Association of excessive GWG with adiposity indicators and metabolic diseases of their offspring: systematic review.

Abstract:

INTRODUCTION:It has been reported that excessive gestational weight gain (GWG) during pregnancy is associated with an increase in adiposity indicators and metabolic disorders of the offspring. OBJECTIVE:The objective of this review, using the Institute of Medicine (IOM) criteria, was to analyze the association of excessive GWG in prospective studies with the adiposity indicators and metabolic diseases of the offspring, and the association of excessive GWG with adiposity indicators and metabolic disease of the ≥ 15 years offspring. METHODS:An electronic search was conducted in the MEDLINE/PubMed, EMBASE, and CINAHL databases of prospective cohort studies published from January 2004 to September 2014. Selection was restricted to prospective cohort studies where the definition of GWG was used according to the IOM-recommendations; and prospective cohort studies including offspring ≥ 15 years, independent of using the definition for excessive GWG. RESULTS:Nine prospective cohort studies meet the inclusion criteria. Five studies used the IOM-recommendations for assessing GWG, and six studies assessed adiposity or metabolic indicators of their offspring at ≥ 15 years. In seven of the nine studies, excessive GWG was associated with adiposity and metabolic diseases. Due to the limitations found, the evidence of the association was shown to be low. CONCLUSIONS:The results of this review showed, that independently of the criteria used to diagnose excessive GWG, all the included studies, consistently showed an association of excessive GWG with adiposity indicators or other components of metabolic disease early in life, during adolescence or adulthood. However, due to the limitations of the studies the strength of the evidence was low. Better designed studies are warranted to confirm a stronger evidence. :Introducción Se ha reportado que el aumento excesivo de la ganancia de peso gestacional (GPG) durante el embarazo está asociada a un aumento en los indicadores de adiposidad y trastornos metabólicos de su descendencia. Objetivo El objetivo fue analizar la asociación del aumento excesivo de GPG en estudios prospectivos, utilizando los criterios del Instituto de medicina (IOM), con indicadores de adiposidad y enfermedades metabólicas de los descendientes y estudiar la asociación del aumento excesivo de GPG en estudios prospectivos con indicadores de adiposidad y enfermedad metabólica de los descendientes ≥ 15 años. Métodos Se realizó una búsqueda electrónica en las bases de datos MEDLINE/PubMed EMBASE y CINAHL, de estudios prospectivos de cohorte publicados de enero de 2004 a septiembre de 2014. La selección de artículos fue restringida a estudios en los que la definición de GPG siguiera las recomendaciones del IOM; y estudios prospectivos de cohorte incluyendo los descendientes ≥ a 15 años de edad, con diferentes definiciones de GPG, independiente de la definición utilizada. Resultados Nueve estudios prospectivos cumplieron los criterios de inclusión. Cinco estudios utilizaron las recomendaciones del IOM para la evaluación de GPG, y seis estudios evaluaron indicadores de adiposidad o enfermedades metabólicas en los descendientes ≥ 15 años. En siete de los nueve estudios, se observó que a mayor GPG de la madre, de cualquier categoría de peso pre gestacional, mayor adiposidad y prevalencia de otros componentes del síndrome metabólico. Debido a las limitaciones explicadas en el estudio la evidencia de la asociación es baja. Conclusiones Los resultados de esta revisión muestran que independientemente de los criterios utilizados para diagnosticar el aumento de la GPG, todos los estudios muestran consistentemente una asociación entre la GPG y los indicadores de adiposidad u otros componentes del síndrome metabólico en la niñez, durante la adolescencia o la edad adulta. Sin embargo, debido a las limitaciones de los estudios, la fuerza de la evidencia es baja. Son necesarios estudios mejor diseñados para confirmar esta asociación con una mayor fuerza de la evidencia.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Pérez-Morales ME,Bacardi-Gascon M,Jimenez-Cruz A

doi

10.3305/nh.2015.31.4.8297

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1473-80

issue

4

eissn

0212-1611

issn

1699-5198

journal_volume

31

pub_type

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