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5'-flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan.

Abstract：

:Though the etiology of Parkinson's disease (PD) is unresolved and may be heterogeneous involving both environmental and genetic factors, there are indications that oxidative stress plays an important role in dopaminergic neuronal death. And, it has been reported that inhibition of nitric oxide synthase (NOS) can prevent the destruction of dopaminergic neurons in mammals. To determine if NOS gene polymorphism affects the 5' flanking region that is immediately upstream of the transcription start site lying between the TATA element and CAATT boxes in PD, and differs significantly between patients with PD and normal controls, we studied genetic polymorphism in that region of the neuronal NOS gene in Chinese patients with PD living in Taiwan. The results indicate that the allele size distribution in that region was statistically significantly different between patients with PD and normal.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Lo HS,Hogan EL,Soong BW

doi

10.1016/s0022-510x(01)00666-9

subject

Has Abstract

pub_date

2002-02-15 00:00:00

pages

11-3

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022510X01006669

journal_volume

194

pub_type

杂志文章

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