[Importance of the structure of the clot in thrombolysis].

Abstract:

:Activation of plasminogen by tissue-type plasminogen activator (tpA) is potentiated by fibrin. We have demonstrated the role of fibrin polymerization in the potentiating effect of tpA-induced fibrinolysis. Therefore a pathogenic mechanism of thrombotic disorder may be related to an abnormal fibrin polymerization: the abnormal clot being less accessible to fibrinolysis than normal one. This defective lysis may be due to a defective enhancement by the abnormal fibrin of plasminogen activation by tpA, as demonstrated for fibrinogen Dusard, a congenital dysfibrinogenemia associated with a very severe thrombotic disorder. In some other cases, a decrease in the availability of the plasmin cleavage sites in fibrin clot may be involved. On the contrary, some antithrombotic drugs such as pentosane polysulfate in modifying clot structure allow a better degradation of fibrin clot by fibrinolytic enzymes. It is speculated that this enhanced fibrinolysis could explain, almost in part, the antithrombotic action of these drugs.

journal_name

Ann Biol Clin (Paris)

authors

Soria C,Soria J,Mirshahi M,Desvignes P,Bonnet P,Caen JP

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

207-11

issue

2

eissn

0003-3898

issn

1950-6112

journal_volume

45

pub_type

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