Translational inhibition by a human cytomegalovirus upstream open reading frame despite inefficient utilization of its AUG codon.

abstract：:Herpes simplex virus 1 (HSV-1) capsids leave the nucleus by a process of envelopment and de-envelopment at the nuclear envelope (NE) that is accompanied by structural alterations of the NE. As capsids translocate across the NE, transient primary enveloped virions form in the perinuclear space. Here, we provide evidenc...

journal_title：Journal of virology

authors： Maric M,Shao J,Ryan RJ,Wong CS,Gonzalez-Alegre P,Roller RJ

更新日期：2011-10-01 00:00:00

abstract：:To assess the possible contribution of host immune responses to the exertion of Fv2-associated resistance to Friend virus (FV)-induced disease development, we inoculated C57BL/6 (B6) mice that lacked various subsets of lymphocytes with FV containing no lactate dehydrogenase-elevating virus. Fv2(r) B6 mice lacking CD4(...

journal_title：Journal of virology

authors： Tsuji-Kawahara S,Kawabata H,Matsukuma H,Kinoshita S,Chikaishi T,Sakamoto M,Kawasaki Y,Miyazawa M

更新日期：2013-12-01 00:00:00

abstract：:One-step growth determinations were performed with five strains of rotavirus in HepG2, a cell line derived from human liver. Three virus strains (SA11-C13, SA11-C14, and RRV) replicated in HepG2 cells and attained yields 10- to 100-fold above input titers. Two virus strains (B223 and SA11-4F) failed to replicate above...

journal_title：Journal of virology

authors： Ramig RF,Galle KL

更新日期：1990-03-01 00:00:00

abstract：:Propagation of the agents responsible for transmissible spongiform encephalopathies (TSEs) in cultured cells has been achieved for only a few cell lines. To establish efficient and versatile models for transmission, we developed neuroblastoma cell lines overexpressing type A mouse prion protein, MoPrP(C)-A, and then t...

journal_title：Journal of virology

authors： Nishida N,Harris DA,Vilette D,Laude H,Frobert Y,Grassi J,Casanova D,Milhavet O,Lehmann S

更新日期：2000-01-01 00:00:00

abstract：:We have used an antisense RNA approach in the analysis of gene function in human cytomegalovirus (HCMV). An astrocytoma cell line (U373-MG) that is permissive for virus replication was permanently transfected with a construct bearing sequence from HCMV UL44 (coding for the major late DNA-binding protein, ppUL44, also ...

journal_title：Journal of virology

authors： Ripalti A,Boccuni MC,Campanini F,Landini MP

更新日期：1995-04-01 00:00:00

abstract：:The deoxyribonucleic acid (DNA) of Escherichia coli B is converted by colicin E2 to products soluble in cold trichloroacetic acid; we show that this DNA degradation (hereafter termed solubilization) is subject to inhibition by infection with bacteriophage T4. At least two modes of inhibition may be differentiated on t...

journal_title：Journal of virology

authors： Swift RL,Wiberg JS

更新日期：1971-09-01 00:00:00

abstract：:The genetic basis for the distinctive capacity of influenza A/WSN/33 (H0N1) virus (WSN virus) to produce plaques on bovine kidney (MDBK) cells was found to be related to virus neuraminidase. Recombinant viruses that derived only the neuraminidase of WSN virus were capable of producing plaques, whereas recombinant viru...

journal_title：Journal of virology

authors： Schulman JL,Palese P

更新日期：1977-10-01 00:00:00

abstract：:The gastric mucosa is an important portal of entry for lymphocytic choriomeningitis virus (LCMV) infections. Within hours after intragastric (i.g.) inoculation, virus appears in the gastric epithelia, then in the mesenteric lymph nodes and spleen, and then in the liver and brain. By 72 h i.g.-inoculated virus is widel...

journal_title：Journal of virology

authors： Yin C,Djavani M,Schenkel AR,Schmidt DS,Pauza CD,Salvato MS

更新日期：1998-11-01 00:00:00

abstract：:Physiological microenvironments such as blood, seminal plasma, mucosal secretions, or lymphatic fluids may influence the biology of the virus-host cell and immune interactions for human immunodeficiency virus type 1 (HIV-1). Relative to media, physiological levels of human plasma were found to enhance the infectivity ...

journal_title：Journal of virology

authors： Wu SC,Spouge JL,Conley SR,Tsai WP,Merges MJ,Nara PL

更新日期：1995-10-01 00:00:00

abstract：:Numerous RNA viruses generate subgenomic mRNAs (sgRNAs) for expression of their 3'-proximal genes. A major step in control of viral gene expression is the regulation of sgRNA synthesis by specific promoter elements. We used barley yellow dwarf virus (BYDV) as a model system to study transcriptional control in a virus ...

journal_title：Journal of virology

authors： Koev G,Miller WA

更新日期：2000-07-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) is divided into three subgroups, A, B, and C, based on sequence divergence at the left end of genomic DNA in which the saimiri transforming protein (STP) resides. Subgroup A and C strains transform primary common marmoset lymphocytes to interleukin-2-independent growth, whereas subgroup B str...

journal_title：Journal of virology

authors： Choi JK,Ishido S,Jung JU

更新日期：2000-09-01 00:00:00

abstract：:Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all viral genes that are efficiently packaged into functional Ad capsids. As a specific application of this finding, we gen...

journal_title：Journal of virology

authors： Lieber A,Steinwaerder DS,Carlson CA,Kay MA

更新日期：1999-11-01 00:00:00

abstract：:Hypervariable region 5 (HVR5) is a hydrophilic, serotypically nonconserved loop of the hexon monomer which extrudes from the adenovirus (Ad) capsid. We have replaced the HVR5 sequence of Ad5 with that of heterologous peptides and studied their effects on virus viability and peptide accessibility. A poliovirus model ep...

journal_title：Journal of virology

authors： Vigne E,Mahfouz I,Dedieu JF,Brie A,Perricaudet M,Yeh P

更新日期：1999-06-01 00:00:00

abstract：:Reovirus serotype 1 Lang can be recovered in high titer from the intestines of neonatal mice up to day 8 after peroral inoculation. By contrast, reovirus serotype 3 Dearing cannot be recovered from intestinal tissue past day 4 after peroral inoculation. This difference between the two reoviruses was mapped by using re...

journal_title：Journal of virology

authors： Bodkin DK,Fields BN

更新日期：1989-03-01 00:00:00

abstract：:Infection of human dermal microvascular endothelial (HMVEC-d) cells and human foreskin fibroblast (HFF) cells in vitro by Kaposi's sarcoma-associated herpesvirus (KSHV) provides an excellent in vitro model system to study viral latency. KSHV infection is characterized by the induction of preexisting host signal cascad...

journal_title：Journal of virology

authors： Sharma-Walia N,Raghu H,Sadagopan S,Sivakumar R,Veettil MV,Naranatt PP,Smith MM,Chandran B

更新日期：2006-07-01 00:00:00

abstract：UNLABELLED:The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tra...

journal_title：Journal of virology

authors： Jiang AP,Jiang JF,Wei JF,Guo MG,Qin Y,Guo QQ,Ma L,Liu BC,Wang X,Veazey RS,Ding YB,Wang JH

更新日期：2015-12-30 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV) is the major cause for Merkel cell carcinoma (MCC), a rare but highly aggressive skin cancer predominantly found in elderly and immunosuppressed patients. The early viral gene products large T-antigen (LT) and small T-antigen (sT) are important for efficient viral DNA replication, and ...

journal_title：Journal of virology

authors： Czech-Sioli M,Siebels S,Radau S,Zahedi RP,Schmidt C,Dobner T,Grundhoff A,Fischer N

更新日期：2020-02-14 00:00:00

abstract：:Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antib...

journal_title：Journal of virology

authors： Hosie MJ,Willett BJ,Dunsford TH,Jarrett O,Neil JC

更新日期：1993-03-01 00:00:00

abstract：:The majority of double-stranded DNA (dsDNA) viruses infecting eukaryotic organisms use host- or virus-expressed histones or protamine-like proteins to condense their genomes. In contrast, members of the Baculoviridae family use a protamine-like protein named P6.9. The dephosphorylated form of P6.9 binds to DNA in a no...

journal_title：Journal of virology

authors： Wang M,Tuladhar E,Shen S,Wang H,van Oers MM,Vlak JM,Westenberg M

更新日期：2010-09-01 00:00:00

abstract：:Measles virus (MV) infection causes an acute childhood disease, associated in certain cases with infection of the central nervous system and development of a severe neurological disease. We have generated transgenic mice ubiquitously expressing the human protein SLAM (signaling lymphocytic activation molecule), or CD1...

journal_title：Journal of virology

authors： Sellin CI,Davoust N,Guillaume V,Baas D,Belin MF,Buckland R,Wild TF,Horvat B

更新日期：2006-07-01 00:00:00

abstract：:Antibodies against CCR5, the major coreceptor for human immunodeficiency virus type 1 (HIV-1), may have antiviral potential as viral fusion inhibitors. In this study, we generated a virus-like particle (VLP)-based vaccine that effectively breaks B-cell tolerance and elicits autoantibodies against CCR5 in pig-tailed ma...

journal_title：Journal of virology

authors： Chackerian B,Briglio L,Albert PS,Lowy DR,Schiller JT

更新日期：2004-04-01 00:00:00

abstract：:The emergence in 1997 and continuance today of a highly lethal H5N1 avian influenza virus (AIV) causing human disease has raised concern about an impending pandemic and the need for a vaccine to prepare for such an occurrence. We previously generated an efficacious vesicular stomatitis virus (VSV)-based AIV vaccine ex...

journal_title：Journal of virology

authors： Schwartz JA,Buonocore L,Suguitan AL Jr,Silaghi A,Kobasa D,Kobinger G,Feldmann H,Subbarao K,Rose JK

更新日期：2010-05-01 00:00:00

abstract：:The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The sequence relationships between the sarcoma viruses and their respective parental murine leukemia viruses (Kirsten and Mol...

journal_title：Journal of virology

authors： Chien UH,Lai M,Shih TY,Verma IM,Scolnick EM,Roy-Burman P,Davidson N

更新日期：1979-09-01 00:00:00

abstract：:The ability of the gamma(1)34.5 protein to suppress the PKR response plays a crucial role in herpes simplex virus pathogenesis. In this process, the gamma(1)34.5 protein associates with protein phosphatase 1 to form a large complex that dephosphorylates eIF-2alpha and thereby prevents translation shutoff mediated by P...

journal_title：Journal of virology

authors： Jing X,Cerveny M,Yang K,He B

更新日期：2004-07-01 00:00:00

abstract：:West Nile virus (WNV), currently the cause of a serious U.S. epidemic, is a mosquito-borne flavivirus and member of the Japanese encephalitis (JE) serocomplex. There is currently no approved human WNV vaccine, and treatment options remain limited, resulting in significant mortality and morbidity from human infection. ...

journal_title：Journal of virology

authors： Petrovsky N,Larena M,Siddharthan V,Prow NA,Hall RA,Lobigs M,Morrey J

更新日期：2013-09-01 00:00:00

abstract：:The genome of the human immunodeficiency virus type 1 (HIV-1) is highly heterogeneous. Some of this genomic variability is reflected in the biologic and serologic differences observed among various strains of HIV-1. To map the viral determinants that correlate with pathogenicity of the virus, recombinant viruses were ...

journal_title：Journal of virology

authors： Cheng-Mayer C,Quiroga M,Tung JW,Dina D,Levy JA

更新日期：1990-09-01 00:00:00

abstract：:The hepatitis C virus (HCV) envelope proteins, E1 and E2, form noncovalent heterodimers and are leading candidate antigens for a vaccine against HCV. Studies in mammalian cell expression systems have focused primarily on E2 and its folding, whereas knowledge of E1 folding remains fragmentary. We used a cell-free in vi...

journal_title：Journal of virology

authors： Merola M,Brazzoli M,Cocchiarella F,Heile JM,Helenius A,Weiner AJ,Houghton M,Abrignani S

更新日期：2001-11-01 00:00:00

abstract：:Recent studies indicate that expansion of NKG2C-positive natural killer (NK) cells is associated with human cytomegalovirus (HCMV); however, their activity in response to HCMV-infected cells remains unclear. We show that NKG2C(hi) CD57(hi) NK cells gated on CD3(neg) CD56(dim) cells can be phenotypically identified as ...

journal_title：Journal of virology

authors： Wu Z,Sinzger C,Frascaroli G,Reichel J,Bayer C,Wang L,Schirmbeck R,Mertens T

更新日期：2013-07-01 00:00:00

abstract：:The potential role of T cells in the control of human papillomavirus type 6 (HPV-6) infections is an appealing premise, but their actual role has been sparsely investigated. Since HPV-6 infections are confined to the epithelium, such an investigation should focus on the T cells present at the site of infection (i.e., ...

journal_title：Journal of virology

authors： Hong K,Greer CE,Ketter N,Van Nest G,Paliard X

更新日期：1997-09-01 00:00:00

abstract：:The genome of all densoviruses (DNVs) so far isolated from mosquitoes or mosquito cell lines consists of a 4-kb single-stranded DNA molecule with a monosense organization (genus Brevidensovirus, subfamily Densovirinae). We previously reported the isolation of a Culex pipiens DNV (CpDNV) that differs significantly from...

journal_title：Journal of virology

authors： Baquerizo-Audiot E,Abd-Alla A,Jousset FX,Cousserans F,Tijssen P,Bergoin M

更新日期：2009-07-01 00:00:00