当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Intrathecal upregulation of IFN-gamma and MIP-1beta in juvenile muscular atrophy of the distal upper extremity.

Intrathecal upregulation of IFN-gamma and MIP-1beta in juvenile muscular atrophy of the distal upper extremity.

Abstract：

:Juvenile muscular atrophy of the distal upper extremity (JMADUE) is associated with airway allergy and hyperIgEaemia, suggesting the involvement of immunological processes. In this study we aimed to clarify the changes in various cytokines/chemokines in cerebrospinal fluid (CSF) from JMADUE patients. We simultaneously measured 17 cytokines/chemokines in sera and CSF from 6 patients with JMADUE before treatment and from 14 patients with cervical spondylosis (CS) as a disease control (mean age at examination 23+/-7 and. 57+/-16 years, respectively), using a fluorescent bead-based immunoassay. We also assayed CSF from a JMADUE patient before and after plasma exchanges. In sera, only an increase of MIP-1beta (CCL3) in the JMADUE patients had a marginal significance as compared with the CS patients. In the CSF, IFN-gamma and MIP-1beta (CCL3) were significantly elevated in JMADUE patients compared with controls (1.5 and 2-fold increases, respectively), while no other cytokines/chemokines showed any significant differences. Moreover, the upregulated cytokines decreased after plasma exchanges in accord with improvement of distal upper limb weakness. The intrathecal upregulation of proinflammatory Th1 cytokines/chemokines, such as IFN-gamma and MIP-1beta (CCL3), in the CSF of JMADUE patients indicates the possible involvement of intrathecal immunological processes in this condition.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Tanaka M,Ishizu T,Ochi H,Kawano Y,Ohyagi Y,Kira J

doi

10.1016/j.jns.2008.07.020

subject

Has Abstract

pub_date

2008-12-15 00:00:00

pages

74-7

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(08)00368-7

journal_volume

275

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Does education modify motor compensation in Parkinson's disease?

    abstract：BACKGROUND:In Alzheimer's disease, higher educational attainment is associated with fewer cognitive deficits despite similar pathological lesions. In animal models of Parkinson's disease (PD), enhanced levels of cognitive and physical stimulation can reduce motor deficits due to dopaminergic neuronal loss. Therefore, i...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.01.030

    authors： Sunwoo MK,Hong JY,Lee JJ,Lee PH,Sohn YH

    更新日期：2016-03-15 00:00:00

  • Hallucinations and the spectrum of psychosis in Parkinson's disease.

    abstract：:Hallucinations and psychosis can be a part of Parkinson's disease and are considered to be a nonmotor symptom or a neuropsychiatric complication of the disease. Hallucinations of different modalities and delusions can occur beyond the common visual hallucinations. The various types of hallucinations and psychotic symp...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2017.01.014

    authors： Frei K,Truong DD

    更新日期：2017-03-15 00:00:00

  • Correlations of platelet-leukocyte aggregates with P-selectin S290N and P-selectin glycoprotein ligand-1 M62I genetic polymorphisms in patients with acute ischemic stroke.

    abstract：BACKGROUND:Platelet-leukocyte aggregations (PLA) play key roles in acute ischemic stroke (AIS) process and they are formed by the combination of P-selectin (SELP) expressed on the surface of the platelet membranes with P-selectin glycoprotein ligand-1(PSGL-1) expressed on the surface of the leukocytes. There are geneti...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.05.046

    authors： Tao L,Changfu W,Linyun L,Bing M,Xiaohui H

    更新日期：2016-08-15 00:00:00

  • Combination of myotonic dystrophy and hereditary motor and sensory neuropathy.

    abstract：:Myotonic Dystrophy Type 1 (DM1) in combination with demyelinating neuropathy is very rare in literature. In this study, DM1 and demyelinating neuropathy were demonstrated clinically and electromyographically in a 43-year-old female patient from Turkey. In the patient an expanded CTG repeat in the Myotonic Dystrophy Pr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.09.028

    authors： Kurt S,Karaer H,Kaplan Y,Akat I,Battaloglu E,Eruslu D,Basak AN

    更新日期：2010-01-15 00:00:00

  • Expression of the human groEL stress-protein homologue in the brain and spinal cord.

    abstract：:A monoclonal antibody (ML30), previously shown to identify a human mitochondrial protein epitope homologous with the groEL heat-shock protein of bacteria (hsp60), was used in an immunohistochemical survey of the central nervous system in patients dying with no evidence of neurological disease and in tissue from patien...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(93)90111-b

    authors： Martin JE,Swash M,Mather K,Leigh PN

    更新日期：1993-09-01 00:00:00

  • Herpes simplex virus antibodies in patients with Parkinson's disease.

    abstract：:Sera from 40 patients with idiopathic Parkinson's disease and their age- and sex-matched controls were assayed for immunoglobulin G (IgG) antibodies against herpes simplex virus (HSV) type 1-induced cell surface antigens with the indirect immunofluorescent test. An increased level of HSV antibodies was found among the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90017-5

    authors： Marttila RJ,Rinne UK

    更新日期：1978-02-01 00:00:00

  • Early tolerability and safety of fingolimod in clinical practice.

    abstract：BACKGROUND:Fingolimod is approved by the U.S. Food and Drug Administration to reduce relapses and disability progression in relapsing forms of MS. Several screening studies and a first-dose observation (FDO) period are recommended due to adverse effects observed in clinical trials. OBJECTIVE:The objective of this stud...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.09.009

    authors： Ontaneda D,Hara-Cleaver C,Rudick RA,Cohen JA,Bermel RA

    更新日期：2012-12-15 00:00:00

  • Class II antigen expression in peripheral neuropathies.

    abstract：:The expression of class II antigen was studied in sural nerve biopsies from patients with peripheral neuropathies. These included patients with chronic demyelinating polyradiculoneuropathy (CIDP), non-immune mediated neuropathies of diverse etiologies and controls without evidence of neuropathy. The major finding in C...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90065-f

    authors： Mitchell GW,Williams GS,Bosch EP,Hart MN

    更新日期：1991-04-01 00:00:00

  • Experience of pediatric stroke from a tertiary medical center in North India.

    abstract：OBJECTIVE:The etiology and outcome of pediatric stroke differs in different geographical regions and there is no comprehensive study from India. This study evaluates the etiology, type and predictors of outcome of pediatric stroke from Northern India. METHODS:79 stroke patients aged 1month to 18years managed during 20...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.11.020

    authors： Kalita J,Goyal G,Misra UK

    更新日期：2013-02-15 00:00:00

  • White matter lesions and depression in patients with Parkinson's disease.

    abstract：:Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investig...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.07.021

    authors： Petrovic IN,Stefanova E,Kozic D,Semnic R,Markovic V,Daragasevic NT,Kostic VS

    更新日期：2012-11-15 00:00:00

  • Hereditary hypertrophic neuropathy in the trembler mouse. Part 2. Histopathological studies: electron microscopy.

    abstract：:The Trembler mouse suffers from a dominantly inherited hypertrophic neuropathy. Electron microscopy, including a quantitative analysis of myelination was performed on the nerves of Trembler mice from birth to senility and compared with the findings in control mice. Axons in adult Trembler nerves were thinly myelinated...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(76)90139-8

    authors： Low PA

    更新日期：1976-12-01 00:00:00

  • An initial experience of machine learning based on multi-sequence texture parameters in magnetic resonance imaging to differentiate glioblastoma from brain metastases.

    abstract：PURPOSE:To evaluate the performance of a machine learning method based on texture parameters in conventional magnetic resonance imaging (MRI) in differentiating glioblastoma (GB) from brain metastases (METs). MATERIALS AND METHODS:In this retrospective study conducted between November 2008 and July 2017, we included 7...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116514

    authors： Tateishi M,Nakaura T,Kitajima M,Uetani H,Nakagawa M,Inoue T,Kuroda JI,Mukasa A,Yamashita Y

    更新日期：2020-03-15 00:00:00

  • Two-dimensional immunoelectrophoresis of unconcentrated cerebrospinal fluid.

    abstract：:The two-dimensional immunoelectrophoresis on cellulose acetate, already utilized for serum proteins, has been applied to CSF proteins. The technical modifications which allow the use of unconcentrated CSF are described. By utilizing a particularly suitable supporting medium, a good separation of proteins is achieved; ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90203-4

    authors： Baggio G,Bertolotto A,Moretti MG,Palmucci LC

    更新日期：1978-07-01 00:00:00

  • Aluminum affects interconnections between aggregates of cultured hippocampal neurons. Neurotoxicity of aluminum in vitro.

    abstract：:The effect of aluminum (Al) was studied in an in vitro system of cultured hippocampal neurons from fetal rats in a chemically defined medium. Neuronal aggregates interconnected by neurites were detected light and electron microscopically in control and Al-treated cultures. In the Al-treated cultures disruptions of the...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(89)90186-x

    authors： van Welsum RA,van der Voet GB,Marani E,van Keep JP,de Wolff FA

    更新日期：1989-11-01 00:00:00

  • Clinical and molecular characterization of hereditary spastic paraplegias: A next-generation sequencing panel approach.

    abstract：BACKGROUND:Molecular diagnosis of hereditary spastic paraplegias (HSP) is a difficult task due to great clinical and genetic heterogeneity. We aimed to characterize clinical and molecular findings of HSP families from Rio Grande do Sul, Brazil; and to evaluate the diagnostic yield of a next-generation sequencing (NGS) ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2017.10.010

    authors： Burguez D,Polese-Bonatto M,Scudeiro LAJ,Björkhem I,Schöls L,Jardim LB,Matte U,Saraiva-Pereira ML,Siebert M,Saute JAM

    更新日期：2017-12-15 00:00:00

  • CYP2D6 phenotypes and Parkinson's disease risk: a meta-analysis.

    abstract：BACKGROUND:CYP2D6 polymorphisms have been reported to be associated with Parkinson's disease (PD) susceptibility, but the results of these previous studies were inconsistent. OBJECTIVES:To explore whether PD patients with CYP2D6 gene variation have different risk to PD to those with normal function of CYP2D6. METHODS...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jns.2013.10.030

    authors： Lu Y,Peng Q,Zeng Z,Wang J,Deng Y,Xie L,Mo C,Zeng J,Qin X,Li S

    更新日期：2014-01-15 00:00:00

  • The pattern of E2F1 and c-myb immunoreactivities in the CA1 region is different from those in the CA2/3 region of the gerbil hippocampus induced by transient ischemia.

    abstract：:In this study, we examined transient ischemia-induced changes in transcription factor E2F1 and c-myb expressions in the gerbil hippocampus after 5 min of transient forebrain ischemia. E2F1 immunoreactivity significantly increased in the CA1 region 6-12 h after ischemia/reperfusion. c-myb immunoreactivity increased mai...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.05.048

    authors： Hwang IK,Yoo KY,Cho BM,Hwang HS,Kim SM,Oh SM,Choi SK,Hwang DY,Won MH,Moon SM

    更新日期：2006-09-25 00:00:00

  • Treatment and outcome of myasthenia gravis: retrospective multi-center analysis of 470 Japanese patients, 1999-2000.

    abstract：:To clarify the current status of treatments and outcomes of patients with myasthenia gravis (MG) in Japan, a total of 470 patients (164 men and 306 women; mean age 41 years) were recruited from 19 Japanese tertiary medical centers in 1999-2000. Thymectomy was performed in 319 (68%) of the patients. Patients who receiv...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jns.2003.09.016

    authors： Kawaguchi N,Kuwabara S,Nemoto Y,Fukutake T,Satomura Y,Arimura K,Osame M,Hattori T,Study Group for Myasthenia Gravis in Japan.

    更新日期：2004-09-15 00:00:00

  • Increased intracranial volume in Parkinson's disease.

    abstract：BACKGROUND:Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that can be difficult to diagnose and distinguish from each other. STUDY AIMS AND METHODS: Patients with PD and MSA and controls were studied with magnetic resonance imaging (MRI) using tissue segmentation and outlining...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2005.07.013

    authors： Krabbe K,Karlsborg M,Hansen A,Werdelin L,Mehlsen J,Larsson HB,Paulson OB

    更新日期：2005-12-15 00:00:00

  • Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC.

    abstract：:A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an overall improvement in function. Chondroitin sulphate proteoglycans ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.06.011

    authors： Carwardine D,Wong LF,Fawcett JW,Muir EM,Granger N

    更新日期：2016-08-15 00:00:00

  • Familial intermittent ataxia with possible X-linked recessive inheritance. Two patients with abnormal pyruvate metabolism and a response to acetazolamide.

    abstract：:Five males in one kindred suffered from intermittent ataxia and one female may have been more mildly affected. The pattern of inheritance strongly suggests X-linkage. Cerebral pathology in one case had some features of Leigh's disease. A defect in pyruvate metabolism was found in two cases. Acetazolamide gave a tempor...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(84)90059-5

    authors： Livingstone IR,Gardner-Medwin D,Pennington RJ

    更新日期：1984-04-01 00:00:00

  • Arteriolosclerotic leucoencephalopathy in the elderly and its relation to white matter lesions in Binswanger's disease, multi-infarct encephalopathy and Alzheimer's disease.

    abstract：:Arteriolosclerotic leucoencephalopathy in the elderly (ALE) is characterized by white matter lesions associated with atherosclerosis and arteriolosclerosis. Mild lesions are focal and probably represent early status cribosus or incomplete lacunar infarcts. Moderate and severe lesions are diffuse areas of demyelination...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90180-u

    authors： Ferrer I,Bella R,Serrano MT,Martí E,Guionnet N

    更新日期：1990-08-01 00:00:00

  • Kidney function changes and their relation with the progression of cerebral small vessel disease and cognitive decline.

    abstract：AIMS:We aimed to study whether worsening in markers of kidney function parallels the progression in cerebral small vessel disease (cSVD) and cognitive decline. METHODS:Data from the ISSYS (Investigating Silent Strokes in Hypertensives Study), a longitudinal population-based study in hypertensives aged 50-70 and dement...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116635

    authors： Jiménez-Balado J,Riba-Llena I,Pizarro J,Palasí A,Penalba A,Ramírez C,Maisterra O,Espinel E,Ramos N,Pujadas F,Serón D,Delgado P

    更新日期：2020-02-15 00:00:00

  • Parkinson's disease, cognition and aging. Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment.

    abstract：:Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(96)00161-x

    authors： Elwan OH,Baradah OH,Madkour O,Elwan H,Hassan AA,Elwan F,Mahfouz M,Ali A,Fahmy M

    更新日期：1996-11-01 00:00:00

  • The spinal cord in lightning injury: a report of two cases.

    abstract：:We present 2 patients in whom the predominant neurological complication following lightning strike was spinal cord injury. One patient, who was followed for 5 years, showed clinical, electrophysiologic and MRI evidence of cervical spinal cord injury. This patient had significant recovery, which in part, may be related...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.09.020

    authors： Lakshminarayanan S,Chokroverty S,Eshkar N,Grewal R

    更新日期：2009-01-15 00:00:00

  • The contribution of wall shear stress insult to the growth of small unruptured cerebral aneurysms in longitudinal 3D-TOF-MRA.

    abstract：OBJECTIVE:Aneurysm growth is a risk factor for rupture, however the detailed mechanism remains unclear. The present study was performed to identify whether hemodynamic insult could prompt small unruptured aneurysms to grow. METHODS:Six pairs of unruptured small (<5 mm) cerebral aneurysms from patients followed with lo...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116798

    authors： Sun L,Wang J,Li M,Li M,Zhu Y

    更新日期：2020-06-15 00:00:00

  • Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction.

    abstract：:gamma-Aminobutyric acid (GABA), substance P and dopamine concentrations and choline acetyltransferase (ChAT) activity were measured in post-mortem cerebrocortical and basal ganglial areas of 14 controls and 4 patients with pathologically verified Pick's disease (1 classic case and 3 cases of the generalized form). GAB...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(88)90020-2

    authors： Kanazawa I,Kwak S,Sasaki H,Muramoto O,Mizutani T,Hori A,Nukina N

    更新日期：1988-01-01 00:00:00

  • What do we really know about amyotrophic lateral sclerosis?

    abstract：:The cause of amyotrophic lateral sclerosis is unknown. In this review clinical and scientific data that are pertinent to understanding this disease are reviewed. There are currently several major controversies concerning the possible role of immunological factors, genetic factors, environmental toxins, and viral infec...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0022-510x(92)90258-m

    authors： Swash M,Schwartz MS

    更新日期：1992-11-01 00:00:00

  • Histopathological evidence that hippocampal atrophy following status epilepticus is a result of neuronal necrosis.

    abstract：:Medial temporal lobe epilepsy is commonly associated with hippocampal atrophy on MRI and hippocampal sclerosis on histopathological examination of surgically-resected specimens. Likewise, it is well-established that prolonged seizures and status epilepticus can lead to hippocampal edema as noted on MRI. In this paper,...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.08.016

    authors： Kumar G,Mittal S,Moudgil SS,Kupsky WJ,Shah AK

    更新日期：2013-11-15 00:00:00

  • Does ethanol damage the blood--brain barrier?

    abstract：:The permeability of the blood--brain barrier has been measured using a technique which is independent of blood flow and is sufficiently accurate to monitor the penetration of weakly permeant substances. The permeability of the blood--brain barrier to [14C]sucrose has been measured in rats anaesthetised with either ure...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90043-5

    authors： Phillips SC

    更新日期：1981-04-01 00:00:00