[Nitrergic reactivity in endothelial cells of human uveal blood vessels].

Abstract:

BACKGROUND:We investigated the presence of Nicotinamid-adenin-dinucleotid-phosphat (NADPH)-diaphorase activity in endothelial cells of the human uveal vessels, using a histochemical procedure which presumably localizes the reaction product nitric oxide. MATERIAL AND METHODS:11 donor eyes destined for corneal transplantation (male: 6; female: 5; age: 56 +/- 8 years) were used within 14 +/- 7 h postmorten. After removal of the cornea and retinal pigment epithelium, flat mounts of the choroid were made. Serial sections, 12-16 microns in thickness were cut from the ciliary body and iris using a cryomicrotome. Sections mounted on chromalaun-gelatine-coated glass slides, treated according the standard NADPH-diaphorase reaction and finally mounted in Kayser's glycerol-gelatine prior to examination in the light microscope. RESULTS:Human choroidal vascular endothelial cells revealed positive NADPH-diaphorase activity, which was detected by the presence of punctate blue staining in the cytoplasm. No significant difference in distribution pattern or area density was seen amongst small and large vessels in either choroid, ciliary body or iris. Ganglion cells in the choroid and ciliary body also exhibited NADPH-diaphorase reactivity. CONCLUSION:The presence of NADPH-diaphorase reactivity in vascular endothelial and ganglion cells of the human choroid suggests a possible nitrergic relaxation mechanism in human uveal vasculature.

journal_name

Klin Monbl Augenheilkd

authors

Bergua A

doi

10.1055/s-2008-1035414

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

115-21

issue

2

eissn

0023-2165

issn

1439-3999

journal_volume

206

pub_type

杂志文章
  • [Trepanation with scleral flap (Elliot-Fronimopoulos) in acute narrow-angle glaucoma (author's transl)].

    abstract::120 eyes with acute closed angle glaucoma were operated by goniotrepanation (Elliot-Fronimopoulos). The follow-up controls showed excellent results. Especially the quick restoration of the anterior chamber and the increase in its depth must be emphasized. There are very rare complications and the resulting eye pressur...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Doden W,Hosch W

    更新日期:1976-12-01 00:00:00

  • [Congenital hypoplasia of the optic nerve (author's transl)].

    abstract::The authors investigated 7 children with developmental anomalies of the optic disc. In all cases a typical pattern of hypoplasia was observed. In all patients was found a very marked impairment of visual acuity or even blindness of the affected eye with most frequently squint and nystagmus. Besides ophthalmological in...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Krzystkowa K,Mirkiewicz-Sieradzka B,Bryk E

    更新日期:1975-08-01 00:00:00

  • [Botulinum Toxin - New Developments in Ophthalmology].

    abstract::Botulinum toxin is recognised as the gold standard for the treatment of essential blepharospasm and hemifacial spasm, which is similar in effect in synkinesis after facial nerve palsy. The injection intervals can be adjusted according to the patients' needs and be shortened for up to six weeks in cases of eyelid cramp...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0042-122339

    authors: Wabbels B

    更新日期:2018-06-01 00:00:00

  • [History of the Berlin Ophthalmology Society].

    abstract::To mark the congress of the Berlin Ophthalmological Society in December 1989, the authors review the development of ophthalmology in Berlin and in particular the history of this ophthalmological society. The review was prompted by the political changes which began in October 1989, enabling ophthalmologists from the ea...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 历史文章,杂志文章

    doi:10.1055/s-2008-1045970

    authors: Goder GJ,Meinel U

    更新日期:1991-04-01 00:00:00

  • [Choroidal neovascularisation in type II membranoproliferative glomerulonephritis, photodynamic therapy as a treatment option--a case report].

    abstract:BACKGROUND:Photodynamic therapy (PDT) is an established treatment in predominantly classic choroidal neovascularisation (CNV) in exudative age-related macular degeneration (AMD). Membranoproliferative glomerulonephritis (MPGN) type II leads to AMD-similar changes ("pseudo-AMD") of the fundus with CNV as a late complica...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2003-40937

    authors: Hassenstein A,Richard G

    更新日期:2003-07-01 00:00:00

  • [Bilateral vascular papillitis following ergotamin medication (author's transl)].

    abstract::A 36-years aged woman suffering from migraine used Ergosanol special-suppositories. An edema of the retina with star figure appeared in both eyes with only a few months distance. After putting away that drug visual acuity restituted completely in spite of a partial neuritic atrophy of the optic nerve in the first suff...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Wollensak J,Grajewski O

    更新日期:1978-11-01 00:00:00

  • [Further clinical studies on chorioiditis geographica].

    abstract::We present two further cases of choroiditis geographica. One of them we were able to follow up for two years. This allowed us to observe from the beginning the eye which was not at first involved. Weeks before the first lesions were visible, alterations of the EOG appeared. In the other case both eyes were already inv...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Pham Duy T,Miszalok V

    更新日期:1984-10-01 00:00:00

  • [Cataract surgery with implantation of toric silicone lenses for severe astigmatism after keratoplasty].

    abstract:BACKGROUND:The treatment of high astigmatism after keratoplasty is often not possible with glasses or refractive corneal surgery, particularly in patients with anisometropia and contact lens incompatibility. METHODS:In 3 patients with cataract and high astigmatism after penetrating keratoplasty, phacoemulsification wa...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2004-813167

    authors: Buchwald HJ,Lang GK

    更新日期:2004-06-01 00:00:00

  • [Prognostic relevance of histopathologic parameters in malignant melanoma of the choroid using the pTNM classification].

    abstract::On the basis of data collected over a period of 22 years from 376 patients enucleated at the Eye Clinic of Karl Marx University, Leipzig because of malignant choroidal melanoma, the prognostic significance and reliability of various histopathological characteristics was investigated. The most significant characteristi...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050116

    authors: Göllnitz R,Lommatzsch PK

    更新日期:1988-04-01 00:00:00

  • [Oxidative stress at the retinal pigment epithelium - experimental implications for protection].

    abstract::Oxidative stress at the retinal pigment epithelium (RPE) is involved in the pathophysiology of age-related macula degeneration (ARMD). Observations on a clinical or laboratory level have revealed that supplementation of antioxidative scavengers failed in many cases. A potential therapeutic target is the cellular signa...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1027600

    authors: Zeitz O,Berna-Thill M,Bartsch U,Strauss O,Richard G

    更新日期:2009-01-01 00:00:00

  • [Hemicentral retinal artery occlusion due to oral contraceptives].

    abstract:BACKGROUND:Low-dose oral contraceptives can still cause thromboembolic disorders with serious neurologic or ocular disabilities. PATIENT:A 22-year-old woman having used oral contraceptives for several months noticed sudden painless visual loss in her left eye. One tablet of her contraceptive contained ethinylestradiol...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1273197

    authors: Schmidt D,Kramer-Zucker A

    更新日期:2011-08-01 00:00:00

  • [Pseudoexfoliation syndrome].

    abstract::The Frequency of the Pseudoexfoliation-Syndrom (= PES) was investigated about two months in a prospective study of 1069 patients in the university eye hospital of Zurich. 7.35% of these patients had a PES with or without glaucoma. Among the clinic patients there were 9.9% and among the policlinic patients 6.26%. All o...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045974

    authors: Esmail F

    更新日期:1991-05-01 00:00:00

  • [Changes in the sensitivity of the cornea in patients with intracerebral tumors. Studies of patients with meningioma of the cranial base and neurinoma of the trigeminal nerve and the vestibulocochlear nerve using the Draeger esthesiometer].

    abstract::The center of the cornea was measured preoperatively in 29 patients suffering from intracranial tumors (acoustic neuroma, trigeminus neuroma, basal meningioma). These measurements were made with the Draeger electronic-optical esthesiometer; the results were supplemented by an analysis of tumor diameters determined by ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050269

    authors: Heller H,Koniszewski G

    更新日期:1988-10-01 00:00:00

  • [The effect of levobunolol eyedrops on trabecular outflow of aqueous humor in chronic simple glaucoma].

    abstract::The present paper reports a double-blind, cross-over, randomized study in which 31 patients (62 eyes) suffering from open-angle glaucoma were included. These patients were treated for one year with 0.5% levobunolol and 0.5% timolol ophthalmic solutions and followed up. Tonographic examinations of outflow facility show...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Călugăru M

    更新日期:1989-03-01 00:00:00

  • [The effect of natural and artificial light via the eye on the hormonal and metabolic balance of man (author's transl)].

    abstract::Examinations of hormone levels in blind persons compared with almost blind and people with normal vision and hormone evaluation with increased artificial light exposure show a definite stimulating effect of light on the human hormonal balance. The effect of light is mediated by an intact perception of light by the eye...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Hollwich F,Dieckhues B,Schrameyer B

    更新日期:1977-07-01 00:00:00

  • [Spot-like to reticular pigment displacement in a patient with pseudoxanthoma elasticum (Grönblad-Strandberg syndrome)].

    abstract::The authors report a rare observation of leopard spot-like and reticular pigmentary patterns in a patient with pseudoxanthoma elasticum (PXE). Characteristic fundus changes associated with PXE have been described as angioid streaks, subretinal neovascularization membranes, peau d'orange, focal retinal pigment epitheli...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046124

    authors: Zürcher M,Schipper I

    更新日期:1990-01-01 00:00:00

  • [Choroid infiltration in myelodysplastic syndrome].

    abstract:BACKGROUND:Myelodysplastic syndrome is a clonal disease of the hematopoetic system characterized by insufficiency of affected bone marrow cell lines. After long-term course of myelodysplastic syndrome an acceleration towards acute myeloic leukemia is a frequent finding. Involvement of the eye is a well known phenomenon...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034944

    authors: Madjlessi F,Dann K,Althaus C,Sundmacher R,Meckenstock G

    更新日期:1998-07-01 00:00:00

  • [Factors influencing applanation tonometry - a practical approach].

    abstract::Applanation tonometry has been the gold standard in clinical ophthalmology for more than fifty years. The most popular factor is central corneal thickness that is now routinely considered in glaucoma management. However, other individual features of the cornea can also play a key role for the interpretation of the app...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1246037

    authors: Rosentreter A,Neuburger M,Jordan JF,Schild AM,Dietlein TS

    更新日期:2011-02-01 00:00:00

  • [Treatment with azathioprine of peripheral chronic cyclitis with cystoid edema of the macula (author's transl)].

    abstract::Nine patients with peripheral chronic cyclitis and cystic edema of the macula were treated with azathioprine and small doses of corticosteroids. The results were quite good. In fact the inflammatory signs subsided nearly completely, while the cystic edema was still present in 2 cases. Besides excellent compatibility, ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:

    authors: Charamis I,Skouras I

    更新日期:1977-03-01 00:00:00

  • [Foveal cone dystrophy: diagnostic ranking of the multifocal electroretinogram].

    abstract:BACKGROUND:In case of visual loss without morphologic pathology differentiation between a functional visual loss and a retinal disorder may be difficult. PATIENTS AND METHODS:We report on two women, aged 33 and 44, who were complaining of a progressive visual loss occurring over the past several weeks to months. They ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2002-32633

    authors: Hübsch S,Gräf M

    更新日期:2002-05-01 00:00:00

  • [Minimally invasive lacrimal duct surgery with a multimodal concept for functional lacrimal stenosis].

    abstract:PURPOSE:The aim of this study was to evaluate the long-term success rates of a multimodal concept for treating functional nasolacrimal duct obstruction (FNLDO) consisting of minimally invasive lacrimal duct surgery and additional treatment of the conjunctiva, the puncta or the lids if necessary. METHODS:Clinical outco...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-0034-1383388

    authors: Stemplewitz B,Amin S,Emmerich KH,Gesser-Wendt C,Meyer-Rüsenberg HW

    更新日期:2015-01-01 00:00:00

  • [Epidemiology of blindness in Baden, Germany].

    abstract:BACKGROUND:There is no exact knowledge concerning blinding diseases in Germany. Purpose of this study was to investigate the changes of diseases leading to new blindness in Baden (Southern Germany). METHODS:We evaluated the ophthalmological diseases leading to blindness in Baden from the applications presented to the ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2004-812724

    authors: Rohrschneider K,Greim S

    更新日期:2004-02-01 00:00:00

  • [Eye Drops Instead of Intravitreal Injections? The Dream of Treating Macular Diseases by Topically Administered Drugs].

    abstract::Background The introduction of VEGF inhibitors revolutionized treatment for age-related macular degeneration. However, it requires regular intravitreal (IVT) injections. Hence, replacement of IVT injections by topical, non-invasive eye drop treatment is subject to intensive research. Material and Methods Literature an...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0043-113253

    authors: Zeitz O,Joussen AM

    更新日期:2017-09-01 00:00:00

  • [Circumscribed peripheral (equatorial or pre-equatorial) retinoschisis (author's transl)].

    abstract::Circumscribed areas of retinoschisis along or anterior to the Equator occur mainly in elderly subjects. Diagnosis is based on biomicroscopic criteria. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057704

    authors: Slezak H,Kenyeres P

    更新日期:1980-12-01 00:00:00

  • [Functional and Anatomic Outcomes of Primary and Secondary Internal Limiting Membrane Transplantation in Large and Persistent Macular Holes].

    abstract:BACKGROUND:The gold standard therapy for full-thickness macular holes (FTMH) is vitrectomy (PPV) with peeling of the internal limiting membrane (ILM), gas tamponade of the vitreous cavity and postoperative face-down positioning. Nevertheless, eyes with large macular holes (> 400 µm) and surgical failures remain difficu...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-121032

    authors: Hess JA,Michels S,Becker MD

    更新日期:2018-10-01 00:00:00

  • [Special sound probe for foreign body localisation (author's transl)].

    abstract::A recently developed sound probe (10 MHz and 3 mm diameter) is suitable for sparing preoperative localisation of foreign bodies in perforated eyes; especially mural foreign bodies can be exactly located intraoperatively. Followed scleral incision foreign bodies can be extracted on the optimal route. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Till P

    更新日期:1978-02-01 00:00:00

  • [Bilateral microsporidial keratitis in an HIV-positive patient with AIDS stage infection].

    abstract:INTRODUCTION:Microsporidia are spore-forming, obligate intracellular protozoa. Humans seem to be infected only by 4 genera of microsporidia. Microsporidial keratoconjunctivitis in immunodeficient patients has a characteristic appearance. CASE REPORT:34 year old woman with AIDS complained of bilateral blurred vision. T...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034934

    authors: Kersten A,Althaus C,Seitz HM,Pfahl HG,Sundmacher R

    更新日期:1998-06-01 00:00:00

  • [Corneal endothelial damage in congenital and juvenile glaucoma].

    abstract::Corneal changes are typical for infantile glaucoma. In newborns, Descemet's membrane and the stroma are still soft, and distend when intraocular pressure rises. Cell counts were performed under the reflecting microscope to determine whether the endothelium is affected when corneal diameter increases and changes occur ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050052

    authors: Wenzel M,Krippendorff U,Hunold W,Reim M

    更新日期:1989-12-01 00:00:00

  • [The circulatory disturbance of the optic nerve with special reference to the side distribution and other dispositional factors (author's transl)].

    abstract::We examined 38 patients with disturbed blood supply to the optic nerve. The observations suggest: 1. men are more frequently affected than women. 2. the first attack of apoplexia nervi optici occurs most often in the left eye. 3. diabetes mellitus and most probably arterial hypertension are risk factors. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Bastian GO

    更新日期:1979-01-01 00:00:00

  • [Operation technic and after care in lens injuries].

    abstract::Extensive experimental research proved that the healing of lens capsule wounds can be supported effectively by application of a fibrin tissue adhesive. The result is a circumscribed scar in an otherwise clear lens. The clinical application of the method was successful as well. Preliminary results have been published a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054911

    authors: Buschmann W

    更新日期:1983-10-01 00:00:00