Abstract:
:gamma-Aminobutyric acid (GABA), substance P and dopamine concentrations and choline acetyltransferase (ChAT) activity were measured in post-mortem cerebrocortical and basal ganglial areas of 14 controls and 4 patients with pathologically verified Pick's disease (1 classic case and 3 cases of the generalized form). GABA and substance P levels in the substantia nigra and the globus pallidus were generally decreased, corresponding to the moderate to severe loss of small neurones in the striatum. ChAT activities in the striatum varied from case to case, in proportion to various degrees of loss of large neurones in the striatum. These neurotransmitter abnormalities in Pick's disease were exactly the same as those in Huntington's disease. However, dopamine concentrations were markedly reduced in the striatum in Pick's disease, whereas striatal dopamine in Huntington's disease is reported to be increased. A dopamine reduction in the striatum of Pick's disease was more disproportionately prominent than expected for various degrees of nigral cell loss. This may be one of the important factors which prevents the generation of choreic movements in Pick's disease in spite of definite striatal atrophy similar to Huntington's disease.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Kanazawa I,Kwak S,Sasaki H,Muramoto O,Mizutani T,Hori A,Nukina Ndoi
10.1016/0022-510x(88)90020-2subject
Has Abstractpub_date
1988-01-01 00:00:00pages
63-74issue
1eissn
0022-510Xissn
1878-5883pii
0022-510X(88)90020-2journal_volume
83pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of the neurological sciences
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更新日期:1993-07-01 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:1977-09-01 00:00:00
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更新日期:2018-11-15 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-15 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-07-01 00:00:00
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更新日期:2014-12-15 00:00:00