Abstract：
BACKGROUND/OBJECTIVES:We investigated whether C-reactive protein (CRP) as indicator of acute inflammation is associated with maximal isometric handgrip strength in non-critically ill patients. SUBJECTS/METHODS:Handgrip strength was measured with Jamar dynamometer in 620 hospitalized patients (56.4±15.9 years old, 52.3% men). CRP was measured with immunoturbidimetric assay. Fat free mass (FFM) was assessed by bioelectrical impedance analysis. A general linear model regression analysis corrected for confounding variables such as age, sex, FFM, body mass index, comorbidity count and diagnosis category (malignant/benign disease) was performed to test the association between elevated levels of CRP and handgrip strength. RESULTS:CRP was an independent predictor of grip strength (CRP: β-coefficient: -0.169, P=0.018) even after adjustment for relevant confounders. All groups with inflammation showed significant reduction in handgrip strength, corresponding to a loss of ∼1.6 kg in mild inflammation, 3.2 kg in moderate inflammation and 2.9 kg in severe inflammation compared with patients without inflammation. DISCUSSION:Our data demonstrate the independent association between inflammation and handgrip strength in non-critically ill patients. If not corrected, reduced strength may have implications for the patients' functional status and prognosis. Increasing physical activity and resistance training during convalescence are recommended.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Norman K,Stobäus N,Kulka K,Schulzke Jdoi
10.1038/ejcn.2013.261subject
Has Abstractpub_date
2014-02-01 00:00:00pages
155-8issue
2eissn
0954-3007issn
1476-5640pii
ejcn2013261journal_volume
68pub_type
杂志文章abstract：:The effect of mazindol given orally on gastric emptying of a radiolabelled solid meal was examined in 10 obese females. The patients underwent the measurement of gastric emptying twice: 2 mg mazindol was compared with placebo according to a double-blind study protocol. Mazindol significantly delayed gastric emptying (...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:In most populations the prevalence of obesity is greater in women than in men; however, the magnitude of the difference between the sexes varies significantly by country. We considered the role of gender inequality in explaining these disparities. SUBJECTS/METHODS:We undertook an ecological analy...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.86
更新日期：2014-10-01 00:00:00
abstract：:We conducted a mini-review of the literature, focusing on aging-related systemic inflammation and its association with vitamin D (VitD). As main findings, data indicate that inflammation in aging seems to have multiple origins, including immunosenescence, and from intestinal and adipose tissue, where VitD may modulate...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2016.177
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:We set up a baseline data on urinary iodine excretion from a nationwide representative sample of rural schoolchildren before instituting iodine supplementation. DESIGN:Stratified multistage cluster sampling in three different strata: lowlands, foothills and mountainous areas. Early morning urine samples were...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600562
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Few studies have examined the effects of the weight status at birth and preschool age on the risk of elevated blood pressure (EBP) in early childhood, and whether the effects can be modified by breastfeeding duration remains unclear. We aimed to evaluate the effects of high birth weight (HBW) with...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-0608-5
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Coffee is one of the most popularly consumed beverages worldwide. Many epidemiological studies have investigated the association between coffee consumption and lung cancer risk, but the results are inconsistent. Hence, we conducted a systematic analysis of relevant population-based studies to exam...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1038/ejcn.2015.96
更新日期：2016-02-01 00:00:00
abstract：:As part of the Euronut SENECA study, food consumption has been assessed in 1217 men and 1241 women, born between 1913 and 1918 and living in 18 towns in 12 European countries. The method used was a standardized modified dietary history, including a 3-day estimated record and a food frequency list based on local food p...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：OBJECTIVES:Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years. METHODS:Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602790
更新日期：2008-05-01 00:00:00
abstract：:The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade. This review evaluates the evidence, and concludes that there is limited evidence for a w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2010.240
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Malnutrition is a common and underrecognized clinical problem among aged institutionalized patients. The aim of this study was to investigate how well nurses recognize malnutrition in elderly patients in long-term care hospitals in Helsinki. SUBJECTS AND METHODS:In this descriptive, cross-sect...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602916
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Young Indian adults are at greater risk of overweight/obesity due to their high energy intake and sedentary lifestyle. Their energy requirement (ER) is based on their total energy expenditure (TEE) estimated from factorial method, which possibly overestimates their basal metabolic rate (BMR) and p...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00790-5
更新日期：2020-10-24 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies. SUBJECTS AND METHODS:Twenty-six women born between 1940 and 1950 were recruited ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602811
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To assess the potential impact of a national iron supplementation programme in rural Vietnam. METHODS:The study included questionnaires, focus group discussions of pregnant women and key informant interviews, together with measurements of haemoglobin (Hb) and a stool examination for soil-transmitted helminth...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602812
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:It is hypothesised that epigenetic mechanisms including DNA methylation may underlie the relationship between early-life nutrition and child cognitive outcomes. This study aimed to identify dietary patterns associated with the intake of one-carbon metabolism nutrients in children aged 2-3 years. METHODS:A v...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0376-7
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the bifidogenic efficacy of two inulin doses in healthy human adults. DESIGN:A double-blind, placebo-controlled, crossover human study. SETTING:Food Microbial Sciences Unit, The University of Reading, Reading, UK. SUBJECTS:Thirty healthy volunteers, 15 men, 15 women (age range 19-35). INTERVEN...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602636
更新日期：2007-10-01 00:00:00
abstract：:Hypothalamic amenorrhoea has been shown to be associated with hypercarotenaemia, but no causal link has been established. Many people are unaware of the health implications of carotenoderma. We report on a 36-year-old woman with normal body mass index and with a history of secondary amenorrhoea for 2 years and caroten...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.128
更新日期：2014-12-01 00:00:00
abstract：:The purpose of this paper is to assess the food habits of the Spanish population and the composition of the fat consumed. The national food survey data have been used. This survey was carried out during one week in a representative sample of households by means of recorded weighing or the household measures method. Th...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To examine the influence of intense sweetener consumption on nutrient intakes in insulin dependent diabetics compared to controls. DESIGN:Case-control food consumption survey. SETTING:Dietary data were collected from individuals in Ireland between 1998 and 1999. SUBJECTS:Diabetics were recruited through di...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601969
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:We previously demonstrated that acute exposure to hypoxia (3 h at 3000 m) increased oxidative stress markers. Thus, by using the 'living high-training low' (LHTL) method, we further hypothesized that intermittent hypoxia associated with endurance training alters the prooxidant/antioxidant balance....
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：10.1038/ejcn.2008.30
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between selenium nutritional status and intermediates of human immunodeficiency virus (HIV)-1 transmission. DESIGN:Prospective cohort study. SETTING:A study clinic at Muhimbili National Hospital, Dar es Salaam, Tanzania. SUBJECTS:A total of 340 HIV-1-infected pregnant women with...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602567
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:There is experimental evidence that riboflavin (vitamin B2) supplementation reduces oxidative damage and cerebral oedema following acute stroke. OBJECTIVE:To measure riboflavin levels in acute stroke before and after supplementation with this vitamin. DESIGN:Ninety-six acute ischaemic stroke patients had t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602666
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Exclusive enteral nutrition (EEN) is a safe and effective treatment modality for inducing remission in paediatric Crohn's disease (CD). The primary aim of this study was to compare the outcomes of EEN to corticosteroid (CS) therapy in newly diagnosed, treatment-naïve patients with CD. A secondary ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.210
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:To compare validation of reported dietary intakes from weighed records against urinary nitrogen excretion and energy expenditure measured by DLW, and to examine the utility of the Goldberg cut-off for EI:BMR in the identification of under-reporters. DESIGN:Energy (EI) and nitrogen (protein) intake (NI) were...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600425
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Diet quality indices are increasingly used in nutrition epidemiology as dietary exposures in relation to health outcomes. However, literature on the long-term stability of these indices is limited. We aimed to assess the stability of the validated Framingham Nutritional Risk Score (FNRS) and its c...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.167
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Recent studies have demonstrated beneficial metabolic effects of dietary monounsaturated fatty acids (MUFA) in Type-2 diabetes mellitus (Type-2 DM). The question arises if dietary MUFA also has desirable effects on risk markers in subjects with high risk of developing Type-2 DM. SETTING:University department...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600855
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The aim of this study was to evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) with disability and frequency of relapses in relapsing-remitting multiple sclerosis (MS) patients. SUBJECTS/METHODS:The study included 184 patients with relapsing-remitting MS who were receiving immune-mo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.51
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:The relationship between hydrogen and methane production is a possible confounding factor in the interpretation of H(2) breath tests (HBT), but is usually disregarded for the interpretation of HBT and, in most instances, only H(2) excretion is measured. The present study was designed to evaluate the effect o...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601651
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVES:Study 1: To establish the validity of scores on Nutrition Screening Tool for Every Preschooler (NutriSTEP), a community-based parent-administered screening tool for assessing nutrition risk, by comparing scores to an expert rating. Study 2: To demonstrate test-retest reliability of NutriSTEP. SUBJECTS/METHO...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602780
更新日期：2008-06-01 00:00:00
abstract：:A service evaluation of a pilot of a family-based behavioural management group programme for childhood obesity was conducted in a community setting in the United Kingdom. A total of 17 families with children aged 7.5-14 years completed the programme, which was delivered in 15 sessions over 6 months. Behavioural and ps...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.23
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the effect of vitamin A supplementation 24 h after delivery on breastmilk retinol concentration. METHODS:Fifty low income women were randomly assigned to a single oral dose of 209 micromol of Vitamin A or none at delivery. Maternal serum and breastmilk retinol levels and infant morbidity and ant...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1600398
更新日期：1997-05-01 00:00:00
