Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction.

Abstract:

:gamma-Aminobutyric acid (GABA), substance P and dopamine concentrations and choline acetyltransferase (ChAT) activity were measured in post-mortem cerebrocortical and basal ganglial areas of 14 controls and 4 patients with pathologically verified Pick's disease (1 classic case and 3 cases of the generalized form). GABA and substance P levels in the substantia nigra and the globus pallidus were generally decreased, corresponding to the moderate to severe loss of small neurones in the striatum. ChAT activities in the striatum varied from case to case, in proportion to various degrees of loss of large neurones in the striatum. These neurotransmitter abnormalities in Pick's disease were exactly the same as those in Huntington's disease. However, dopamine concentrations were markedly reduced in the striatum in Pick's disease, whereas striatal dopamine in Huntington's disease is reported to be increased. A dopamine reduction in the striatum of Pick's disease was more disproportionately prominent than expected for various degrees of nigral cell loss. This may be one of the important factors which prevents the generation of choreic movements in Pick's disease in spite of definite striatal atrophy similar to Huntington's disease.

journal_name

J Neurol Sci

authors

Kanazawa I,Kwak S,Sasaki H,Muramoto O,Mizutani T,Hori A,Nukina N

doi

10.1016/0022-510x(88)90020-2

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

63-74

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(88)90020-2

journal_volume

83

pub_type

杂志文章
  • Quality of life and psychological impact in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization.

    abstract:OBJECTIVES:Surgical treatment for adult hemorrhagic moyamoya disease (MMD) remains controversial. A large proportion of Chinese adult patients with hemorrhagic MMD still choose conservative treatment. In this study, we investigated to assess psychological function and quality of life (QoL) in adult patients with hemorr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2013.02.010

    authors: Su SH,Hai J,Zhang L,Wu YF,Yu F

    更新日期:2013-05-15 00:00:00

  • Association of ankle-brachial index level with stroke.

    abstract:BACKGROUND:There are conflicting data on the relationship between peripheral arterial disease (PAD) as defined by an ankle-brachial index (ABI) of <0.9 and stroke risk, and these prior data have largely focused on a single race or gender. Furthermore, the association between subsequent ABIs above the established 0.9 th...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2008.08.016

    authors: Ovbiagele B

    更新日期:2009-01-15 00:00:00

  • Blood pressure augmentation in acute ischemic stroke.

    abstract::Although control of hypertension is established as an important factor in the primary and secondary prevention of stroke, management of blood pressure in the setting of acute ischemic stroke remains controversial. Given limited data, the general consensus is that there is no proven benefit to lowering blood pressure i...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2007.04.033

    authors: Wityk RJ

    更新日期:2007-10-15 00:00:00

  • Blink reflex in patients with hemispheric cerebrovascular accident (CVA). Blink reflex in CVA.

    abstract::A blink reflex consists of an early unilateral component, R1, and a late bilateral component, R2. During an acute phase of hemispheric cerebrovascular accident, R1 and R2 were abnormal in 30 and 50 of 66 patients, respectively. Paired stimuli usually corrected R1 but not R2, which was profoundly suppressed. The discre...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(85)90018-8

    authors: Kimura J,Wilkinson JT,Damasio H,Adams HR Jr,Shivapour E,Yamada T

    更新日期:1985-01-01 00:00:00

  • Parkinson's disease, cognition and aging. Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment.

    abstract::Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(96)00161-x

    authors: Elwan OH,Baradah OH,Madkour O,Elwan H,Hassan AA,Elwan F,Mahfouz M,Ali A,Fahmy M

    更新日期:1996-11-01 00:00:00

  • Histocompatibility antigens associated with motor neurone disease.

    abstract::The distribution of histocompatibility antigens was studied in 44 patients with motor neurone disease (MND). An unusually high incidence of HLA antigens A2 and A28 was found, compared to a control population. ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(77)90236-2

    authors: Behan PO,Dick HM,Durward WF

    更新日期:1977-06-01 00:00:00

  • Tumefactive demyelinating lesions as a first clinical event: Clinical, imaging, and follow-up observations.

    abstract:BACKGROUND:Tumefactive demyelinating lesions (TDLs) are associated with a variety of demyelinating diseases in the central nervous system (CNS). However, there are no current guidelines describing how to classify and treat patients with this rare phenotype. Thus, the present study aimed to determine the long-term evolu...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2015.08.034

    authors: Jeong IH,Kim SH,Hyun JW,Joung A,Cho HJ,Kim HJ

    更新日期:2015-11-15 00:00:00

  • The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery.

    abstract:BACKGROUND:The mechanisms for improved cognitive function post-bariatric surgery are not well understood. Markers of kidney and liver function (i.e., cystatin C and alkaline phosphatase (ALP)) are elevated in obese individuals and associated with poor neurocognitive outcomes in other samples. Bariatric surgery can impr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2014.07.037

    authors: Alosco ML,Spitznagel MB,Strain G,Devlin M,Cohen R,Crosby RD,Mitchell JE,Gunstad J

    更新日期:2014-10-15 00:00:00

  • Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.

    abstract::The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identifie...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2009.09.009

    authors: Palace J

    更新日期:2009-11-15 00:00:00

  • Inhibition of synaptosomal [3H]glutamate uptake and [3H]glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro.

    abstract::Synaptosomes and plasma membrane preparations from brain of 30-day-old rats were incubated with glutaric acid at final concentrations ranging from 10 nM to 1 mM for the determination of glutamate uptake and binding, respectively. [3H]Glutamate uptake into synaptosomes was inhibited by approximately 50% by 1 mM glutari...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(99)00307-x

    authors: Porciúncula LO,Dal-Pizzol A Jr,Coitinho AS,Emanuelli T,Souza DO,Wajner M

    更新日期:2000-02-15 00:00:00

  • Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST).

    abstract:INTRODUCTION:Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST) to assess the relationship between stroke severity, early recovery, outcome and OCSP syndrome...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jns.2006.12.016

    authors: Sprigg N,Gray LJ,Bath PM,Lindenstrøm E,Boysen G,De Deyn PP,Friis P,Leys D,Marttila R,Olsson JE,O'Neill D,Ringelstein EB,van der Sande JJ,Turpie AG,TAIST Investigators.

    更新日期:2007-03-15 00:00:00

  • Central nervous system AIDS.

    abstract::The retrovirus that causes the acquired immunodeficiency syndrome (AIDS) has two targets: the immune system and the nervous system. Central nervous system (CNS) manifestations of AIDS are protean. This review describes the opportunistic infections and malignancies that affect the nervous system in AIDS, and discusses ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0022-510x(89)90013-0

    authors: Tucker T

    更新日期:1989-02-01 00:00:00

  • Acute canine idiopathic polyneuropathy. A Guillain-Barré-like syndrome in dogs.

    abstract::We evaluated 14 previously healthy dogs with acute progressive flaccid quadriparesis and hyporeflexia. Electrophysiological and pathological features indicated varying degrees of motor-sensory polyneuropathy with some demyelination. Perivenular cellular infiltrations were present in roots of one autopsied case. Recove...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(82)90147-2

    authors: Northington JW,Brown MJ

    更新日期:1982-11-01 00:00:00

  • Risk factors, etiology, and outcome of ischemic stroke in young adults: A Japanese multicenter prospective study.

    abstract:PURPOSE:This study aimed to evaluate the risk factors, etiology, and outcomes of ischemic stroke (IS) in Japanese young adults. METHODS:This was a prospective multicenter study. We enrolled patients aged 16 to 55 years with IS within seven days of the onset of symptoms. We assessed the demographic data, risk factors, ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2020.117068

    authors: Kono Y,Terasawa Y,Sakai K,Iguchi Y,Nishiyama Y,Nito C,Suda S,Kimura K,Kanzawa T,Imafuku I,Nakayama T,Ueda M,Iwanaga T,Kono T,Yamashiro K,Tanaka R,Okubo S,Nakajima M,Nakajima N,Mishina M,Yaguchi H,Oka H,Suzuki

    更新日期:2020-10-15 00:00:00

  • Overview of sleep disturbances and their management in Parkinson plus disorders.

    abstract::Sleep disturbance is one of the commonly reported non-motor symptoms in patients with Parkinson's disease (PD) as well as in Parkinson plus disorders such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS). Although there is a wealth...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2020.116891

    authors: Bhattacharya A,Lenka A,Stezin A,Kamble N,Pal PK

    更新日期:2020-08-15 00:00:00

  • Follow-on products for treatment of multiple sclerosis in Latin America: An update.

    abstract::Both proprietary and non-proprietary medicines are expected to undergo rigorous pre-approval testing and both should meet stringent health authority regulatory requirements related to quality to obtain approval. Non-proprietary (also known as copy or generic) medicines, which base their authorization and use on the pr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2017.08.3242

    authors: Correale J

    更新日期:2017-10-15 00:00:00

  • The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.

    abstract::The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN), 3-hydroxykynurenine (3-HK) and picolinic acid (PIC). The former two are neuroactive, while the latter two are molecules with pro-oxidants an...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.jns.2012.08.005

    authors: Tan L,Yu JT,Tan L

    更新日期:2012-12-15 00:00:00

  • Immune regulation within the central nervous system.

    abstract::The brain constitutes an environment that is specifically designed to accommodate, regulate and shape immune responses. On one hand, the central nervous system (CNS) has traditionally been regarded as an immunologically privileged organ, owing to local tissue barrier and immunosuppressive microenvironment. On the othe...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0022-510x(98)00049-5

    authors: Xiao BG,Link H

    更新日期:1998-04-15 00:00:00

  • Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain.

    abstract::Phenylketonuria (PKU) is a recessive autosomal disorder caused by a severe deficiency of phenylalanine-4-hydroxilase activity which leads to the accumulation of L-phenylalanine (Phe) in the tissues and plasma of patients. The main clinical features are retarded development and intellectual impairment. Recent studies h...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2010.01.016

    authors: Moraes TB,Zanin F,da Rosa A,de Oliveira A,Coelho J,Petrillo F,Wajner M,Dutra-Filho CS

    更新日期:2010-05-15 00:00:00

  • Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome.

    abstract::Two transgenic strains of mutant mice lacking hypoxanthine-guanidine phosphoribosyltransferase (HPRT) activity were examined behaviorally and neurochemically for phenotypic similarity to the human Lesch-Nyhan syndrome. In this syndrome, male children markedly deficient in the enzyme HPRT develop self-mutilation and se...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(88)90099-8

    authors: Finger S,Heavens RP,Sirinathsinghji DJ,Kuehn MR,Dunnett SB

    更新日期:1988-09-01 00:00:00

  • Circulating plasma factors in Parkinson's disease enhance nitric oxide release of normal human neutrophils.

    abstract::Nitric oxide (*NO)-mediated toxicity has been involved in neurodegenerative diseases, including Parkinson's disease (PD). We have recently reported an increase of about 50% in *NO production rate in PMA-activated polymorphonuclear leukocytes (PMN) from either newly diagnosed or chronically treated PD patients. As humo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(99)00079-9

    authors: Gatto EM,Riobó NA,Carreras MC,Schöpfer FJ,Pargament GA,Poderoso JJ

    更新日期:1999-05-01 00:00:00

  • Immunocytochemical studies on the vimentin distribution and cell proliferation of fibroblasts in patients with Friedreich's ataxia.

    abstract::Fibroblasts obtained from patients with Friedreich's ataxia and normal control subjects were studied by immunocytochemistry for intermediate filament vimentin and also for in vitro proliferation. Trypsinized cells were seeded on coverslips and incubated for 1.5 h and 24 h. The expression of vimentin in cells was inves...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(93)90168-x

    authors: Willers I,Ressler B,Singh S,Koeppen AH

    更新日期:1993-07-01 00:00:00

  • Immunofluorescence studies in a case of rheumatoid neuropathy.

    abstract::Findings in a sural nerve biopsy from a patient with rheumatoid neuropathy are reported. Inflammatory changes in different stages were observed in epineurial arterioles. Arterioles with fibrinoid necrosis contained IgG, IgM, rheumatoid factor and complement. The same substances were found at the inner site of the peri...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/0022-510x(77)90128-9

    authors: Van Lis JM,Jennekens FG

    更新日期:1977-09-01 00:00:00

  • Encephalitis related to primary varicella-zoster virus infection in immunocompetent children.

    abstract:INTRODUCTION:Encephalitis is a rare complication of primary varicella-zoster virus (VZV) infection in immunocompetent children. METHODS:The clinical and laboratory findings of two girls with VZV-related encephalitis are reported. RESULTS:Both children presented with focal epileptic seizures, corresponding to cortical...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/s0022-510x(02)00017-5

    authors: Häusler M,Schaade L,Kemény S,Schweizer K,Schoenmackers C,Ramaekers VT

    更新日期:2002-03-30 00:00:00

  • Non-ataxic manifestations of Spinocerebellar ataxia-2, their determinants and predictors.

    abstract:INTRODUCTION:To evaluate the non-ataxic clinical manifestations in genetically proven Spinocerebellar ataxia 2 (SCA2) and identify their determinants and predictors. METHODS:Seventy-three subjects with genetically proven SCA2 were evaluated clinically for the common non-ataxic manifestations. Based on the presence or ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2018.08.024

    authors: Stezin A,Venkatesh SD,Thennarasu K,Purushottam M,Jain S,Yadav R,Pal PK

    更新日期:2018-11-15 00:00:00

  • Poor recovery after the first two attacks of multiple sclerosis is associated with poor outcome five years later.

    abstract:OBJECTIVE:Examine the relative importance of several risk factors for progression, in a large sample of MS patients. METHODS:Using a retrospective design in a single university-based MS treatment center, we studied 207 patients with relapsing remitting MS diagnosed, treated at our center, evaluated within one year of ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2010.02.008

    authors: Scott TF,Schramke CJ

    更新日期:2010-05-15 00:00:00

  • Lessons from randomised direct comparative trials.

    abstract::For over a decade, four immunomodulatory therapies have been available for the treatment of relapsing remitting multiple sclerosis. However, few direct comparative data were available to facilitate the choice of treatment. This choice has been influenced by the perception that interferon-beta preparations have greater...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/S0022-510X(09)70007-3

    authors: Achiron A,Fredrikson S

    更新日期:2009-02-01 00:00:00

  • Ifosfamide related encephalopathy: the need for a timely EEG evaluation.

    abstract:BACKGROUND:Ifosfamide is an alkylating agent useful in the treatment of a wide range of cancers including sarcomas, lymphoma, gynecologic and testicular cancers. Encephalopathy has been reported in 10-40% of patients receiving high-dose IV ifosfamide. OBJECTIVE:To highlight the role of electroencephalogram (EEG) in th...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2013.10.018

    authors: Feyissa AM,Tummala S

    更新日期:2014-01-15 00:00:00

  • Effects of CDP-choline on the recovery of patients with head injury.

    abstract::A single blind randomized study has been conducted in 216 patients with severe or moderate head injury, with the aim of comparing the evolution of those that received only conventional treatment with the evolution of those treated with CDP-choline. Our results indicate that CDP-choline improves the global outcome of p...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0022-510x(91)90003-p

    authors: Calatayud Maldonado V,Calatayud Pérez JB,Aso Escario J

    更新日期:1991-07-01 00:00:00

  • Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model.

    abstract::Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury has neuroprotective benefits in animal models, including enhancing functional recovery after ischemic stroke. However, the mechanism underlying this effect remains unclear. To clarify this critical issue,...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章

    doi:10.1016/j.jns.2014.10.022

    authors: Yu K,Wu Y,Zhang Q,Xie H,Liu G,Guo Z,Li F,Jia J,Kuang S,Hu R

    更新日期:2014-12-15 00:00:00