当前位置： SCI文献检索 > JOURNAL OF BONE AND MINERAL METABOLISM期刊下所有文献 > Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.

Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.

Abstract：

:Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhances ECM synthesis and proliferation of chondrocytes by regulating K(+) channel activity, we here investigated the effects of millimeter waves on ECM synthesis, chondrocyte proliferation and ion channels in the primary chondrocyte culture. We found that millimeter waves led to the increase of chondrocyte viability, the morphological changes of chondrocyte, and the F-actin distortion and remodeling. Ultrastructural analysis showed that treated chondrocytes contained an expansion of mitochondria and granular endoplasmic reticulum, and a high number of cytoplasmic vesicles in the cytoplasm compared to untreated cells, suggesting millimeter waves increased the energy metabolism and protein synthesis of chondrocytes. The analysis of differential ion channels' genes expression further showed an obvious increase of Kcne1, Kcnj3 and Kcnq2. To determine the role of voltage-gated K(+) channel in chondrocyte, we blocked the voltage-gated K(+) channel with 10 mM tetraethylammonium (TEA) and treated chondrocytes with millimeter waves. The results indicated that TEA significantly negated the promotion of millimeter waves for the ECM synthesis and chondrocyte proliferation. Our results support the hypothesis that millimeter waves promote the synthesis of ECM and the proliferation of chondrocyte by regulating the voltage-gated K(+) channel.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Li X,Liu C,Liang W,Ye H,Chen W,Lin R,Li Z,Liu X,Wu M

doi

10.1007/s00774-013-0513-2

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

367-77

issue

4

eissn

0914-8779

issn

1435-5604

journal_volume

32

pub_type

杂志文章

相关文献

JOURNAL OF BONE AND MINERAL METABOLISM文献大全
  • Number and severity of prevalent vertebral fractures and the risk of subsequent vertebral fractures in Japanese women with osteoporosis: results from the minodronate trial.

    abstract：:The aim was to evaluate the risk of new vertebral fractures with the increasing number and severity of prevalent vertebral fractures in women who received placebo or minodronate in a post hoc analysis of a 2-year randomized, double-blind, placebo-controlled study. The subjects were women aged 55-80 years old with 1-5 ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-013-0439-8

    authors： Hagino H,Shiraki M,Fukunaga M,Nakano T,Takaoka K,Ohashi Y,Nakamura T,Matsumoto T

    更新日期：2013-09-01 00:00:00

  • Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency.

    abstract：:In this study, we focused on collagen metabolism as a factor involved in menatetrenone (MK-4)-related improvement in bone quality. Using rats with a congenital ascorbic acid (AA) deficiency, osteogenic disorder Shionogi (ODS) rats, we established a model in which abnormal collagen metabolism reduced bone mechanical pr...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0069-3

    authors： Hara K,Akiyama Y

    更新日期：2009-01-01 00:00:00

  • Trochanteric hip fracture in an elderly patient with leprosy during osteoporosis treatment with risedronate and alfacalcidol.

    abstract：:There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0546-7

    authors： Kanaji A,Higashi M,Namisato M,Ando K,Nakagawa M,Yato Y,Ichinose H,Sakamaki T,Yamada H

    更新日期：2005-01-01 00:00:00

  • Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia.

    abstract：:McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia. However, it remains unclear whether a humoral factor is associated with the cause of hypophosphatemia. We isolated cells with mutations of the Gsalpha gene from fibrous bone dysplasia tissues of two MAS patients (MAS cells). Severe combined i...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170012

    authors： Yamamoto T,Miyamoto KI,Ozono K,Taketani Y,Katai K,Miyauchi A,Shima M,Yoshikawa H,Yoh K,Takeda E,Okada S

    更新日期：2001-01-01 00:00:00

  • Adequate vitamin D status and adiposity contribute to bone health in peripubertal nonobese children.

    abstract：:The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-012-0419-4

    authors： Lee YA,Kim JY,Kang MJ,Chung SJ,Shin CH,Yang SW

    更新日期：2013-05-01 00:00:00

  • Structuring of parameters for assessing vertebral bone strength by star volume analysis using a morphological filter.

    abstract：:Based on the relationship between bone strength, trabecular skeletal structure, and bone mineral density (BMD), structure parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra of elderly persons. The trabecular bone pattern of each bone block was b...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170035

    authors： Tanaka T,Sakurai T,Kashima I

    更新日期：2001-01-01 00:00:00

  • Texture analysis of X-ray radiographs is correlated with bone histomorphometry.

    abstract：:Three-dimensional (3D) alteration of trabecular microarchitecture is a risk factor for vertebral fractures. Histomorphometry allows microarchitectural analysis of bone, but the necessity to perform a transiliac bone biopsy limits its use in large series of patients. X-Ray films are commonly used in routine practice an...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0536-9

    authors： Chappard D,Guggenbuhl P,Legrand E,Baslé MF,Audran M

    更新日期：2005-01-01 00:00:00

  • The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients.

    abstract：:It has been suggested that there are several possible linkages between vascular calcification and osteoporosis. In addition, the processes of vascular calcification may have a common etiology with bone formation. Thus, we hypothesized that the serum levels of bone metabolic markers would be different between osteoporo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0528-9

    authors： Iba K,Takada J,Yamashita T

    更新日期：2004-01-01 00:00:00

  • Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain.

    abstract：:The present study examined the early effects of prostaglandin (PG)E2 on proximal tibial metaphyses of 20-month-old Wistar male rats. PGE, was given to intact rats for 10 and 30 days at 3mg/kg/day. After multiple in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170057

    authors： Cui L,Ma YF,Yao W,Zhou H,Setterberg RB,Liang TC,Jee WS

    更新日期：2001-01-01 00:00:00

  • Higher response with bone mineral density increase with monthly injectable ibandronate 1 mg compared with oral risedronate in the MOVER study.

    abstract：:We examined response to bone mineral density (BMD) gains in the MOVER study following treatment with intravenous (IV) ibandronate 1 mg/month, and investigated the characteristics of a non-responder group. At 1 year, responder rates for patients with BMD increases >0 % were similar with IV ibandronate 0.5 or 1 mg/month...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-015-0717-8

    authors： Nakano T,Yamamoto M,Hashimoto J,Tobinai M,Yoshida S,Nakamura T

    更新日期：2016-11-01 00:00:00

  • Assessment of adherence to treatment of postmenopausal osteoporosis with raloxifene and/or alfacalcidol in postmenopausal Japanese women.

    abstract：:Patients who are diagnosed with osteoporosis and beginning treatment often discontinue their osteoporosis medication relatively early after the start of treatment because of their poor recognition of fracture risk and the asymptomatic nature of osteoporosis. In this study we aimed to assess adherence to treatment with...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-009-0112-4

    authors： Gorai I,Tanaka Y,Hattori S,Iwaoki Y

    更新日期：2010-03-01 00:00:00

  • Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine.

    abstract：:Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-017-0844-5

    authors： Daghma DES,Malhan D,Simon P,Stötzel S,Kern S,Hassan F,Lips KS,Heiss C,El Khassawna T

    更新日期：2018-05-01 00:00:00

  • Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats.

    abstract：:Bone is a specialized connective tissue that functions as the load-bearing structure of the body. Free radicals may affect bone remodeling by regulating osteoclast activity in either the physiological or pathological condition. Vitamin E, a lipid-soluble antioxidant, has been demonstrated to offer protection against o...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0159-2

    authors： Mehat MZ,Shuid AN,Mohamed N,Muhammad N,Soelaiman IN

    更新日期：2010-09-01 00:00:00

  • Fructooligosaccharides prevent disorders of the femoral neck following gastrectomy in growing rats.

    abstract：:Gastrectomy-evoked osteopenia in the femoral metaphysis of rats can be prevented by the consumption of fructooligosaccharides (FOS). We examined the effect of FOS on the femoral neck. Twenty-eight 5-week-old male Sprague-Dawley rats were divided into two groups, sham-operated (SH) and gastrectomized (GX). One week aft...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0423-9

    authors： Hirama Y,Morohashi T,Sano T,Maki K,Ohta A,Sakai N,Yamada S,Sasa R

    更新日期：2003-01-01 00:00:00

  • Low calcium intake is associated with decreased adrenal androgens and reduced bone age in premenarcheal girls in the last pubertal stages.

    abstract：:In 50 premenarcheal girls selected from the lowest and highest end of the calcium-intake distribution of a large population sample, we evaluated bone mineral density (BMD), together with the following hormonal-metabolic parameters: androstenedione (ASD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (D...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0451-5

    authors： Bonofiglio D,Garofalo C,Catalano S,Marsico S,Aquila S,Andò S

    更新日期：2004-01-01 00:00:00

  • Effects of manganese deficiency on serum hormones and biochemical markers of bone metabolism in chicks.

    abstract：:In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-012-0417-6

    authors： Zhaojun W,Lin W,Zhenyong W,Jian W,Ran L

    更新日期：2013-05-01 00:00:00

  • Growth pattern of lumbar bone mineral content and trunk muscles in adolescent male soccer players.

    abstract：INTRODUCTION:Previous studies have reported that the peak in lean body mass (LBM) precedes the peak in bone mineral content (BMC). However, it is unknown whether the trunk region growth is similar. MATERIALS AND METHODS:We investigated the difference between pubertal peak age in the increase of LBM in the trunk (trunk...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01060-6

    authors： Takei S,Taketomi S,Tanaka S,Torii S

    更新日期：2020-05-01 00:00:00

  • Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study.

    abstract：:The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00774-013-0529-7

    authors： Vasic J,Petranova T,Povoroznyuk V,Barbu CG,Karadzic M,Gojkovic F,Elez J,Winzenrieth R,Hans D,CulaficVojinovic V,Poiana C,Dzerovych N,Rashkov R,Dimic A

    更新日期：2014-09-01 00:00:00

  • Osteoporosis following chronic constriction injury of sciatic nerve in rats.

    abstract：:Osteopathic changes sometimes occur in patients with complex regional pain syndrome (reflex sympathetic dystrophy and causalgia). We aimed to investigate whether such osteopathic changes occurred in rats with chronic constriction injury (CCI) of the sciatic nerve. A CCI of the sciatic nerve was established in a unilat...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740200012

    authors： Suyama H,Moriwaki K,Niida S,Maehara Y,Kawamoto M,Yuge O

    更新日期：2002-01-01 00:00:00

  • Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells.

    abstract：:Rodent hindlimb unloading (HU) by tail-suspension is a model to investigate disuse-induced bone loss in vivo. Previously, we have shown that osteopontin (OPN, also known as Spp1) is required for unloading-induced bone loss. However, how unloading affects OPN expression in the body is not fully understood. Here, we exa...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0568-8

    authors： Ezura Y,Nagata J,Nagao M,Hemmi H,Hayata T,Rittling S,Denhardt DT,Noda M

    更新日期：2015-01-01 00:00:00

  • The relationship between radiological parameters from plain hip radiographs and bone mineral density in a Korean population.

    abstract：:The purpose of this study was to investigate the association of the Singh index, cortical thickness index (CTI) and calcar-to-canal (CC) ratio with bone mineral density (BMD) as well as their relationship with physical parameters [age, gender, height, and body mass index (BMI)] in order to assess their potential as an...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-012-0348-2

    authors： Im GI,Park PG,Moon SW

    更新日期：2012-09-01 00:00:00

  • The effect of a single dose versus a daily dose of cholecalciferol on the serum 25-hydroxycholecalciferol and parathyroid hormone levels in the elderly with secondary hyperparathyroidism living in a low-income housing unit.

    abstract：:We designed a randomized, double-blind, controlled clinical trial to compare the effect of two regimens for administering cholecalciferol on the serum 25-hydroxycholecalciferol [25(OH)D] levels and in the reversion of secondary hyperparathyroidism in the elderly living in a low-income housing unit in the city of Porto...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-008-0858-0

    authors： Premaor MO,Scalco R,da Silva MJ,Froehlich PE,Furlanetto TW

    更新日期：2008-01-01 00:00:00

  • Runx-2 gene expression is associated with age-related changes of bone mineral density in the healthy young-adult population.

    abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-012-0373-1

    authors： Zanatta M,Valenti MT,Donatelli L,Zucal C,Dalle Carbonare L

    更新日期：2012-11-01 00:00:00

  • The association between CD31hiEmcnhi endothelial cells and bone mineral density in Chinese women.

    abstract：:Osteoporosis is the most common bone disease in humans. During bone remodeling, specialized blood vessels influenced by the endothelial cells (CD31hiEmcnhi, also called type H cells) are formatted to supply nutrients. Reductions in vascular supply are associated with bone loss resulting in osteoporosis. Therefore, the...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01000-4

    authors： Zhu Y,Ruan Z,Lin Z,Long H,Zhao R,Sun B,Cheng L,Tang L,Xia Z,Li C,Zhao S

    更新日期：2019-11-01 00:00:00

  • CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations.

    abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0659-7

    authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

    更新日期：2006-01-01 00:00:00

  • Sclerostin, preadipocyte factor-1 and bone mineral values in eumenorrheic adolescent athletes with different training patterns.

    abstract：INTRODUCTION:The specific aims of the study were to compare possible differences in sclerostin and preadipocyte factor-1 (Pref-1) between rhythmic gymnasts (RG), swimmers (SW) and untrained controls (UC), and to investigate the relationships of sclerostin and Pref-1 with bone mineral characteristics in studied groups. ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01141-x

    authors： Jürimäe J,Karvelyte V,Remmel L,Tamm AL,Purge P,Gruodyte-Raciene R,Kamandulis S,Maasalu K,Gracia-Marco L,Tillmann V

    更新日期：2020-09-02 00:00:00

  • Analysis of Ca2+ response of osteocyte network by three-dimensional time-lapse imaging in living bone.

    abstract：:Osteocytes form a three-dimensional (3D) cellular network within the mineralized bone matrix. The cellular network has important roles in mechanosensation and mechanotransduction related to bone homeostasis. We visualized the embedded osteocyte network in chick calvariae and observed the flow-induced Ca2+ signaling in...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-017-0868-x

    authors： Tanaka T,Hoshijima M,Sunaga J,Nishida T,Hashimoto M,Odagaki N,Osumi R,Aadachi T,Kamioka H

    更新日期：2018-09-01 00:00:00

  • Persistence with osteoporosis medication among newly-treated osteoporotic patients.

    abstract：:Low persistence with osteoporosis medication is associated with higher fracture risk. Previous studies estimated that 1-year persistence with osteoporosis medication is low. Our aim was to study persistence with osteoporosis medication among patients with long-term follow-up (to 5 years). The InterAction Database (IAD...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0440-2

    authors： van Boven JF,de Boer PT,Postma MJ,Vegter S

    更新日期：2013-09-01 00:00:00

  • Nontraumatic lumbar vertebral compression fracture as a risk factor for femoral neck fractures in involutional osteoporotic patients.

    abstract：:To screen a potential risk factor for femoral neck fracture, we characterized lumbar vertebral fractures in 120 patients with femoral neck fractures (19 men, 101 women; mean age, 78.7 years) by investigating the frequency of patients with lumbar vertebral fracture, the number of vertebral fractures per patient, and th...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740050085

    authors： Kinoshita T,Ebara S,Kamimura M,Tateiwa Y,Itoh H,Yuzawa Y,Takahashi J,Takaoka K

    更新日期：1999-01-01 00:00:00

  • Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.

    abstract：:Nitrogen-containing bisphosphonates such as zoledronic acid (ZOL) and pamidronate have been widely and successfully used for the treatment of cancer patients with bone metastases and/or hypercalcemia. Accumulating recent reports have shown that cancer patients who have received these bisphosphonates occasionally manif...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0128-9

    authors： Kobayashi Y,Hiraga T,Ueda A,Wang L,Matsumoto-Nakano M,Hata K,Yatani H,Yoneda T

    更新日期：2010-03-01 00:00:00