Corticosteroids treatment.


:Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of clinical attacks. Chronic administrations of Cs significantly diminish the formation of T1 hypointense lesions and the progression of brain atrophy. As for patients with secondary progressive MS treatment with Cs delays the time to onset of sustained disability. Finally the association between methylprednisolone and interferon beta (IFNbeta) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNbeta in patients with RRMS.


J Neurol Sci


Pozzilli C,Marinelli F,Romano S,Bagnato F




Has Abstract


2004-08-15 00:00:00














  • Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: a [99mTc]-d,l-HMPAO SPECT study.

    abstract::We investigated regional cerebral blood flow (rCBF) using the [99mTc]-d,l-HMPAO technique with brain dedicated high resolution single photon emission computer tomography (SPECT) in 14 consecutive patients with amyotrophic lateral sclerosis (ALS), median age 62 years (45-77). Global CBF, expressed in % relative to the ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Waldemar G,Vorstrup S,Jensen TS,Johnsen A,Boysen G

    更新日期:1992-01-01 00:00:00

  • Dystrophin characterization in BMD patients: correlation of abnormal protein with clinical phenotype.

    abstract::We have investigated protein expression and genotype in 59 Becker muscular dystrophy (BMD) patients. The aim was to identify possible causes of the marked variability in phenotype in patients with similar deletions/mutations. The patients were examined neurologically and functionally and underwent Manual Muscle Testin...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章


    authors: Morandi L,Mora M,Confalonieri V,Barresi R,Di Blasi C,Brugnoni R,Bernasconi P,Mantegazza R,Dworzak F,Antozzi C

    更新日期:1995-10-01 00:00:00

  • Systemic thrombolytic therapy in acute ischemic stroke--new experiences in spreading network of stroke units in Croatia.

    abstract:BACKGROUND:The aims of this paper are: 1) to present the data of systemic thrombolysis for ischemic stroke in five Croatian centers from July 2008 till January 2010; 2) to compare the results between centers and; 3) to compare data with previously published results from 2006 to 2008 period from our center, and with the...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Matijević V,Poljaković Z,Malojčić B,Mišmaš A,Bazina A,Boban M,Bilić I,Radanović B,Glavor KD,Kiđemet-Piskač S,Habek M

    更新日期:2012-03-15 00:00:00

  • The blood-brain barrier in rats fed on diets high or low in saturated/unsaturated fat ratio.

    abstract::The product of the permeability x vascular surface rate area (PA) of the blood-brain barrier to [14C]sucrose has been measured in rats raised on synthetic diets in which the saturated/unsaturated fat constitution was controlled at high or low levels. Gas-liquid chromatography demonstrated marked differences in brain f...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Phillips SC,Cragg BG,Sinclair AJ

    更新日期:1982-05-01 00:00:00

  • Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury.

    abstract::Thromboxane-prostacyclin imbalance may be an important determinant of platelet-vessel wall interactions that are vital in circulatory homeostasis. In experimental spinal cord injury, the vascular damage contributes substantially to the process of progressive secondary injury culminating in post-traumatic myelopathy. I...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hsu CY,Halushka PV,Spicer KM,Hogan EL,Martin HF

    更新日期:1988-01-01 00:00:00

  • Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline.

    abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. METHODS:35 ALS patients [23 patients presenting with limb...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Morimoto N,Kurata T,Sato K,Ikeda Y,Sato S,Abe K

    更新日期:2012-08-15 00:00:00

  • High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study.

    abstract::High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are ver...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Assaf Y,Mayzel-Oreg O,Gigi A,Ben-Bashat D,Mordohovitch M,Verchovsky R,Reider-Groswasser II,Hendler T,Graif M,Cohen Y,Korczyn AD

    更新日期:2002-11-15 00:00:00

  • Cytotoxic T cells against a peptide of Yo protein in patients with paraneoplastic cerebellar degeneration and anti-Yo antibody.

    abstract::Anti-Yo antibodies are present in the sera and cerebrospinal fluid of some patients with paraneoplastic cerebellar degeneration (PCD), but there is no evidence that the presence of anti-Yo antibodies causes the Purkinje cell loss seen in PCD patients. We examined the level of cytotoxic T lymphocyte (CTL) activity agai...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Tanaka M,Tanaka K,Tokiguchi S,Shinozawa K,Tsuji S

    更新日期:1999-09-15 00:00:00

  • Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum. Electron-microscopic observations.

    abstract::Under electrophysiological control, a focal demyelinating lesion can be produced in the corpus callosum of the rabbit by slow pressure injection of a 1% solution of lysophosphatidyl choline (LPC). Light- and electron-microscopic examination of the LPC demyelinated corpus callosum indicates that many axons remain struc...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Foster RE,Kocsis JD,Malenka RC,Waxman SG

    更新日期:1980-11-01 00:00:00

  • Yes/yes head tremor without appendicular tremor after bilateral cerebellar infarction.

    abstract::We report a 67-year-old man who developed yes/yes head tremor without appendicular tremor six weeks after right occipital and bilateral cerebellar infarction. The tremor was resting-postural. Its activity increased with excitement, decreased either after ethanol, lateroflexion or rest and stopped at sleep. Four-vessel...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Finsterer J,Muellbacher W,Mamoli B

    更新日期:1996-08-01 00:00:00

  • Respiration during sleep in Huntington's chorea.

    abstract::In view of recent reports on lower brainstem dysfunction in Huntington's chorea, we studied respiration during sleep in 12 patients with Huntington's chorea (HC) and in controls. There were no statistically significant differences between patients and controls with respect to apnea periods, respiratory frequency and t...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bollen EL,Den Heijer JC,Ponsioen C,Kramer C,Van der Velde EA,Van Dijk JG,Roos RA,Kamphuisen HA,Buruma OJ

    更新日期:1988-03-01 00:00:00

  • Acute thyrotoxic neuropathy--Basedow's paraplegia revisited.

    abstract::A forty seven year old woman with previously undetected goitre, developed thyroid storm in the immediate postoperative period. Forty eight hours after undergoing nephrolithotomy for renal calculus, she was noted to have flaccid areflexic quadriparesis, most marked in the lower limbs. Electrophysiologic studies reveale...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Pandit L,Shankar SK,Gayathri N,Pandit A

    更新日期:1998-03-05 00:00:00

  • Quality of life and psychological impact in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization.

    abstract:OBJECTIVES:Surgical treatment for adult hemorrhagic moyamoya disease (MMD) remains controversial. A large proportion of Chinese adult patients with hemorrhagic MMD still choose conservative treatment. In this study, we investigated to assess psychological function and quality of life (QoL) in adult patients with hemorr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Su SH,Hai J,Zhang L,Wu YF,Yu F

    更新日期:2013-05-15 00:00:00

  • Aberrant androgen action and increased size of tandem CAG repeat in androgen receptor gene in X-linked recessive bulbospinal neuronopathy.

    abstract::Plasma levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) after 3 or 6 days of administration of the synthetic androgenic hormone fluoxymesterone (10 mg/day) were measured in 26 patients with X-linked recessive bulbospinal neuronopathy (X-BSNP) and 22 age-matched male controls. The...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Sobue G,Doyu M,Morishima T,Mukai E,Yasuda T,Kachi T,Mitsuma T

    更新日期:1994-02-01 00:00:00

  • Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia.

    abstract::The relationship between dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) has been insufficiently described, and it is still problematic. Twenty-nine cases of DLB and 10 cases of PDD were investigated in the present study. DLB cases disclosed a significantly older disease onset and shorter d...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Horimoto Y,Matsumoto M,Nakazawa H,Yuasa H,Morishita M,Akatsu H,Ikari H,Yamamoto T,Kosaka K

    更新日期:2003-12-15 00:00:00

  • Cognitive fatigue in multiple sclerosis: findings from a two-wave screening project.

    abstract:BACKGROUND:Multiple sclerosis (MS) patients commonly suffer from fatigue and define it as one of their most disabling symptom profoundly disrupting their lives. However, the relationship of fatigue to cognitive functions and its impact on quality of life have not been widely studied. AIM:To define (1) "cognitive fatig...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Barak Y,Achiron A

    更新日期:2006-06-15 00:00:00

  • A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia.

    abstract::We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM lambda monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblo...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kira J,Inuzuka T,Hozumi I,Wada H,Tanaka K,Gondo H,Sato S,Tsuji S,Kobayashi T

    更新日期:1997-05-01 00:00:00

  • N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease.

    abstract::The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptor that is involved in synaptic mechanisms of learning and memory, and mediates excitotoxic neuronal injury. In this study, we tested the hypothesis that NMDA receptor subunit gene expression is altered in Alzheimer's disease (AD), esp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bi H,Sze CI

    更新日期:2002-08-15 00:00:00

  • Axonal damage in multiple sclerosis plaques: a combined magnetic resonance imaging and 1H-magnetic resonance spectroscopy study.

    abstract::The purpose of this study was to compare magnetic resonance imaging (MRI) features and proton MR spectroscopy (1H-MRS) patterns of multiple sclerosis (MS) plaques in order to define the metabolic substrate in different lesion subtypes. Combined MRI and single-voxel 1H-MRS investigation was performed in 54 MS patients ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Simone IL,Tortorella C,Federico F,Liguori M,Lucivero V,Giannini P,Carrara D,Bellacosa A,Livrea P

    更新日期:2001-01-01 00:00:00

  • Polymorphic markers in MHC class II/III region: a study on Italian patients with myasthenia gravis.

    abstract::With an Italian case series of 81 Italian patients and 130 controls, we analysed associations between myasthenia gravis (MG) and genetic polymorphisms in the MHC class II/III region. Increases in the frequency of the TNF-B*1, C4A*Q0, C4B*1, DRB1*03 supratype, which is likely part of the 8.1 ancestral haplotype, were m...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Franciotta D,Cuccia M,Dondi E,Piccolo G,Cosi V

    更新日期:2001-09-15 00:00:00

  • Lessons from randomised direct comparative trials.

    abstract::For over a decade, four immunomodulatory therapies have been available for the treatment of relapsing remitting multiple sclerosis. However, few direct comparative data were available to facilitate the choice of treatment. This choice has been influenced by the perception that interferon-beta preparations have greater...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Achiron A,Fredrikson S

    更新日期:2009-02-01 00:00:00

  • Clinical comparison between AVED patients with 744 del A mutation and Friedreich ataxia with GAA expansion in 15 Moroccan families.

    abstract::Fifteen Moroccan families with a phenotype resembling Friedreich Ataxia (FA) were studied. Seven families (13 patients) had the 744 del A mutation in the alpha-tocopherol transfer protein (alpha-TTP) gene, characteristic of ataxia with vitamin E deficiency (AVED). The other eight families (16 patients) had GAA expansi...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Benomar A,Yahyaoui M,Meggouh F,Bouhouche A,Boutchich M,Bouslam N,Zaim A,Schmitt M,Belaidi H,Ouazzani R,Chkili T,Koenig M

    更新日期:2002-06-15 00:00:00

  • Can amyotrophic lateral sclerosis patients with respiratory insufficiency exercise?

    abstract::The authors have shown in a recent paper that survival with amyotrophic lateral sclerosis (ALS) can be increased by the use of non-invasive methods of assisted ventilation (Bipap). However, the progression of muscle weakness was not affected and the quality of life was not positively enhanced. In ALS, reduced physical...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章


    authors: Pinto AC,Alves M,Nogueira A,Evangelista T,Carvalho J,Coelho A,de Carvalho M,Sales-Luís ML

    更新日期:1999-10-31 00:00:00

  • Modulation of alertness by sustained cognitive demand in MS as surrogate measure of fatigue and fatigability.

    abstract:OBJECTIVE:This study used reaction time (RT) as an objective marker of cognitive fatigue and fatigability in patients with multiple sclerosis (MS). METHOD:RT was measured in fifteen healthy controls and in thirty MS patients with cognitive fatigue identified with the Fatigue Scale for Motor and Cognitive Function (FSM...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Neumann M,Sterr A,Claros-Salinas D,Gütler R,Ulrich R,Dettmers C

    更新日期:2014-05-15 00:00:00

  • A family with adult spinal and bulbar muscular atrophy, X-linked inheritance and associated testicular failure.

    abstract::A family with adult spinal and bulbar muscular atrophy with X-linked recessive inheritance (Kennedy's disease) is described. Affected members presented at age 20 with muscle cramps followed insidiously by gynaecomastia, partial loss of secondary sexual traits, loss of libido and inability to maintain an erection. Thre...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Arbizu T,Santamaría J,Gomez JM,Quílez A,Serra JP

    更新日期:1983-06-01 00:00:00

  • Roentgenmorphological aspects of muscular pseudohypertrophy.

    abstract::Using special soft tissue X-ray investigations the authors have found that the increase in volume of the calf musculature in progressive muscular dystrophy does not seem to be in complete accordance with the criteria of pseudohypertrophy. It has been demonstrated that this structural alteration of the musculature does...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Pálvölgyi R,Gallai M

    更新日期:1979-09-01 00:00:00

  • Cerebrospinal fluid and neuropathological study in Devic's syndrome. Evidence of intrathecal immune activation.

    abstract::Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central ne...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Leonardi A,Arata L,Farinelli M,Cocito L,Schenone A,Tabaton M,Mancardi GL

    更新日期:1987-12-01 00:00:00

  • Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation.

    abstract::Cortical excitability to magnetic stimulation was investigated interictally in 10 patients with migraine with aura, 10 with migraine without aura and in 10 healthy volunteers. Thresholds, latencies and amplitudes of the magnetic-evoked potentials (MEPs) were measured from threshold to 100% stimulus intensity in 10% st...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: van der Kamp W,Maassen VanDenBrink A,Ferrari MD,van Dijk JG

    更新日期:1996-07-01 00:00:00

  • Increased cathepsin B activity in multiple sclerosis brain.

    abstract::Cathepsin B (CB) activity was measured in aqueous extracts of frozen autopsy specimens of centrum semiovale from three MS patients, five control patients with other neurological diseases, and five normal individuals. Mean activity was significantly increased in the MS tissue compared with controls. The mean activity i...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bever CT Jr,Garver DW

    更新日期:1995-07-01 00:00:00

  • Myositis caused by Borrelia burgdorferi: report of four cases.

    abstract::Myositis was proven histopathologically in 4 patients (age range 36-66 years) who suffered from early or late stages of Borrelia burgdorferi infection. Muscle weakness was present in 3 patients, 1 complaining of additional myalgias. One man came to medical attention because of skin discoloration and swelling of one le...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Reimers CD,Pongratz DE,Neubert U,Pilz A,Hübner G,Naegele M,Wilske B,Duray PH,de Koning J

    更新日期:1989-06-01 00:00:00