Effect of combination of montelukast and levocetirizine on otitis media with effusion: a prospective, placebo-controlled trial.

Abstract:

CONCLUSION:This study demonstrated that treatment with montelukast in combination with levocetirizine may have a beneficial effect on clinical improvement of middle ear fluid in children with otitis media with effusion (OME). OBJECTIVE:To evaluate the effect of the combination of montelukast and levocetirizine on shortening the duration of effusion in successfully treated OME in children. METHODS:This was a randomized, prospective, double-blind, placebo-controlled trial. The study group consisted of 120 children (age range 2-6 years), who were diagnosed with OME of at least 2 months duration. The children were randomized into one of four groups. The treatment packs containing montelukast 4 mg (tablet) and/or levocetirizine 2.5 mg/5 ml as the active drug or placebo were prepared, numbered, and distributed by the second author. RESULTS:The amelioration of bilateral otoscopic sign scores in the combination therapy group was statistically significantly greater than in all the other groups (p < 0.05). Improvement in bilateral tympanometric findings in the combination therapy group and montelukast group was greater than in the other groups. However, this difference was not statistically significant (p > 0.05). When we compared the difference between otoscopic sign scores before and after treatment we found that it was statistically significant in every group (p > 0.05). However, the significant improvement in tympanometric findings occurred in all groups except the levocetirizine group (p > 0.05).

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Ertugay CK,Cingi C,Yaz A,San T,Ulusoy S,Erdogmus N,Ertugay OC

doi

10.3109/00016489.2013.824113

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1266-72

issue

12

eissn

0001-6489

issn

1651-2251

journal_volume

133

pub_type

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