Corticosteroids treatment.

Abstract:

:Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of clinical attacks. Chronic administrations of Cs significantly diminish the formation of T1 hypointense lesions and the progression of brain atrophy. As for patients with secondary progressive MS treatment with Cs delays the time to onset of sustained disability. Finally the association between methylprednisolone and interferon beta (IFNbeta) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNbeta in patients with RRMS.

journal_name

J Neurol Sci

authors

Pozzilli C,Marinelli F,Romano S,Bagnato F

doi

10.1016/j.jns.2004.04.019

subject

Has Abstract

pub_date

2004-08-15 00:00:00

pages

47-51

issue

1

eissn

0022-510X

issn

1878-5883

pii

S0022510X04001194

journal_volume

223

pub_type

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