Abstract:
BACKGROUND:Chemoradiotherapy has become the standard of care for head and neck squamous cell carcinoma; however, those patients often experience multiple treatment-related symptoms or symptom clusters. Two symptom clusters have been identified for this population. Little is known about the risk factors of these symptom clusters. METHODS:Subjects comprised 684 patients who were treated with concurrent chemoradiotherapy in a phase 3 randomized clinical trial. This trial compared standard fractionation radiotherapy to accelerated fractionation radiotherapy. Symptom clusters were evaluated at the end of the first and the second cycle of chemotherapy, and 3 months after the start of radiotherapy. Mixed-effect modeling was used to observe risk factors for symptom clusters. RESULTS:Race and education were independent predictors for the head and neck cluster, whereas sex and history of tobacco use were independent predictors for the gastrointestinal cluster. Primary cancer site was only significant for the head and neck cluster when other factors were not controlled: patients with oropharyngeal cancer had more severe symptoms in the head and neck clusters than did patients with laryngeal cancer. In addition, patients receiving accelerated fractionation radiotherapy experienced more symptoms of radiomucositis, pain, and nausea at 3 months after the start of radiotherapy than those receiving standard fractionation radiotherapy. CONCLUSIONS:Demographic characteristics were more predictive to symptom clusters, whereas clinical characteristics, such as cancer site and treatment arms, were more significant for individual symptoms. Knowing the risk factors will enhance the capability of clinicians to evaluate patients' risk of severe symptom clusters and to personalize management strategies.
journal_name
Cancerjournal_title
Cancerauthors
Xiao C,Hanlon A,Zhang Q,Movsas B,Ang K,Rosenthal DI,Nguyen-Tan PF,Kim H,Le Q,Bruner DWdoi
10.1002/cncr.28500subject
Has Abstractpub_date
2014-03-15 00:00:00pages
848-54issue
6eissn
0008-543Xissn
1097-0142journal_volume
120pub_type
杂志文章,随机对照试验相关文献
CANCER文献大全abstract::The plasma levels of the immunoglobulins IgA, IgG and IgM have been measured in 55 patients with benign breast disease, 28, 68 and 22 patients with early breast cancer one day before, 10-14 days after and three-six months after mastectomy, respectively, and 35 normal healthy control women. The mean levels of IgA, IgG ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<2190::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) has immunomodulatory effects, including stimulating the activity of cytotoxic T cells and natural killer cells, and inducing the generation of lymphokine-activated killer cells. The authors investigated whether IL-2 may improve the duration of complete remission (CR) and survival in acut...
journal_title:Cancer
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in situ carcinoma provides an op...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990701)86:1<31::aid-cncr
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:AEs observed during 1 of 3 randomized chemotherapy regimens (vincristine, dactinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26358
更新日期:2012-02-15 00:00:00
abstract::Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197801)41:1<23::aid-cncr28204101
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Ligand activation of peroxisome proliferator-activated receptor gamma (PPARgamma) results in the inhibition of proliferation of various cancer cells. The aim of this study is to investigate the mechanisms of cell growth inhibition of hepatocellular carcinoma (HCC) cell lines by the PPARgamma ligand, troglita...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10906
更新日期:2002-11-15 00:00:00
abstract::This report is to make the general scientific community aware of availability of human tissues through this network. During the short period of its existence, this network has developed useful procedures for distributing human tumor tissue in a rapid, scientifically useful, cost-effective manner to investigators to wh...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890401)63:7<1452::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:In a recently reported, randomized trial, it was found that a regimen of irinotecan once every 3 weeks for patients with advanced colorectal carcinoma was associated with a lower incidence of severe diarrhea compared with weekly treatment, and both regimens had similar efficacy. METHODS:Resource utilization...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.20691
更新日期:2004-12-01 00:00:00
abstract::Delayed cutaneous hypersensitivity to 2,3-dinitrochlorobenzene (DNCB) was tested in 419 patients with malignant melanoma to determine whether DNCB reactivity was associated with prognosis. At the time of definitive surgery, a positive DNCB test was seen in 82% of the patients in State I (regional lymph node histologic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2446::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract:BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921115)70:10<2410::aid-cncr282
更新日期:1992-11-15 00:00:00
abstract:BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27877
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21853
更新日期:2006-05-15 00:00:00
abstract::The authors discovered some errors regarding reference group labels in Table 2. The corrected table is attached. The authors regret these errors. ...
journal_title:Cancer
pub_type: 已发布勘误
doi:10.1002/cncr.29118
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Reconstruction is rarely incorporated into the decision-making process for surgical breast cancer treatment. We examined the importance of knowing about reconstruction to patients' surgical decision-making for breast cancer. METHODS:We surveyed women aged < or =79 years with breast cancer (N = 1844) who wer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23214
更新日期:2008-02-01 00:00:00
abstract::The observation, in 1980, of a rapid increase in platelet counts as a result of administration of intravenous immunoglobulin (IVIG) in a patient with immune thrombocytopenic purpura (ITP) was followed by clinical studies confirming the efficacy of this new treatment alternative in ITP. Simultaneously, new sensitive as...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910915)68:6+<1422::aid-cncr282
更新日期:1991-09-15 00:00:00
abstract:METHODS:The diagnostic performance of transrectal ultrasound (TRUS) gland volume and prostate specific antigen (PSA) results were evaluated in 204 men consecutively scheduled to undergo transurethral prostatic resection (TUR). RESULTS:Nonpalpable prostate cancer was detected by TRUS alone in 18% (29 of 161) and by TUR...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920701)70:1+<211::aid-cncr2820
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Although >70% of younger women with nonmetastatic breast cancer (BC) received adjuvant chemotherapy, only approximately 15% to 20% of elderly women with BC received chemotherapy. The decision to treat may be associated with nonmedical factors, such as patient, physician, or practice characteristics. In the c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24448
更新日期:2009-09-01 00:00:00
abstract::A 49-year-old white woman with refractory anemia subsequently developed acute myelomonocytic leukemia with paraproteinemia 12 months later. The paraprotein was characterized as immunoglobulin G, type kappa, and the Bence Jones protein as free kappa chains. Further studies, including electron microscopy, cytochemistry,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1359::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:A series of retrospective studies have reported that patients with human epidermal growth factor receptor 2(HER2)-positive breast cancer are at a greater risk of central nervous system (CNS) metastases. Trastuzumab, which does not cross the blood-brain barrier, has been associated with this increased risk. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25771
更新日期:2011-05-01 00:00:00
abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<301::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:Crizotinib is a tyrosine kinase inhibitor active against ALK, MET, and ROS1. We previously reported that crizotinib decreases testosterone in male patients. The detailed etiology of the effect, its symptomatic significance, and the effectiveness of subsequent testosterone replacement have not been previously...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28089
更新日期:2013-07-01 00:00:00
abstract::Seventy-seven patients with relapsed or refractory acute leukemia and three with acute blastic chronic myeloid leukemia (CML) were treated in an open Phase II study using mitoxantrone 12 mg/m2 intravenously daily X 5 days. Complete remission (CR) was achieved in 32 of 80 (40%), including 23/45 (52%) with relapsed acut...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19900801)66:3<418::aid-cncr28206
更新日期:1990-08-01 00:00:00
abstract::Mixed cellularity Hodgkin's disease and diffuse non-Hodgkin's lymphoma, mixed cell type, occurred consecutively in a husband and wife. Both patients demonstrated monoclonal IgM gammopathies. The unusual nature and possible significance of these findings are discussed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<277::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS:Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder muta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11310
更新日期:2003-05-01 00:00:00
abstract::One-hundred-eighty-eight children up to 16 years of age were randomized in the second National Wilms' Tumor Study (NWTS) with tumors that were confined to the kidney and that had been totally excised (Group I). Most fared well whether treated for six or for 15 months with both actinomycin D (AMD) and vincristine (VCR)...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810501)47:9<2302::aid-cncr2820
更新日期:1981-05-01 00:00:00
abstract:BACKGROUND:Postchemotherapy surgery is an essential component in the management of patients with metastatic germ cell tumors (GCT). The authors assessed their institutional experience of retroperitoneal lymph node dissection (RPLND) after multiple chemotherapy regimens for advanced GCT. METHODS:By analyzing the instit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22440
更新日期:2007-02-01 00:00:00
abstract::Between July 1951 and January 1984, 14 female patients (11 black and three white; average age, 58 years) were treated for primary urethral carcinoma. Five patients had radical surgery, six received preoperative radiotherapy (2000 cGy in five fractions) followed by anterior exenteration, and three had definitive radiot...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880701)62:1<54::aid-cncr282062
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:To assess the ability of [(18)F]fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) to predict the viability of residual masses after chemotherapy in patients with metastatic nonseminomatous germ cell tumors (GCT), PET results were compared in a blinded analysis with computed tomography (CT) sca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10494
更新日期:2002-05-01 00:00:00
abstract::Forty-nine patients with transitional urothelial tract tumors received methotrexate: 0.5-1.0 mg/kg I.V. Q W (40 patients) or 250 mg/M2 in a 2-hour infusion with citrovorum factor rescue 24 hours later (nine patients). Eleven (26%, 95% confidence limits 13-39%) of 42 patients with bidimensionally measurable metastases ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1246::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract::The short term addition of nandrolone decanoate to combination chemotherapy given to patients with unresectable non-small cell lung cancer was evaluated in a randomized, prospective trial. Patients were treated with doxorubicin 50 mg/M2 intravenously, cyclophosphamide 300 mg/M2 intravenously, CCNU 50 mg/M2 orally, vin...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19860701)58:1<183::aid-cncr28205
更新日期:1986-07-01 00:00:00