Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract.

Abstract:

:Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.

journal_name

Hum Reprod Update

authors

Fowler DJ,Nicolaides KH,Miell JP

doi

10.1093/humupd/6.5.495

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

495-504

issue

5

eissn

1355-4786

issn

1460-2369

journal_volume

6

pub_type

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