Abstract:
:The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron. Hepcidin and ferroportin also play a role in host defense and inflammation, and hepcidin synthesis is induced by inflammatory signals including interleukin-6 and activin B. This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
journal_name
Physiol Revjournal_title
Physiological reviewsauthors
Ganz Tdoi
10.1152/physrev.00008.2013subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1721-41issue
4eissn
0031-9333issn
1522-1210pii
93/4/1721journal_volume
93pub_type
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journal_title:Physiological reviews
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journal_title:Physiological reviews
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更新日期:2002-10-01 00:00:00