Familial adenomatous polyposis and extracolonic cancer.

Abstract:

:Our purpose is to focus attention on the cancer family history, coupled with an understanding of the natural history and extracolonic tumor spectrum of familial adenomatous polyposis (FAP), through a family study. This family report provides an example of how colorectal cancer (CRC) can be prevented by knowledgeable gastroenterologists and colorectal surgeons who educate and compassionately counsel members of high-risk families so that their compliance with diagnostic screening and, ultimately, with protection through prophylactic colectomy, is achieved. A working pedigree of this extended family was constructed through interviews with the proband, followed by questionnaires sent to all primary and secondary relatives. Appropriately signed permission forms enabled us to secure pertinent medical and pathology records in order to ensure accuracy of historical information. Integral extracolonic tumors included medulloblastoma, papillary thyroid carcinoma, hepatoblastoma, and desmoid tumors. We conclude that, due in part to improved longevity as a result of being spared CRC, several family members have developed certain FAP integral extracolonic cancers.

journal_name

Dig Dis Sci

authors

Lynch HT,Thorson AG,McComb RD,Franklin BA,Tinley ST,Lynch JF

doi

10.1023/a:1012330626600

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

2325-32

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

46

pub_type

杂志文章
  • Transcatheter embolotherapy for gastrointestinal bleeding: a single center review of safety, efficacy, and clinical outcomes.

    abstract:PURPOSE:The purpose of this study was to assess safety, efficacy, and clinical outcomes following transcatheter arterial embolization (TAE) of acute gastrointestinal (GI) bleeding. MATERIALS AND METHODS:Ninety-five patients (male:female ratio = 53:42, mean age 62 years) that underwent 95 TAEs for GI hemorrhage between...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2547-z

    authors: Yap FY,Omene BO,Patel MN,Yohannan T,Minocha J,Knuttinen MG,Owens CA,Bui JT,Gaba RC

    更新日期:2013-07-01 00:00:00

  • Peroral Endoscopic Myotomy Is a Safe and Feasible Option in Management of Esophageal Diverticula: Systematic Review and Meta-Analysis.

    abstract::Esophageal diverticula can cause significant symptoms and affect the quality of life. There has been recent interest in the use of peroral endoscopic myotomy in the management of esophageal diverticula (D-POEM). In this meta-analysis, we have evaluated the efficacy and safety of D-POEM in the management of esophageal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06678-5

    authors: Kamal F,Khan MA,Lee-Smith W,Sharma S,Marella HK,Iqbal U,Mcdonough S,Aslam A,Ismail MK,Tombazzi C,Adler DG

    更新日期:2020-10-29 00:00:00

  • Comparison of three types of precut technique to achieve common bile duct cannulation: a retrospective analysis of 274 cases.

    abstract:BACKGROUND:The aim of this retrospective study was to evaluate the success rate and complications of three precut techniques of sphincterotomy after failure of conventional techniques of cannulation of common bile duct (CBD). PATIENTS AND METHODS:Between January 2003 and October 2011, 2,903 consecutive ERCPs were perf...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2271-8

    authors: Katsinelos P,Gkagkalis S,Chatzimavroudis G,Beltsis A,Terzoudis S,Zavos C,Gatopoulou A,Lazaraki G,Vasiliadis T,Kountouras J

    更新日期:2012-12-01 00:00:00

  • Experience with the new 4-way, 5.5-mm ultrathin endoscope: a case series.

    abstract:BACKGROUND AND STUDY AIMS:Use of ultrathin (ut) endoscopes is sometimes limited by their design (outer diameter, tip angulation and image quality). New ut-endoscopes are being designed to address these limitations. A new ut-endoscope, XGIF-PV70N5 (Olympus America Inc.), with an outer diameter of 5.5 mm, 4-way angulatio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1344-9

    authors: Agrawal D,Wong RC,Isenberg G,Faulx A,Chak A

    更新日期:2011-03-01 00:00:00

  • Ethanol-mediated neutrophil extravasation in feline pancreas.

    abstract::Ethanol is a common cause of both acute and chronic pancreatitis. Studies in other organs suggest that polymorphonuclear neutrophils activated by ethanol may cause tissue injury in a variety of conditions. The aim of this study was to investigate the effects of ethanol on neutrophil extravasation in the feline pancrea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026634807335

    authors: Reber PU,Lewis MP,Patel AG,Andren-Sandberg A,Ashley SW,Reber HA

    更新日期:1998-12-01 00:00:00

  • Pharmacokinetics of Infliximab and Reduction of Treatment for Inflammatory Bowel Diseases.

    abstract::Local or national policy, patients' preferences, safety and/or economic concerns, or reimbursement issues may dictate stopping drug in inflammatory bowel diseases (IBD) patients. Sustained deep remission is an important predictor of a better outcome after anti-tumor necrosis (TNF) factor therapy discontinuation, inclu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-015-3984-2

    authors: Williet N,Paul S,Peyrin-Biroulet L,Roblin X

    更新日期:2016-04-01 00:00:00

  • The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers: a gastroscopic and photographic study.

    abstract::The effects of various nonsteroidal antiinflammatory drugs on the gastric mucosa were endoscopically evaluated in 40 normal volunteers. Eight groups, each containing five subjects were designed: aspirin (3600 mg/d); placebo; ibuprofen (1600 mg/d); ibuprofen (2400 mg/d); indomethacin (100 mg/d); indomethacin (150 mg/d)...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01324896

    authors: Lanza FL,Royer GL Jr,Nelson RS,Chen TT,Seckman CE,Rack MF

    更新日期:1979-11-01 00:00:00

  • Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease (NAFLD).

    abstract:BACKGROUND:A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). AIMS:To determine if the nutritional intake, intestinal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2112-9

    authors: Volynets V,Küper MA,Strahl S,Maier IB,Spruss A,Wagnerberger S,Königsrainer A,Bischoff SC,Bergheim I

    更新日期:2012-07-01 00:00:00

  • Topical prostaglandin E2 protects isolated gastric mucosa against acidified taurocholate-, but not ethanol- or aspirin-induced injury.

    abstract::This study investigates whether topical prostaglandins protect isolated gastric mucosa against injury provoked by acidified "barrier-breaking" agents. Intracellular pH (pHi), apical cell membrane potential (Vcm) and intraepithelial resistances in isolated Necturus antral mucosa were measured using double-barreled liqu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005465528158

    authors: Ranta-Knuuttila T,Mustonen H,Kivilaakso E

    更新日期:2000-01-01 00:00:00

  • Gut bacterial translocation contributes to microinflammation in experimental uremia.

    abstract:BACKGROUND:Microinflammation frequently develops in chronic uremia with pathological intestinal changes. However, the relationship between gut bacterial translocation and microinflammation in uremia has not been widely investigated. AIM:This study aimed to investigate whether gut microbiome dysbiosis and translocation...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2242-0

    authors: Wang F,Zhang P,Jiang H,Cheng S

    更新日期:2012-11-01 00:00:00

  • Development of an Inflammatory Bowel Disease Research Registry Derived from Observational Electronic Health Record Data for Comprehensive Clinical Phenotyping.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a heterogeneous collection of chronic inflammatory disorders of the digestive tract. Clinical, genetic, and pathological heterogeneity makes it increasingly difficult to translate efficacy studies into real-world practice. Our objective was to develop a comprehensive natur...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4278-z

    authors: Anderson AJ,Click B,Ramos-Rivers C,Babichenko D,Koutroubakis IE,Hartman DJ,Hashash JG,Schwartz M,Swoger J,Barrie AM 3rd,Dunn MA,Regueiro M,Binion DG

    更新日期:2016-11-01 00:00:00

  • Comparison of ultrasound-secretin test and sphincter of Oddi manometry in patients with recurrent acute pancreatitis.

    abstract::Manometry is considered the gold standard for evaluating sphincter of Oddi dysfunction. It has recently been demonstrated that the ultrasound (US) secretin test proposed a few years ago as a noninvasive test for the study of sphincter of Oddi dysfunction yields a substantial percentage of pathological findings in pati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026658618605

    authors: Di Francesco V,Brunori MP,Rigo L,Toouli J,Angelini G,Frulloni L,Bovo P,Filippini M,Vaona B,Talamini G,Cavallini G

    更新日期:1999-02-01 00:00:00

  • Perception of gastric distension. Influence of mode of distension on perception thresholds and gastric compliance.

    abstract::Gastric distension has been used to evaluate gastric sensory function in humans, but the methodology is poorly validated and studies in vivo comparing different distension protocols are lacking. We aimed to compare the influence of the mode of gastric distension on sensation and gastric compliance utilizing a barostat...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02220459

    authors: Holtmann G,Gschossmann J,Guerra G,Goebell H,Talley NJ

    更新日期:1995-12-01 00:00:00

  • Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.

    abstract:BACKGROUND:Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation. AIMS:To study the expression profile of inflammatory and tight junction proteins in the colon f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3428-4

    authors: Lau WL,Liu SM,Pahlevan S,Yuan J,Khazaeli M,Ni Z,Chan JY,Vaziri ND

    更新日期:2015-05-01 00:00:00

  • Low grade esophageal eosinophilia in adults: an unrecognized part of the spectrum of eosinophilic esophagitis?

    abstract:BACKGROUND:Eosinophilic esophagitis (EoE) is defined by a minimum of 15 eosinophils (eos) per high-powered field (HPF) on esophageal biopsy, along with esophageal symptoms and the exclusion of gastroesophageal reflux (GERD). The clinical significance of fewer eosinophils is unknown. METHODS:Fifty-nine adult patients w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1594-1

    authors: Ravi K,Talley NJ,Smyrk TC,Katzka DA,Kryzer L,Romero Y,Arora AS,Alexander JA

    更新日期:2011-07-01 00:00:00

  • Impact of water exchange colonoscopy on serum sodium and potassium levels: an observational study.

    abstract:BACKGROUND:Concerns over the hypothetical adverse effects of water absorption and the disturbance of serum sodium and potassium levels prompted a quality assurance evaluation of water exchange (WE) colonoscopy. AIM:The purpose of this study was to evaluate the balance of water infused and suctioned in WE colonoscopy, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2934-0

    authors: Leung JW,Siao-Salera R,Abramyan O,Mann SK,Ward G,Yen A,Gutierrez R,Leung FW

    更新日期:2014-03-01 00:00:00

  • Geographical Disparities of Outcomes of Hepatocellular Carcinoma in France: The Heavier Burden of Alcohol Compared to Hepatitis C.

    abstract:BACKGROUND:Data on alcohol-related HCC are limited. AIMS:Our aim was to describe the incidence, management, and prognosis of alcohol compared to Hepatitis C (HCV)-related HCC at a national level. METHODS:Incident cases of HCC were identified in French healthcare databases between 2009 and 2012 and analyzed retrospect...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05724-1

    authors: Costentin CE,Sogni P,Falissard B,Barbare JC,Bendersky N,Farges O,Goutte N

    更新日期:2020-01-01 00:00:00

  • Cryptosporidiosis and inflammatory bowel disease. Experience from the Milwaukee outbreak.

    abstract::The 1993 Milwaukee Cryptosporidium outbreak posed several questions regarding appropriate management and prognosis of inflammatory bowel disease patients acutely infected with this organism. We prospectively identified and monitored 12 patients with stable ulcerative colitis or Crohn's disease who suffered abrupt clin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018828507990

    authors: Manthey MW,Ross AB,Soergel KH

    更新日期:1997-08-01 00:00:00

  • Effects of high-fiber diet on fecal blood content (HemoQuant assay) in healthy subjects.

    abstract::Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297143

    authors: Slavin JL,Melcher EA,Sundeen M,Schwartz S

    更新日期:1991-07-01 00:00:00

  • Effects of beta-adrenoceptor stimulation on rectosigmoid motility in man.

    abstract::Effects of selective beta-adrenoceptor agonists on rectosigmoid motility during prolonged rectal distension were studied in 12 healthy volunteers in a double-blind, randomized fashion. Continuous distension was performed with a balloon in the proximal part of the rectum. Pressure was recorded by this balloon and by a ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01320259

    authors: Lyrenäs E,Abrahamsson H,Dotevall G

    更新日期:1985-06-01 00:00:00

  • Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:HAb18G/CD147 expression has been associated with many tumor invasion molecules, which play important roles in recurrence and poor differentiation of esophageal squamous cell carcinoma (ESCC). However, the clinical implications of HAb18G/CD147 in ESCC are still unclear. AIMS:In this study, we clarified the c...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1812-x

    authors: Zhu S,Li Y,Mi L,Zhang Y,Zhang L,Gong L,Han X,Yao L,Lan M,Chen Z,Zhang W

    更新日期:2011-12-01 00:00:00

  • Anemia Severity Associated with Increased Healthcare Utilization and Costs in Inflammatory Bowel Disease.

    abstract:BACKGROUND:Anemia is a common systemic complication of inflammatory bowel disease (IBD) and is associated with worse disease outcomes, quality of life, and higher healthcare costs. AIMS:The purpose of this study was to determine how anemia severity impacts healthcare resource utilization and if treatment of anemia was...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06590-y

    authors: Blaney H,Vu P,Mathew A,Snelling R,England J,Duong C,Hammonds K,Johnson C

    更新日期:2020-09-05 00:00:00

  • A rare gastric outlet anomaly: pyloric ostium on incissura angularis.

    abstract::Congenital gastric outlet anomalies are rarely seen defects resulting from early embryologic development of foregut. We report a case of congenital pyloric outlet anomaly in a 60-year-old man with mild postprandial epigastric discomfort of approximately 3 months' duration. Endoscopic examination of the stomach showed ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9228-8

    authors: Uraz S,Aygün C,Konduk T,Celebi A,Sentürk O,Hülagü S

    更新日期:2007-04-01 00:00:00

  • Effect of omeprazole 40 mg once daily on intraduodenal and intragastric pH in H. pylori-negative healthy subjects.

    abstract::There is a lack of information about the effect of omeprazole or other antisecretory drugs on intraduodenal pH. Aim of the study was to document the variation over time of intraduodenal pH during a 24-hr period and to simultaneously study the effect of omeprazole 40 mg once daily on intragastric and intraduodenal pH i...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1023/a:1018827003641

    authors: Gan KH,Geus WP,Lamers CB,Heijerman HG

    更新日期:1997-11-01 00:00:00

  • Early increase of bone resorption in patients with liver cirrhosis secondary to viral hepatitis.

    abstract::Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone m...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005568406664

    authors: Corazza GR,Trevisani F,Di Stefano M,De Notariis S,Veneto G,Cecchetti L,Minguzzi L,Gasbarrini G,Bernardi M

    更新日期:2000-07-01 00:00:00

  • Spasm of gastric muscularis mucosae might play a key role in causing focal mucosal ischemia and ulceration. An experimental study in guinea pigs.

    abstract::While transilluminating guinea pig gastric wall, we noticed foci of irregular compression of submucosal veins and arteries, featuring parallel bands across arteries, with complete cessation of blood flow, mucosal pallor, and shrinkage of the area. Other features demonstrated that this was not due to artifactual pressu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296065

    authors: Piasecki CK,Thrasivoulou C

    更新日期:1993-07-01 00:00:00

  • Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy.

    abstract::Dermatitis herpetiformis (DH) and isolated gluten-sensitive enteropathy (GSE) are gluten-sensitive diseases in which ingestion of dietary gluten results in the development of clinical disease. Patients with DH develop cutaneous IgA deposits and a severe skin disease, but rarely develop gastrointestinal symptoms. Patie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005512513007

    authors: Hall RP 3rd,Smith AD,Streilein RD

    更新日期:2000-10-01 00:00:00

  • Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner.

    abstract:BACKGROUND:We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. AIMS:The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. METHODS:We searched M...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10620-013-2928-y

    authors: Zhu HC,Yang X,Xu LP,Zhao LJ,Tao GZ,Zhang C,Qin Q,Cai J,Ma JX,Mao WD,Zhang XZ,Cheng HY,Sun XC

    更新日期:2014-03-01 00:00:00

  • The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.

    abstract::This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNM...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-0145-2

    authors: Ding WJ,Fang JY,Chen XY,Peng YS

    更新日期:2008-08-01 00:00:00

  • Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic cholera.

    abstract::The effects of somatostatin on diarrhea and on small intestinal flow of water and electrolytes (slow-marker perfusion technique) in a patient with pancreatic cholera are reported. Continuous intravenous infusion of somatostatin (8 micrograms/kg/hr) suppressed the diarrhea, but a rebound was observed after somatostatin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295657

    authors: Ruskoné A,René E,Chayvialle JA,Bonin N,Pignal F,Kremer M,Bonfils S,Rambaud JC

    更新日期:1982-05-01 00:00:00