Abstract：
:To clarify the current status of treatments and outcomes of patients with myasthenia gravis (MG) in Japan, a total of 470 patients (164 men and 306 women; mean age 41 years) were recruited from 19 Japanese tertiary medical centers in 1999-2000. Thymectomy was performed in 319 (68%) of the patients. Patients who received thymectomy were younger (p = 0.01) and had more severe disabilities (p < 0.01) than patients without thymectomy. Irrespective of receiving thymectomy, most of the patients were administered corticosteroids (64%), other immunosuppressive agents (10%), or cholinesterase inhibitors (86%). Of 395 patients followed up for more than 12 months after treatment (mean 8.0 years), 30% (34% of thymectomized and 21% of non-thymectomized patients) were in remission (no symptoms with/without medication), 34% had only ocular symptoms, and the remaining 35% still had weakness of bulbar or limb muscles at the end of follow-up. The prognosis of MG in Japan was generally favorable, but despite the frequent use of thymectomy and immunosuppressive treatments, approximately one-third of patients still had generalized weakness. More effective or intensive treatments are required to improve the prognosis.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Kawaguchi N,Kuwabara S,Nemoto Y,Fukutake T,Satomura Y,Arimura K,Osame M,Hattori T,Study Group for Myasthenia Gravis in Japan.doi
10.1016/j.jns.2003.09.016subject
Has Abstractpub_date
2004-09-15 00:00:00pages
43-7issue
1-2eissn
0022-510Xissn
1878-5883pii
S0022510X04001819journal_volume
224pub_type
杂志文章,多中心研究abstract：:The phase of rapid reduction of isometric strength in single muscle groups was identified and its slope was calculated in patients studied with the TQNE method. This parameter was studied in the extremities and in respiration in 4 ALS patients and 4 PMA (progressive spinal muscle atrophy) patients. The slopes of the s...
journal_title：Journal of the neurological sciences
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doi：10.1016/0022-510x(96)00121-9
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
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doi：10.1016/0022-510x(79)90005-4
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journal_title：Journal of the neurological sciences
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doi：10.1016/j.jns.2007.04.021
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journal_title：Journal of the neurological sciences
pub_type： 临床试验,杂志文章
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更新日期：1995-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
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doi：10.1016/0022-510x(76)90251-3
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章,多中心研究
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 临床试验,杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
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更新日期：2008-07-15 00:00:00
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journal_title：Journal of the neurological sciences
pub_type： 杂志文章
doi：10.1016/s0022-510x(00)00383-x
更新日期：2000-10-01 00:00:00
