Abstract:
BACKGROUND:Anti-Müllerian hormone (AMH) is an established marker of ovarian reserve and a good predictor of poor or excessive ovarian response after controlled hyperstimulation. However, it is unclear whether it can predict the ultimate outcome of assisted conception, live birth. We undertook a systematic review and meta-analysis to examine whether AMH is a predictor of live birth in women undergoing assisted conception. METHODS:The study was conducted according to the PRISMA guidelines. PubMed, Embase, Medline, Web of Knowledge and the Cochrane trial register and unpublished literature were searched. Studies fulfilling the eligibility criteria were included in the systematic review and those with extractable data were included in the meta-analysis. Quality assessment was performed with the QUADAS 2 checklist. A summary estimate of diagnostic odds ratio (DOR) was derived using the random effects model for binary data. A hierarchical summary receiver operating characteristic model provided pooled estimates before and after adjusting for age and AMH assay as covariates. RESULTS:Out of 361 non-duplicate studies, 47 were selected; 17 met the eligibility criteria and 13 had extractable data and thus were included in the meta-analysis. Three out of the 13 studies included only women with expected low ovarian reserve and were analysed individually from the remaining 10 to minimize heterogeneity. The DOR for women with unknown ovarian reserve (n = 5764 women) was 2.39 (95% confidence interval (CI): 1.85-3.08). After adjustment for age the DOR was little changed at 2.48 (95% CI: 1.81-3.22) and the DOR adjusted for AMH assay was almost identical at 2.42 (95% CI: 1.86-3.14). For women with expected low ovarian reserve (n = 542 women) the DOR was 4.63 (95% CI: 2.75-7.81). CONCLUSIONS:AMH, independently of age, has some association with predicting live birth after assisted conception and may be helpful when counselling couples before undergoing fertility treatment. However, its predictive accuracy is poor.
journal_name
Hum Reprod Updatejournal_title
Human reproduction updateauthors
Iliodromiti S,Kelsey TW,Wu O,Anderson RA,Nelson SMdoi
10.1093/humupd/dmu003subject
Has Abstractpub_date
2014-07-01 00:00:00pages
560-70issue
4eissn
1355-4786issn
1460-2369pii
dmu003journal_volume
20pub_type
杂志文章,meta分析,评审abstract::Operative hysteroscopy is a relatively new technique that has significantly improved the diagnosis and therapy of abnormal uterine bleeding. At first, the success of operative hysteroscopy in controlling this bleeding seemed extremely high but, with long-term follow-up, a significant failure rate became evident requir...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/4.4.350
更新日期:1998-07-01 00:00:00
abstract::Gestational surrogacy is a treatment option available to women with certain clearly defined medical problems, usually an absent uterus, to help them have their own genetic children. IVF allows the creation of embryos from the gametes of the commissioning couple and subsequent transfer of these embryos to the uterus of...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmg033
更新日期:2003-09-01 00:00:00
abstract::Nitric oxide (NO) is an important mediator of paracrine interactions, especially within the vascular system. It is a powerful inhibitor of platelet aggregation and a potent vasodilator. NO is also a neurotransmitter and it plays a role in cell-mediated cytotoxicity. NO-generating enzymes (nitric oxide synthases, NOS) ...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/4.5.565
更新日期:1998-09-01 00:00:00
abstract::Prior to the development of high-throughput methods for the analysis of differential gene expression, genes required for proper ovarian function were identified on a case-by-case basis. Recently, however, several techniques have been developed that enable investigators to study large-scale changes in gene expression u...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh017
更新日期:2004-05-01 00:00:00
abstract::There has been an improvement in the blastocyst rates achieved following in-vitro embryo production that can largely be attributed to improved embryo culture conditions based on an increased knowledge of the in-vivo environment, as well as the metabolic needs of the embryo. Despite this, in-vitro oocyte maturation (IV...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmg009
更新日期:2003-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmy020
更新日期:2018-09-01 00:00:00
abstract::BACKGROUND Angiogenesis, i.e. the development of new blood vessels from pre-existing ones, represents an integral part in the pathogenesis of endometriosis. During the last decade, an increasing number of studies have therefore focused on the anti-angiogenic treatment of the disease. The present review provides a syst...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dms026
更新日期:2012-11-01 00:00:00
abstract::Ovarian follicular development occurs in a hierarchical manner with each follicle having a unique biochemical composition at any moment in time. It has long been understood that a precise coordination between the growth and maturation of the oocyte and adjacent follicular cells (i.e. somatic cells) is essential in ord...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh061
更新日期:2005-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dms004
更新日期:2012-05-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/1.5.462
更新日期:1995-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/6.5.495
更新日期:2000-09-01 00:00:00
abstract::Pregnancy induces physiological alterations in thyroid function which may make difficult the interpretation of results of thyroid hormone measurement. A state of hyperstimulation of the thyroid gland is common in early pregnancy. In a few cases, thyroid hormone values will deviate from the normal range, which correspo...
journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh008
更新日期:2004-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh052
更新日期:2005-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmm018
更新日期:2007-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/2.5.419
更新日期:1996-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmv016
更新日期:2015-07-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/8.5.395
更新日期:2002-09-01 00:00:00
abstract::BACKGROUND To review the accuracy of multivariate models for the prediction of ovarian reserve and pregnancy in women undergoing IVF compared with the antral follicle count (AFC) as single test. METHODS We performed a computerized MEDLINE and EMBASE search to identify articles published on multivariate models for ovar...
journal_title:Human reproduction update
pub_type: 杂志文章,meta分析
doi:10.1093/humupd/dmn001
更新日期:2008-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmh002
更新日期:2004-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmr028
更新日期:2011-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmn049
更新日期:2009-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/4.6.904
更新日期:1998-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,meta分析,评审
doi:10.1093/humupd/dmt038
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Induced abortion is a common procedure. However, there is marked variation in accessibility of services across England. Accessing abortion services may be difficult, particularly for women who live in remote areas, are in the second trimester of pregnancy, have complex pre-existing conditions or have difficu...
journal_title:Human reproduction update
pub_type: 杂志文章
doi:10.1093/humupd/dmaa026
更新日期:2020-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/2.1.3
更新日期:1996-01-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmi019
更新日期:2005-09-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmv051
更新日期:2016-03-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/dmq008
更新日期:2010-11-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/7.3.331
更新日期:2001-05-01 00:00:00
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journal_title:Human reproduction update
pub_type: 杂志文章,评审
doi:10.1093/humupd/7.4.378
更新日期:2001-07-01 00:00:00