Abstract:
:On the basis of data collected over a period of 22 years from 376 patients enucleated at the Eye Clinic of Karl Marx University, Leipzig because of malignant choroidal melanoma, the prognostic significance and reliability of various histopathological characteristics was investigated. The most significant characteristic proved to be the cell type, followed by the degree of pigmentation, the nature and degree of infiltration of the sclera, and tumor size. The relationship of these parameters to the survival rate was shown to be statistically significant by the mortality tabulation method, contingency tabulation method and rank correlation (Spearman). Furthermore, various correlations between the observed variables were ascertained. This statistical analysis shows that the mitosis has no significant bearing on the prognosis. The five-year metastasis rate was 32.8% and the ten-year rate 40.3%. The metastasis peak of 10.4% occurs in the second postoperative year. After the fifth year the annual mortality rate falls to less than 2% and after the seventh year to less than 1%. The data also indicate that even small, Stage I melanomas metastasize if they are not composed purely of spindle cells. With such tumors the peak metastasis rate shifts to the fourth postoperative year.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Göllnitz R,Lommatzsch PKdoi
10.1055/s-2008-1050116subject
Has Abstractpub_date
1988-04-01 00:00:00pages
296-301issue
4eissn
0023-2165issn
1439-3999journal_volume
192pub_type
杂志文章abstract:BACKGROUND:Heavier than water tamponades offer the possibility to support the inferior part of the fundus after retinal detachment. The aim of this study was to evaluate the anatomic and functional outcome of complicated retinal detachment treated with vitreous surgery and heavy silicone oil (HSO) tamponade. Surgery wa...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0028-1109685
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Can the capsulotomy with small radial incisions compared to the continuous curvilinear capsulorhexis with perfect IOL centration still be recommended? This problem should be clarified under standard conditions. METHOD:On 100 patients both procedures were applied alternating with corneoscleral incision, phac...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035520
更新日期:1994-04-01 00:00:00
abstract::Using the CANON CG 6 60 Z wide-angle fundus camera, fluorescein angiographic examinations of the fundus periphery were performed on 90 diabetic patients presenting with exudative diabetic maculopathy. The peripheral angiogram demonstrates that perimacular hyperpermeability - the main cause of diabetic maculopathy - is...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050901
更新日期:1985-03-01 00:00:00
abstract::Following a brief survey of the subjects covered in this paper the author discusses the problem of lacrimal gland tumefactions. These can be divided into five groups: malignant lymphoma and leukemias, proliferative reactions of the lymphatic tissues, dacryoadenitis, secondary and metastatic tumors, and finally miscell...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050952
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Cat scratch disease (CSD) is a common infectious disease, however its association with a disciforme keratitis is to our knowledge a previously unreported ocular complication. PATIENT:A 65-year old female was treated unsuccessfully with topical antibiotics, acyclovir and corticosteroids for several weeks bec...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2000-10372
更新日期:2000-11-01 00:00:00
abstract::The action of some drugs on the eye may lead to the occurrence of unforeseen ocular and extraocular reactions. Vincaleukoblastin (Velbe) provokes serious corneal lesions with a healing time of two weeks and a half. The local application of Neo-Synephrine eye drops (10%) and Mydrial-Atropine ointment may lead in the ca...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:The intravitreal injection of an anti-VEGF compound is the current standard of care in neovascular AMD. The response to this therapy varies greatly. To date it was not possible to determine clear predictive factors in regard to therapy response, thus making it difficult when counselling patients regarding th...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1299250
更新日期:2012-04-01 00:00:00
abstract::By means of torsional shift operation, or "rotatory Kestenbaum procedure" - in which both ocular bulbs are rotated to the side to which the head is inclined - head malpostures can be eliminated or alleviated in three out of four cases. This applies both to the smaller group of patients with true nystagmus compensation...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050307
更新日期:1988-12-01 00:00:00
abstract::A study is presented of a case of serous detachment of the mucula secondary to congenital pit of the optic disc. We observed during fluorescein angiography a late leakage of dye at the temporal margin of the disc. A lasercoagulation of this lesion gave a favourable result. All these findings support Gass' explanation ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Earlier studies in monkeys have shown that latanoprost 0.005% lowers the IOP by improving the uveoscleral Outflow. We wanted to know if this is also the case in the human eye. PATIENTS AND METHODS:We used our new aqueous humor outflow test with 2-nitrophenyl-acetate in 9 healthy human volunteers, mean age 3...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034877
更新日期:1998-05-01 00:00:00
abstract::The present paper reports a double-blind, cross-over, randomized study in which 31 patients (62 eyes) suffering from open-angle glaucoma were included. These patients were treated for one year with 0.5% levobunolol and 0.5% timolol ophthalmic solutions and followed up. Tonographic examinations of outflow facility show...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-03-01 00:00:00
abstract::Diabetic macular edema (DME) and proliferative retinopathy are common causes for blindness in middle-aged patients. The gold standard for treatment has been laser coagulation. Limitations of this therapy are refractive DME, ischaemic diabetic maculopathy and complications after laser application. The need for a non-de...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1245718
更新日期:2010-09-01 00:00:00
abstract::3 cases of cyclical convergent strabismus (48 hour rhythm) were investigated. In contrast to intermittant strabismus, cyclical strabismus is not fatigue dependant. An alteration in the rhythm of the cyclical esotropia was produced by wearing prisms, red glasses or occlusion for several days. This observation indicates...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract:PURPOSE:To evaluate the effect of soft contact lenses with different lens power on the measured value of the intraocular pressure with non-contact pneumotonometry. METHODS:120 eyes (80 healthy volunteers: 50 women, 30 men, aged 22 to 61 years) were included in this study. Intraocular pressure was measured with a pneum...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2003-812564
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:POEMS occurs only in about 1% of plasmocytoma cases, but in more than 50% of the rare osteosclerotic subtypes and plasma cell dyscrasias. The estimated frequency is 20 cases per year in Germany. Swelling of the optic disks is an early sign of the syndrome. CASE REPORT:An osteosclerotic plasmocytoma type IgA...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1034671
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Lattice corneal dystrophy type I is one of the frequent forms of stromal dystrophies following autosomal dominant inheritance. The beta-IG-h3 gene encoding keratoepithelin on the long arm of chromosome 5 has recently been described as disease gene for lattice corneal dystrophy type I as well as for three oth...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034852
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Diagnosis of syphilis is often very difficult due to the absence of typical organ manifestation. In addition syphilis has the ability to imitate any ocular inflammation. This may result in misdiagnosis and delay of appropriate antimicrobial therapy. Up to now the first choice therapy is penicillin. CASE REP...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-17141
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:The aim of this study was the evaluation of new algorithms to measure diameter of segments of retinal branch vessels offline in local dependence and independent by observer. Methods 360 flashed fundus images (camera FF 450 ZEISS Germany, Visualis IMEDOS GmbH Weimar/Germany) of 12 eyes of healthy volunteers (10 ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-17640
更新日期:2001-09-01 00:00:00
abstract::The causes of hypo- and hyperchromic heterochromia were analysed in 94 patients. The hypochromic forms were the commonest, especially the Fuchs-Herrenschwandt heterochromia, and heterochromia simplex. Also after degenerative diseases and accidents appears almost exclusively hypochromic heterochromia. Causes of hyperch...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:Double-blind, randomised, placebo-controlled and multicentre studies have proven an increase in visual acuity in one-third of the patients receiving Ranibizumab (0.5 mg) injections, who suffer from exsudative AMD. The purpose of this study was to evaluate the early effects of intravitreal Ranibizumab therapy...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0029-1245131
更新日期:2011-02-01 00:00:00
abstract::A case of Zinsser-Engman-Cole syndrome (Dyskeratosis congenita) with severe fundus changes is reported. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::Clinical and morphological studies were undertaken to characterize a case of congenital glaucoma combined with an ocular-dental-digital dysplasia in a two year old patient. Light and electromicroscopic investigations of a surgically removed trabecular specimen were carried out. A trabeculotomy had been performed at th...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Patients suffering from various retinal diseases benefit from therapies directed against the vascular endothelial growth factor (VEGF). Aflibercept (Eylea) is another VEGF-binding protein available for intravitreal injection, in addition to the antibody bevacizumab (Avastin) and the F(ab) fragment ranibizumab (Lucenti...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1383142
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate retrospectively the clinical outcome of retinal photocoagulation of age-related juxtapapillary choroidal neovascularisation (CNV) with macular oedema. Juxtapapillary CNV represents a rare form of extrafoveal CNV in age-related macular degeneration (AMD). PATIENTS AND ME...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1273430
更新日期:2011-11-01 00:00:00
abstract::In 82 cataract patients the power of the pseudophakos to be implanted was determined. Axial length and anterior chamber depth were measured by ultrasound. The results of keratometry and the echographic data were used for lens power calculation. For the accuracy of prediction the estimated post-operative anterior chamb...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055264
更新日期:1982-11-01 00:00:00
abstract::A brother and a sister with DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, deafness, etc.) are described. The 15-year-old girl was suffering from severe optic atrophy, severe sensorineural hearing loss but only slight diabetic retinopathy. The 16-year-old boy presented with symptoms which were...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054578
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:In the year 2000, the photodynamic therapy (PDT) was introduced as a new option for the treatment of exudative choroidal neovascularisation (CNV). Since this kind of therapy required the health insurance company's consent, the waiting period for the first therapy varied considerably. MATERIALS AND METHODS:B...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-962955
更新日期:2007-02-01 00:00:00
abstract::Even in patients with consecutive strabismus who had a partial or total tenotomy 10 to 50 years ago, reoperation is worthwhile. In 73% of the author's cases the squint angle was reduced to between -5% degrees and +5 degrees postoperatively; adduction or abduction were improved or normalized in 66%, convergence in 20%....
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050239
更新日期:1988-08-01 00:00:00
abstract::120 eyes with acute closed angle glaucoma were operated by goniotrepanation (Elliot-Fronimopoulos). The follow-up controls showed excellent results. Especially the quick restoration of the anterior chamber and the increase in its depth must be emphasized. There are very rare complications and the resulting eye pressur...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract::No significant differences could be determined postoperatively between trabeculectomy and goniotrepanation. However, cases of flattened anterior chambers and choroidal detachments were less frequent after goniotrepanation than after trabeculectomy. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057716
更新日期:1980-12-01 00:00:00