Abstract：
:The pathogenic mechanism underlying the vascular changes in Binswanger's encephalopathy (BE) is unknown. To test whether alterations of the humoral immunity may lead to endothelium damage, we analyzed serum levels of anti-brain endothelium antibodies (ABEA) (IgG and IgM) in 16 BE patients, 19 subjects with ischemic vascular disease without mental deterioration and 18 normal healthy subjects. ABEA IgM were found elevated in 1/16 (6%) BE patients and in 4/19 (21%) patients with cerebrovascular diseases; an increase in ABEA IgG was found in 6/16 (38%) BE patients and in 7/19 (37%) cerebrovascular patients. Association with anti-cardiolipin antibodies (IgG and/or IgM) was found in 50% of BE patients with elevated ABEA and only 10% of those with no increase, whereas high titres of anti-neurofilament antibodies (1:10,000) were detected in 40% and 71% respectively. In BE, ABEA IgG but not IgM showed a trend, although not significant, towards a correlation with the duration of the disease (rs = 0.47; p = 0.07) and significantly correlated with the cognitive function as assessed by the Mini mental state (MMS) score (rs = 0.56; p = 0.02). Higher mean values of the MMS score were found in BE patients with elevated ABEA than in those without (p = 0.04). This difference was not due to language disorders neither to an association with stroke risk factors or anti-neurofilament antibodies. However, there were no significant differences in MMS scores between cerebrovascular patients with ABEA and those without. A "neuro-protective" role is hypothesized for the ABEA in the development of dementia in BE.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Annunziata P,Cioni C,Moschini F,Riccucci A,Guazzi GCdoi
10.1016/0022-510x(94)00215-asubject
Has Abstractpub_date
1995-01-01 00:00:00pages
96-102issue
1eissn
0022-510Xissn
1878-5883pii
0022-510X(94)00215-Ajournal_volume
128pub_type
临床试验,杂志文章abstract：BACKGROUND:Mild cognitive impairment (MCI) is a well-known precursor of Alzheimer's disease (AD) but often also precedes dementia with Lewy bodies (DLB). The early differentiation of DLB from AD is important to delay disease progression. Olfactory dysfunction is a well-known early sign of both AD and Lewy body disorder...
journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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pub_type： 杂志文章,meta分析
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,多中心研究
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：1988-09-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/s0022-510x(02)00269-1
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journal_title：Journal of the neurological sciences
pub_type： 临床试验,杂志文章
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更新日期：2000-09-15 00:00:00
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,评审
doi：10.1016/0022-510x(86)90019-5
更新日期：1986-02-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2008-12-15 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,随机对照试验
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更新日期：2016-11-15 00:00:00
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journal_title：Journal of the neurological sciences
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更新日期：2013-01-15 00:00:00
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更新日期：2014-05-15 00:00:00
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pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1983-10-01 00:00:00
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journal_title：Journal of the neurological sciences
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