Lymphocyte subpopulations in patients with alcoholic liver disease.

Abstract:

:To determine whether abnormalities of the lymphocyte populations are associated with alcoholic liver disease, we have characterized the subpopulations of lymphocytes in 30 alcoholic patients with and without liver disease. Total T lymphocytes were decreased in patients with alcoholic hepatitis and alcoholic cirrhosis. However, T4 (helper) and T8 (suppressor/cytotoxic) cells and the T4 and T8 cell ratio were similar to the values in controls. In these patients, the sums of T4/T8 cells exceeded that of total T cells, an alteration apparently related to severe liver damage. Cells reacting with antisera to immunoglobulins (B lymphocytes) and to Dr determinants were also within the normal range. In contrast, NK/K (natural killer/killer) cells were increased in the group of patients with steatosis or without liver alteration. Increase of NK/K cells was not observed in patients who were abstinent from alcohol for a period of two weeks or more, suggesting that alcohol may have been responsible for the increase in this lymphocyte population.

journal_name

Dig Dis Sci

authors

Jovanovic R,Worner T,Lieber CS,Paronetto F

doi

10.1007/BF01300696

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

125-30

issue

2

eissn

0163-2116

issn

1573-2568

journal_volume

31

pub_type

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