Abstract:
INTRODUCTION:Necrotizing enterocolitis (NEC) is the most commonly acquired neonatal intraabdominal emergency and causes significant morbidity and mortality. A proposed strategy for the prevention of NEC in preterm infants is the administration of oral probiotics. The objective of the study is to analyze the efficacy and safety of oral probiotics in preterm infants to try to answer the following question: oral probiotics in Neonatology, yes or no?. METHODOLOGY:A scheme of work based on the five standard steps of medicine based on scientific evidence (EBM) was used: 1) question, 2) search, 3) valuation, 4) applicability and 5) adequacy. Electronic searches were performed on international (Tripdatabase, Cochrane Collaboration, National Guideline Clearinghouse, GuiaSalud, INHATA, Medline, SciELO) and national (Índice Médico Español, Índice Bibliográfico Español en Ciencias de la Salud y MEDES) database. RESULTS:we selected 8 systematic reviews (SR) that answered our clinical question, published between 2007 and 2012, and which included the best available information (randomised clinical trials). Risk of death was significantly reduced in probiotic groups in all SR, with relative risk (RR) 0,40 to 0,56. Risk of NEC was significantly reduced in probiotic groups in all SR, with RR 0,32 to 0,36. Risk of sepsis did not differ significantly between groups. CONCLUSIONS:The findings of the 8 SR show potential prevention of oral probiotics in mortality and morbidity secondary to NEC. However, they must be interpreted with caution because the beneficial effects of probiotics seem to be strain specific, thus, pooling data from different strains may result in misleading conclusions. We found two groups of investigation in this field ("yes, of course" and "no, be careful") and there is encouraging data which justifies further and definitive clinical trial regarding the efficacy and safety of specific probiotics in circumstances of high local incidence of severe NEC. :Introducción. La enterocolitis necrotizante (NEC) es la urgencia abdominal adquirida más frecuente en el recién nacido y ocasiona importante morbi-mortalidad. Una estrategia preventiva es la administración de probióticos orales para la prevención de NEC en prematuros. . El objetivo de este estudio es analizar la eficacia y seguridad de los probióticos orales en prematuros para intentar responder a la pregunta: probióticos orales en Neonatología, ¿sí o no?. Material y métodos. Se planteó un esquema de trabajo en base a los cinco pasos característicos de la Medicina basada en la evidencia o en pruebas científicas (MBE): 1) pregunta, 2) búsqueda, 3) valoración, 4) aplicabilidad y 5) adecuación. Las búsquedas electrónicas se realizaron en bases de datos internacionales (Tripdatabase, Cochrane Collaboration, National Guideline Clearinghouse, GuiaSalud, INHATA, Medline, SciELO) y nacionales (Índice Médico Español, Índice Bibliográfico Español en Ciencias de la Salud y MEDES). Resultados. Se seleccionaron 8 revisiones sistemáticas (RS) que respondían a la pregunta clínica, publicadas entre los años 2007 y 2012, y que incluyen la mejor información disponible (como ensayos clínicos). El riesgo de muerte disminuía significativamente en los grupos de administración de probióticos en todas las RS, con un riesgo relativo (RR) entre 0,40 y 0,56. El riesgo de NEC disminuía significativamente en los grupos de administración de probióticos en todas las RS, con un RR entre 0,32 y 0,36. El riesgo de sepsis no difería significativamente entre grupos. Conclusión. Los hallazgos de las 8 RS muestran, de forma consistente, que los probióticos orales ofrecen una prevención potencial en la morbi-mortalidad secundaria a NEC. Sin embargo, estos datos deben interpretarse con cautela dado que los efectos beneficiosos de los probióticos son específicos de cepa, por lo que, agrupar datos de diferentes cepas puede conllevar a conclusiones erróneas. Encontramos dos grupos de investigación en este campo (“yes, of course” y “no, be careful”) y disponemos de pruebas suficientes que justifican la realización de un ensayo clínico definitivo que analice la eficacia y seguridad de probióticos específicos en circunstancias locales de alta incidencia de NEC grave.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
González de Dios J,González Muñoz Mdoi
10.3305/nutr hosp.v28in06.6901subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2115-23issue
6eissn
0212-1611issn
1699-5198journal_volume
28pub_type
杂志文章,meta分析,评审abstract:INTRODUCTION:beginning of adolescence comprises important physical modifications, which affects growth and changes in body composition, therefore it is important to consider maturation assessment. OBJECTIVE:to develop a non-invasive method to assess maturity status in Venezuelan adolescents from peak height velocity (...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.5.9566
更新日期:2015-11-01 00:00:00
abstract::The purpose of this review is to address methodological issues related to accelerometer-based assessments of physical activity (PA) in older individuals. Special interest is also put on recently updated technology. No definitive evidence exists currently to indicate which are the more valid and reliable accelerometer ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To update the system for nutritional screening. The high prevalence of nutritional unstability that causes the Clinical Undernutrition (CU), especially within the hospitals and assisted residencies, makes it necessary to use screening tools for the constant control of undernutrition to combat it during its de...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2014.29.4.7275
更新日期:2014-01-13 00:00:00
abstract:INTRODUCTION:Gestational diabetes has been associated with obesity later in life. However, reported results have not been consistent and the methods used have shown weakness. OBJECTIVE:To analize prospective and retrospective cohort studies that assess the gestational diabetes effects on adiposity indicators in the of...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2014.29.2.7042
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:Coffee and tea consumption recommendations for a healthy diet have been changing in recent years as it has increased the level of evidence on their benefits has increased. OBJECTIVE:To know the frequency of coffee and tea consumption of in a high cardiovascular risk Mediterranean population (CVR) and to a...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:A good tool to determine the biotype of growing and developing subjects that has been observed is the somatotype (ST). Objetive: This research study aims to describe the ST tendency in Chilean adolescents along the years. METHODS:The bibliographic review was carried out using data from Medline, ISI Web of...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2015.31.3.8425
更新日期:2014-12-17 00:00:00
abstract:Introduction:Background: the legislation currently regulating the inclusion of Food for Special Medical Purposes (FSMP) among the benefits of the National Health System (SNS) was made approximately 15 years ago. The evolution of the technical characteristics of the FSMP justifies an analysis of the current regulation a...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03082
更新日期:2020-12-16 00:00:00
abstract:OBJECTIVES:Nutritional aspects of breakfast, plasma levels of glucose and beta-hydroxybutyrate, body mass index and academic performance have been studied in urban and rural children (Extremadura, Spain). METHODS:Representative samples of schoolchildren (3 to 12 years old, random cluster-sampling in schools). RESULTS...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract:UNLABELLED:Meal replacement (MR) has been frequently used to substitute one or more meals during the day. However, few randomized long-term studies have assessed its efficacy. OBJECTIVE:To asses meal replacement use and its effectiveness on long-term weight loss (> 1 year) in overweight and obese people with or withou...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.1590/S0212-16112011000600011
更新日期:2011-11-01 00:00:00
abstract::La detección de la desnutrición hospitalaria continúa de plena actualidad en la literatura médica y, a pesar de que desde hace dos décadas dejó de ser un tema novedoso, constituye un elemento recurrente en la bibliografía y motivo de abordajes monográficos en congresos y reuniones científicas. ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.251
更新日期:2016-06-30 00:00:00
abstract::Given the negative effect of malnutrition on the immune function, the possibility must be considered that this also affects the clinical progression of AIDS patients. This study was aimed at assessing the state and nutritional support indicated for patients diagnosed as having AIDS. 114 patients admitted to our hospit...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:UNLABELLED:Morbid obesity is a risk factor for numerous diseases including liver disease with an incidence of hepatic steatosis from 70 to 80%. Although surgical treatment is effective in reducing weight, its effects on the liver have not been established convincingly. We report 2 cases of patients with bariatric surge...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.1.9174
更新日期:2015-07-01 00:00:00
abstract:UNLABELLED:Nutritional management is essential in anorexia nervosa (AN), although nutrient replenishment must be done progressively to prevent the occurrence of re-alimentation syndrome. OBJECTIVE:to compare resting enengy expenditure (REE) by means of indirect calorimetry and by different equations in AN female patie...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract:INTRODUCTION:Epidemiological studies show that during the last two decades childhood obesity has increased dramatically to become, one of the major public health concerns. Dietary habits, lack of physical activity and the degree of obesity rates and worsen over the years making overweight children overweight adults. A...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.1.7785
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Malnutrition in children with cancer is a significant risk factor for negative outcomes, but in the clinical practice setting, it is difficult to pinpoint which factors operate to cause substantial weight loss and malnutrition in a given patient. Appetite-related hormones like ghrelin and leptin are among ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.20960/nh.1221
更新日期:2018-01-19 00:00:00
abstract::Introducción: a escala mundial y nacional se reporta una alta prevalencia de sobrepeso y obesidad en menores de 5 años. La etiología es multifactorial, pero factores ambientales como sedentarismo y el progresivo deterioro de la alimentación promueven el exceso de peso y conllevan a mayor riesgo de enfermedades crónica...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.566
更新日期:2016-09-20 00:00:00
abstract::We have done a clinical study in patients with benign biliary disease and indication for surgery, with the aim of analyzing some parameters of gastric secretion, biliary and pancreatic function, and gastrointestinal hormones in relation to the quantity and quality of the dietary fat (monounsaturated and polyunsaturate...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::The liver is an important organ with specific functions that influence directly on the nutritional and physiological status of every person. At the presence of any illness or injury in this organ, liver cirrhosis is always its final phase. In this pathology, patients present carbohydrate utilization and storage dimini...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2014.29.2.7024
更新日期:2014-02-01 00:00:00
abstract::Given the high numbers of nutritional supplements and enteral diets which are supplied for patients suffering from cystic fibrosis, by the departments of hospital pharmacy, the present study aims to review which are the characteristics of this disease which determine the appearance of malnutrition in these patients. A...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract::Severe metabolic alterations frequently occur in critically ill cancer patients; hypercalcemia, hypocalcemia, hyponatremia, tumor lysis syndrome, metabolic complications of renal failure and lactic acidosis. Cancer patients with metabolic emergencies should be treated in a medical oncology department or an intensive c...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nutr hosp.v28in06.6959
更新日期:2013-11-01 00:00:00
abstract::We report the case of a patient with recurrent severe hypocalcemia, secondary to hypomagnesaemia, and prerenal renal failure, due to ileostomy losses after a colectomy, who needed several admissions to the hospital through more than one year. Finally, he was successfully treated by self-administered subcutaneous magne...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To assess enteral nutrition complications in a prospective cohort of patients admitted to the ICU. MATERIAL AND METHODS:Prospective, multicenter study of patients admitted to the ICU and that received enteral nutrition (EN). Demographical data, main diagnosis, and nutritional and severity indexes were includ...
journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2005-07-01 00:00:00
abstract:GOAL:Once again, the NADYA-SENPE Working Group analysed the registered data of Home Enteral Nutrition (HEN) in our country, during the year 2000. MATERIAL AND METHODS:The data were collected through a closed questionnaire included on our web site (www.nadya-senpe.com). Apart from epidemiological information, the form ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Sugars are sweet-flavored carbohydrates that provide energy to the body. The adult brain uses about 140 g of glucose per day, amount which can represent up to 50 of the total number of carbohydrates consumed. In our country the sugar in food consumption pattern remains constant, while the consumption of soft drinks ha...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.sup4.6794
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:The physical activity and adequate food plays a key role in improving health and the control of diseases. OBJECTIVE:This paper aims at determining the nutritional state through anthropometric measures, socioeconomic level, the most common illnesses and type of physical activity, beyond food consumption an...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to assess the quality of life (QoL), nutritional status, and quantitative food intakes of non-terminal admitted cancer patients receiving oral feeding. As well as to evaluate what kind of relation exists between the quality of life, and the nutritional status and current int...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:The satisfaction's analysis is being used as an instrument to create different sanitary reforms to improve the quality and numerous studies aim to the increase the mother's satisfaction directly related to the maternity care. OBJECTIVES:[corrected] Identify the woman satisfaction's degree about birth atte...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.3.6395
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:There is scarce and inconsistent information about gender-related differences in the hydration of sports persons, as well as about the effects of hydration on performance, especially during indoor sports. OBJECTIVE:To determine the physiological differences between genders during in indoor physical exerci...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,随机对照试验
doi:10.3305/nh.2014.29.3.7017
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:It has been reported that excessive gestational weight gain (GWG) during pregnancy is associated with an increase in adiposity indicators and metabolic disorders of the offspring. OBJECTIVE:The objective of this review, using the Institute of Medicine (IOM) criteria, was to analyze the association of exce...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2015.31.4.8297
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:one of the main extradigestive manifestations of celiac disease is the decrease in bone mineral density (BMD). Bone densitometry performed with DXA is the method of choice for BMD assessment. Indications for its use in celiac children are controversial. OBJECTIVE:analyzing BMD and various clinical-analyti...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.1510
更新日期:2018-06-04 00:00:00