Abstract:
:Anti-erythrocyte alloimmunization may occur following the transfusion of platelet concentrates, in response to the presence of residual erythrocytes. Immunization against RH1 (D) antigen is the most frequent, but transfusion of RH1 compatible platelet concentrates is not always possible because of supply constraints. We report here three cases of anti-RH1 (anti-D) alloimmunization in RH :-1 patients after transfusion of platelet concentrates from RH :1 donors. Criteria for selection of platelet concentrates are numerous and difficult to achieve in practice. Respect of RH1 compatibility is not obligatory, but in case of transfusion of RH1 incompatible platelet concentrates, anti-RH1 immunoprophylaxis must be made for RH :-1 women of child-bearing age and without profound immunosuppression, as recommended by Afssaps (Agence française de sécurité sanitaire des produits de santé). These data point out the need to perform post-transfusional screening test for irregular erythrocyte antibodies as part of the transfusion of platelet concentrates.
journal_name
Ann Biol Clin (Paris)journal_title
Annales de biologie cliniqueauthors
Duboeuf S,Flourié F,Courbil R,Oriol P,Benamara A,Chartier M,Rigal E,Garraud Odoi
10.1684/abc.2009.0336subject
Has Abstractpub_date
2009-05-01 00:00:00pages
353-7issue
3eissn
0003-3898issn
1950-6112pii
abc.2009.0336journal_volume
67pub_type
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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