[Bilateral microsporidial keratitis in an HIV-positive patient with AIDS stage infection].

Abstract:

INTRODUCTION:Microsporidia are spore-forming, obligate intracellular protozoa. Humans seem to be infected only by 4 genera of microsporidia. Microsporidial keratoconjunctivitis in immunodeficient patients has a characteristic appearance. CASE REPORT:34 year old woman with AIDS complained of bilateral blurred vision. The visual acuity was 0.6 on both eyes. She had a mild conjunctivitis and disseminate, not very prominent intraepithelial corneal opacities. She was treated with propamidine isethionate 0.1% 5 times daily and artificial tears under presumptive diagnosis of microsporidial keratoconjunctivitis. We discontinued this treatment because of no improvement. Within 6 months the visual acuity decreased to 0.05. A conjunctival smear was positive for microsporidia. Local Fumagillin-eye-drops 0.07 mg/ml 7 times daily were given. Within 2 weeks an impressively improvement was seen. Because of an persisting diarrhea 400 mg Albendazol twice daily was added orally without success. DISCUSSION:The biomicroscopically changes of microsporidial keratoconjunctivitis are characteristical and lead to the clinical diagnosis. Fumagillin is in vitro and clinically a potent antimicrosporidian agent with an extremely broad therapeutic range.

journal_name

Klin Monbl Augenheilkd

authors

Kersten A,Althaus C,Seitz HM,Pfahl HG,Sundmacher R

doi

10.1055/s-2008-1034934

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

476-9

issue

6

eissn

0023-2165

issn

1439-3999

journal_volume

212

pub_type

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