Evaluation of dabigatran bleeding adverse reaction reports in the FDA adverse event reporting system during the first year of approval.

abstract：:Abstract Cetuximab and panitumumab, monoclonal antibodies used to target the epidermal growth factor receptor (EGFR), were recently approved by the United States Food and Drug Administration for use as single agents or in combination with other chemotherapy drugs in the treatment of metastatic colorectal cancer. The a...

journal_title：Pharmacotherapy

authors： Patel DK

更新日期：2008-11-01 00:00:00

abstract：:Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety ...

journal_title：Pharmacotherapy

authors： Farrokh S,Bon J,Erdman M,Tesoro E

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:It is known that γ-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study explores the methylation status of the GGH promoter in peripheral blood and its association with MT...

journal_title：Pharmacotherapy

authors： Wang SM,Kong XY,Li M,Sun LL,Yan D

更新日期：2020-07-01 00:00:00

abstract：:Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for ...

journal_title：Pharmacotherapy

authors： Roberts KD,Sulaiman RM,Rybak MJ

更新日期：2015-10-01 00:00:00

abstract：:To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...

journal_title：Pharmacotherapy

authors： Anastasio GD,Shaughnessy AF

更新日期：1997-05-01 00:00:00

abstract：:Methemoglobin, a form of hemoglobin that does not bind oxygen, is produced when iron in red blood cells is oxidized from the ferrous state to the ferric state. Methemoglobinemia develops in the presence of oxidizing agents, such as benzocaine-containing topical anesthetic sprays, and it is characterized by cyanosis. I...

journal_title：Pharmacotherapy

authors： Throm MJ,Stevens MD,Hansen C

更新日期：2007-08-01 00:00:00

abstract：STUDY OBJECTIVE:To determine clinical and microbiologic success in patients receiving adjunctive aerosolized antibiotics for the treatment of ventilator-associated pneumonia (VAP). DESIGN:Retrospective medical record review. SETTING:Level I trauma intensive care unit of a large academic medical center. PATIENTS:Fort...

journal_title：Pharmacotherapy

authors： Czosnowski QA,Wood GC,Magnotti LJ,Croce MA,Swanson JM,Boucher BA,Fabian TC

更新日期：2009-09-01 00:00:00

abstract：:The prevalence of diabetes mellitus has grown to staggering numbers, and its incidence is expected to rise in the next 2 decades. The need for novel approaches to treat hyperglycemia cannot be ignored. Current agents have been shown to modestly improve glycemia and in some cases prevent complications of diabetes, but ...

journal_title：Pharmacotherapy

authors： Shah NK,Deeb WE,Choksi R,Epstein BJ

更新日期：2012-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of standardized Ginkgo biloba leaf extracts (GBE) on outcome parameters of hemostasis associated with risk of bleeding. DESIGN:Meta-analysis of 18 randomized controlled trials. SUBJECTS:A total of 1985 adults were enrolled to receive either GBE or placebo; 87% were patients wit...

journal_title：Pharmacotherapy

authors： Kellermann AJ,Kloft C

更新日期：2011-05-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：:Warfarin and unfractionated heparin have been in clinical use for more than 50 years. Both are effective anticoagulants, but their use is associated with a number of impediments, including the need for intensive coagulation monitoring, wide variation in dose-response relationships, multiple drug interactions (in the c...

journal_title：Pharmacotherapy

authors： Hawkins D

更新日期：2004-07-01 00:00:00

abstract：:We retrospectively reviewed the charts of 120 patients who received an initial prescription of iron from a resident physician in internal medicine to determine how accurately house officers diagnose iron-deficiency anemia before initiating iron therapy. Each patient's laboratory records were reviewed for the 3-month p...

journal_title：Pharmacotherapy

authors： Abernathy KA,Meuleman JR

更新日期：1996-05-01 00:00:00

abstract：:The atypical antipsychotic agents clozapine and risperidone bring new insight into the care and treatment of patients with schizophrenia. Since their introduction, several names (e.g., novel, atypical, serotonergic-dopaminergic antagonist) have been used to describe the nature of these compounds. The agents are unique...

journal_title：Pharmacotherapy

authors： Raleigh F

更新日期：1996-11-01 00:00:00

abstract：:High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on ...

journal_title：Pharmacotherapy

authors： Brunner LJ,DiPiro JT,Feldman S

更新日期：1995-01-01 00:00:00

abstract：:The renal pharmacologic effects of intravenous dopamine in doses of 0.5-3.0 micrograms/kg/min include increases in renal blood flow, glomerular filtration rate, solute excretion, and urine flow. Clinical studies revealed that low-dose dopamine can reverse oliguria, but these studies were poorly controlled, were confou...

journal_title：Pharmacotherapy

authors： Dasta JF,Kirby MG

更新日期：1986-11-01 00:00:00

abstract：:Warfarin is considered a high-risk drug because of its narrow therapeutic window, variability in dose response, and multitude of drug and food interactions. Although travel advice is available for patients who are taking warfarin, it is geared toward patients who are traveling to developed countries and tends to be la...

journal_title：Pharmacotherapy

authors： Truong T,Armor BL

更新日期：2012-03-01 00:00:00

abstract：:Drug-induced neutropenia and agranulocytosis are rare adverse events but can be fatal. Neutropenia can be induced by a myriad of drugs from almost every pharmacologic class. Octreotide is a somatostatin analog that has been used to treat variceal bleeding, acromegaly, and severe diarrhea associated with metastatic tum...

journal_title：Pharmacotherapy

authors： Tse SS,Kish T

更新日期：2017-06-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the microbiologic and clinical outcomes of patients with extended-spectrum beta-lactamase (ESBL)-producing isolates over a 2-year period. DESIGN:Retrospective analysis. SETTING:Tertiary care teaching hospital. PATIENTS:Twenty-one patients with cultures of confirmed ESBL-producing Escheric...

journal_title：Pharmacotherapy

authors： Burgess DS,Hall RG 2nd,Lewis JS 2nd,Jorgensen JH,Patterson JE

更新日期：2003-10-01 00:00:00

abstract：:Atorvastatin calcium is an HMG-coenzyme A (CoA) reductase inhibitor that was approved by the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits the action of HMG-CoA reductase and thereby decreases endogenous cholesterol synthesis, leading to a decrease in circulating low-density li...

journal_title：Pharmacotherapy

authors： Chong PH,Seeger JD

更新日期：1997-11-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...

journal_title：Pharmacotherapy

authors： Seto AC,Kenyon K,Wittkowsky AK

更新日期：2008-09-01 00:00:00

abstract：:We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...

journal_title：Pharmacotherapy

authors： Schumock GT,Butler MG,Meek PD,Vermeulen LC,Arondekar BV,Bauman JL,2002 Task Force on Economic Evaluation of Clinical Pharmacy Services of the American College of Clinical Pharmacy.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Historically, there is perceived pressure to achieve therapeutic levels of tacrolimus quickly after heart transplant (HT). We evaluated the association between time within therapeutic tacrolimus range and time to therapeutic trough and rejection in the 30 days following HT. METHODS:This is a single-center r...

journal_title：Pharmacotherapy

authors： Baker WL,Steiger S,Martin S,Patel N,Radojevic J,Darsaklis K,O'Bara L,Kutzler H,Dougherty J,Feingold A,Hammond J,Fusco D,Gluck JA

更新日期：2019-05-01 00:00:00

abstract：:Behavioral and psychological symptoms of dementia can occur in 60-80% of patients with Alzheimer's disease or other dementing illnesses, and are important in that they are a source of significant caregiver stress and often precipitate nursing home placement. These symptoms, namely, aggression, delusions, hallucination...

journal_title：Pharmacotherapy

authors： Rojas-Fernandez CH,Lanctot KL,Allen DD,MacKnight C

更新日期：2001-01-01 00:00:00

abstract：:Methotrexate, a folic acid antagonist, is being employed more frequently in an attempt to control rheumatoid arthritis that has not responded adequately to conventional therapies. Systemic administration of 7.5-15 mg weekly in a pulse fashion appears to be effective without precipitating serious adverse effects. Conce...

journal_title：Pharmacotherapy

authors： Miller DR,Letendre PW,DeJong DJ,Fiechtner JJ

更新日期：1986-07-01 00:00:00

abstract：:Although studies have shown that patients can distinguish probable adverse drug reactions (ADRs) from adverse clinical events (ACEs) caused by other factors, it is not known whether these attribution judgments add any independent validity to other accepted methods of identifying ADRs, such as physician assessments or ...

journal_title：Pharmacotherapy

authors： Fisher S,Bryant SG,Kent TA,Davis JE

更新日期：1994-03-01 00:00:00

abstract：:Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...

journal_title：Pharmacotherapy

authors： Nemerovski CW,Salinitri FD,Morbitzer KA,Moser LR

更新日期：2012-11-01 00:00:00

abstract：:Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature...

journal_title：Pharmacotherapy

authors： Doligalski CT,Liu EC,Sammons CM,Silverman A,Logan AT

更新日期：2014-11-01 00:00:00

abstract：:Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose requirements and are at greater risk for experiencing warfarin-related adverse...

journal_title：Pharmacotherapy

authors： Kaye JB,Schultz LE,Steiner HE,Kittles RA,Cavallari LH,Karnes JH

更新日期：2017-09-01 00:00:00

abstract：:Information on amphotericin B use patterns and infusion-related adverse events were prospectively collected from 397 hospitalized adults. The methods of initiating amphotericin B varied greatly, with the majority of patients being gradually titrated to a full maintenance dose over 1-5 days. Overall, 71% of patients ex...

journal_title：Pharmacotherapy

authors： Grasela TH Jr,Goodwin SD,Walawander MK,Cramer RL,Fuhs DW,Moriarty VP

更新日期：1990-01-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy. DESIGN:Randomized, prospective, multicenter, open-label study. SETTINGS:University-teaching hospital and veterans he...

journal_title：Pharmacotherapy

authors： Herrington JD,Kwan P,Young RR,Lagow E,Lagrone L,Riggs MW

更新日期：2000-11-01 00:00:00