 00:00:00

  • Peptide hormone regulation of angiogenesis.

    abstract::It is now apparent that regulation of blood vessel growth contributes to the classical actions of hormones on development, growth, and reproduction. Endothelial cells are ideally positioned to respond to hormones, which act in concert with locally produced chemical mediators to regulate their growth, motility, functio...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00024.2009

    authors: Clapp C,Thebault S,Jeziorski MC,Martínez De La Escalera G

    更新日期:2009-10-01 00:00:00

  • Coronary physiology.

    abstract::The major areas of normal coronary physiological research since Berne's 1964 review have been the measurement of ventricular transmural blood flow distribution with microspheres, the adenosine hypothesis of local metabolic control of coronary blood flow, and the autonomic control of coronary blood flow. There is an im...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1983.63.1.1

    authors: Feigl EO

    更新日期:1983-01-01 00:00:00

  • Replicative senescence of human fibroblast-like cells in culture.

    abstract::The life history of fibroblast and fibroblast-like cells includes an initial stage of outgrowth and establishment in culture; a period of vigorous proliferation which has a variable length, depending on the tissue of origin, age of the donor, etc.; a period of declining proliferative vigor which includes substantial c...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1993.73.3.617

    authors: Cristofalo VJ,Pignolo RJ

    更新日期:1993-07-01 00:00:00

  • Intercellular Ca(2+) waves: mechanisms and function.

    abstract::Intercellular calcium (Ca(2+)) waves (ICWs) represent the propagation of increases in intracellular Ca(2+) through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide diversity of cells and have been extensively studied in vitro. More recent stud...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00029.2011

    authors: Leybaert L,Sanderson MJ

    更新日期:2012-07-01 00:00:00

  • The organizing potential of sphingolipids in intracellular membrane transport.

    abstract::Eukaryotes are characterized by endomembranes that are connected by vesicular transport along secretory and endocytic pathways. The compositional differences between the various cellular membranes are maintained by sorting events, and it has long been believed that sorting is based solely on protein-protein interactio...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.2001.81.4.1689

    authors: Holthuis JC,Pomorski T,Raggers RJ,Sprong H,Van Meer G

    更新日期:2001-10-01 00:00:00

  • Nutrition and aging: changes in the regulation of energy metabolism with aging.

    abstract::Changes in energy regulation occur during normal aging and contribute to the common phenomenon of weight and fat losses late in life. This review synthesizes data on aging-related changes in energy intake and energy expenditure and on the regulation of energy intake and expenditure. The ability of older adults to accu...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00019.2005

    authors: Roberts SB,Rosenberg I

    更新日期:2006-04-01 00:00:00

  • Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.

    abstract::It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The m...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00018.2019

    authors: Riera-Domingo C,Audigé A,Granja S,Cheng WC,Ho PC,Baltazar F,Stockmann C,Mazzone M

    更新日期:2020-01-01 00:00:00

  • Properties and regulation of the minK potassium channel protein.

    abstract::The minK gene encodes a protein of 130 amino acids that has a single transmembrane segment and is expressed in many tissues including heart, uterus, and kidney. When Xenopus oocytes are injected with minK mRNA, a very slowly activating voltage-dependent potassium current is induced in these cells. The induced channels...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1997.77.3.627

    authors: Kaczmarek LK,Blumenthal EM

    更新日期:1997-07-01 00:00:00

  • Basic mechanisms of cardiac impulse propagation and associated arrhythmias.

    abstract::Propagation of excitation in the heart involves action potential (AP) generation by cardiac cells and its propagation in the multicellular tissue. AP conduction is the outcome of complex interactions between cellular electrical activity, electrical cell-to-cell communication, and the cardiac tissue structure. As shown...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00025.2003

    authors: Kléber AG,Rudy Y

    更新日期:2004-04-01 00:00:00

  • Dendritic cells: immune regulators in health and disease.

    abstract::Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although DCs are a moderately diverse set of cells, they all have potent antigen-prese...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00023.2001

    authors: Lipscomb MF,Masten BJ

    更新日期:2002-01-01 00:00:00

  • Oxygen sensing and molecular adaptation to hypoxia.

    abstract::This review focuses on the molecular stratagems utilized by bacteria, yeast, and mammals in their adaptation to hypoxia. Among this broad range of organisms, changes in oxygen tension appear to be sensed by heme proteins, with subsequent transfer of electrons along a signal transduction pathway which may depend on rea...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1996.76.3.839

    authors: Bunn HF,Poyton RO

    更新日期:1996-07-01 00:00:00

  • Neoteny, Prolongation of Youth: From Naked Mole Rats to "Naked Apes" (Humans).

    abstract::It has been suggested that highly social mammals, such as naked mole rats and humans, are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot operate as a mechanism facilitating natural selection because the pressure of this selection is strongly reduced due to 1) a specific social str...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00040.2015

    authors: Skulachev VP,Holtze S,Vyssokikh MY,Bakeeva LE,Skulachev MV,Markov AV,Hildebrandt TB,Sadovnichii VA

    更新日期:2017-04-01 00:00:00

  • Melanin pigmentation in mammalian skin and its hormonal regulation.

    abstract::Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents interacting via pathways activated by receptor-dependent and -independent mechanisms, in hormonal...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00044.2003

    authors: Slominski A,Tobin DJ,Shibahara S,Wortsman J

    更新日期:2004-10-01 00:00:00

  • Beyond neurons: evidence that immune and glial cells contribute to pathological pain states.

    abstract::Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such neuropathic pain conditions, sensory processing in the affected body region becomes grossly abnormal. Despite decades of research, currently available drugs largely fail to control such pain. This review explores the possibili...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00011.2002

    authors: Watkins LR,Maier SF

    更新日期:2002-10-01 00:00:00

  • Molecular physiology of vertebrate Na+/H+ exchangers.

    abstract::This review describes recent progress concerning the molecular aspects of the Na+/H+ exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume, and transepithelial Na+ transport. It exists in virtually all cells with cell type-dependent pattern of isoform expression, and it is regulat...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1997.77.1.51

    authors: Wakabayashi S,Shigekawa M,Pouyssegur J

    更新日期:1997-01-01 00:00:00

  • Cellular and molecular specificity of pituitary gland physiology.

    abstract::The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of multiple signaling transduction pathways and transcriptional regulatory networks that cooperate f...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00003.2011

    authors: Perez-Castro C,Renner U,Haedo MR,Stalla GK,Arzt E

    更新日期:2012-01-01 00:00:00

  • Signaling mechanisms regulating endothelial permeability.

    abstract::The microvascular endothelial cell monolayer localized at the critical interface between the blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying the essential nutrients needed for the survival of the organism. The endothelial cell is an exquisite "sensor" that responds to div...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00012.2005

    authors: Mehta D,Malik AB

    更新日期:2006-01-01 00:00:00

  • Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy.

    abstract::The distal tubule of the mammalian kidney, defined as the region between the macula densa and the collecting duct, is morphologically and functionally heterogeneous. This heterogeneity has stymied attempts to define functional properties of individual cell types and has led to controversy concerning mechanisms and reg...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.2000.80.1.277

    authors: Reilly RF,Ellison DH

    更新日期:2000-01-01 00:00:00

  • Nonvertebrate hemoglobins: functions and molecular adaptations.

    abstract::Hemoglobin (Hb) occurs in all the kingdoms of living organisms. Its distribution is episodic among the nonvertebrate groups in contrast to vertebrates. Nonvertebrate Hbs range from single-chain globins found in bacteria, algae, protozoa, and plants to large, multisubunit, multidomain Hbs found in nematodes, molluscs a...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.2001.81.2.569

    authors: Weber RE,Vinogradov SN

    更新日期:2001-04-01 00:00:00

  • Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear.

    abstract::The last 10 years have witnessed a surge of interest for the mechanisms underlying the acquisition and extinction of classically conditioned fear responses. In part, this results from the realization that abnormalities in fear learning mechanisms likely participate in the development and/or maintenance of human anxiet...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00037.2009

    authors: Pape HC,Pare D

    更新日期:2010-04-01 00:00:00

  • Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability.

    abstract::Animals synchronize to the environmental day-night cycle by means of an internal circadian clock in the brain. In mammals, this timekeeping mechanism is housed in the suprachiasmatic nucleus (SCN) of the hypothalamus and is entrained by light input from the retina. One output of the SCN is a neural code for circadian ...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00027.2019

    authors: Harvey JRM,Plante AE,Meredith AL

    更新日期:2020-10-01 00:00:00

  • Measurement of intracellular calcium.

    abstract::To a certain extent, all cellular, physiological, and pathological phenomena that occur in cells are accompanied by ionic changes. The development of techniques allowing the measurement of such ion activities has contributed substantially to our understanding of normal and abnormal cellular function. Digital video mic...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.1999.79.4.1089

    authors: Takahashi A,Camacho P,Lechleiter JD,Herman B

    更新日期:1999-10-01 00:00:00

  • Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering.

    abstract::Voltage-sensing phosphatase (VSP) contains a voltage sensor domain (VSD) similar to that in voltage-gated ion channels, and a phosphoinositide phosphatase region similar to phosphatase and tensin homolog deleted on chromosome 10 (PTEN). The VSP gene is conserved from unicellular organisms to higher vertebrates. Membra...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00056.2017

    authors: Okamura Y,Kawanabe A,Kawai T

    更新日期:2018-10-01 00:00:00

  • Myoediting: Toward Prevention of Muscular Dystrophy by Therapeutic Genome Editing.

    abstract::Muscular dystrophies represent a large group of genetic disorders that significantly impair quality of life and often progress to premature death. There is no effective treatment for these debilitating diseases. Most therapies, developed to date, focus on alleviating the symptoms or targeting the secondary effects, wh...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00046.2017

    authors: Zhang Y,Long C,Bassel-Duby R,Olson EN

    更新日期:2018-07-01 00:00:00

  • Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

    abstract::The neuromuscular junction is the chemical synapse between motor neurons and skeletal muscle fibers. It is designed to reliably convert the action potential from the presynaptic motor neuron into the contraction of the postsynaptic muscle fiber. Diseases that affect the neuromuscular junction may cause failure of this...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00033.2014

    authors: Tintignac LA,Brenner HR,Rüegg MA

    更新日期:2015-07-01 00:00:00

  • Honeybees as a model for the study of visually guided flight, navigation, and biologically inspired robotics.

    abstract::Research over the past century has revealed the impressive capacities of the honeybee, Apis mellifera, in relation to visual perception, flight guidance, navigation, and learning and memory. These observations, coupled with the relative ease with which these creatures can be trained, and the relative simplicity of the...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00005.2010

    authors: Srinivasan MV

    更新日期:2011-04-01 00:00:00

  • Ca2+-activated K+ channels: from protein complexes to function.

    abstract::Molecular research on ion channels has demonstrated that many of these integral membrane proteins associate with partner proteins, often versatile in their function, or even assemble into stable macromolecular complexes that ensure specificity and proper rate of the channel-mediated signal transduction. Calcium-activa...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00049.2009

    authors: Berkefeld H,Fakler B,Schulte U

    更新日期:2010-10-01 00:00:00

  • Molecular Determinants of BK Channel Functional Diversity and Functioning.

    abstract::Large-conductance Ca2+- and voltage-activated K+ (BK) channels play many physiological roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion. BK channels are tetramers in which the pore-forming α subunit is coded by a single gene (Slowpoke, KCNMA1). In this review, we first highlight t...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00001.2016

    authors: Latorre R,Castillo K,Carrasquel-Ursulaez W,Sepulveda RV,Gonzalez-Nilo F,Gonzalez C,Alvarez O

    更新日期:2017-01-01 00:00:00

  • Astrocyte reactivity and reactive astrogliosis: costs and benefits.

    abstract::Astrocytes are the most abundant cells in the central nervous system (CNS) that provide nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis maintaining functions. During the past two decades, astrocytes emerged also as increasingly important regulators of neuronal functions inclu...

    journal_title:Physiological reviews

    pub_type: 杂志文章,评审

    doi:10.1152/physrev.00041.2013

    authors: Pekny M,Pekna M

    更新日期:2014-10-01 00:00:00