Abstract:
:In this study I attempted to assess, in rats, the role of AT1 and AT2 angiotensin receptor subtypes in the phenomenon of improved learning and memory after an intracerebroventricular (icv) injection of angiotensin II (Ang II) and Ang II (3-7). Selective AT1 (losartan, 1 mg) or AT2 (CGP 42112 A, 2 micrograms) receptor antagonist was dissolved in 2 microliters of saline and given to the left cerebral ventricle 5 min before 1 nmol Ang II or Ang II (3-7) injected in the same volume of saline to the right ventricle. Consequently, there were 9 experimental groups which underwent 3 memory oriented and 3 auxiliary tests. Ang II and Ang II (3-7) significantly improved retention of the passive avoidance and recognition memory. These effects were abolished by losartan or CGP 42112 A. Better, after Ang II and Ang II (3-7), acquisition of conditioned avoidance responses was unchanged by losartan and abolished by CGP 42112 A. None of the treatments significantly changed rats motor behaviour in open field. Losartan as well as CGP 42112 A abolished significant enhancement of apomorphine (1 mg/kg, i.p.) stereotypy caused by Ang II and Ang II (3-7). The results suggest considerable involvement of AT1 and AT2 angiotensin receptors in the cognitive enhancement produced by angiotensins.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Braszko Jsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
49-54issue
1eissn
0065-1400issn
1689-0035journal_volume
56pub_type
杂志文章abstract::Sham operated controls and four groups of rats subjected to ablation of various parts of their frontal cortex were compared in food and water intake and four behavioural tasks. The ablations were aimed at removing (1) the ventral prefrontal cortex, (2) the dorsal part of the medial prefrontal cortex, (3) the total med...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
abstract::The interaction between kinins formed in central nervous system and acetylcholine was studied. Endogenous ACh in excess acted psychodepressively on the animal's behavior as evaluated with Lat's test. This effect was more intense in those rats in which the activity of kinin-forming enzymes in the nervous tissue had bee...
journal_title:Acta neurobiologiae experimentalis
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abstract::Proprioceptive effects (PE) on directional hearing, i.e., sound image shifts relatively to the sound source, produced by changes in head position, were studied in their dependence on head movement type in two groups of listeners. The first group included subjects in whom horizontal head deviation to the right or to th...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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abstract::Embedment-free electron microscopy (EFEM) is a new method which allows the visualisation of cytoskeleton in whole-mounted cells. In this study we employed EFEM to investigate the structure of cellular scaffolds in glioma C6 cell line. The cells were extracted with Triton X-100 that dissolves phospholipids in the membr...
journal_title:Acta neurobiologiae experimentalis
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:10.21307/ane-2017-012
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1972-01-01 00:00:00
abstract::The pedunculopontine tegmental nucleus (PPN) is one of the reticular generators of the hippocampal theta rhythm. The PPN neuronal circuitry related to theta generation involves its cholinergic, GABA-ergic and glutamatergic components. Here we provide data indicating that the PPN tachykinin system may also be a part of...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This mini review gives a brief overview over the oxidation mechanism of methionine (Met), relevant for processes which may lead to the oxidation of amyloid beta-peptide (betaAP), involved in the pathogenesis of Alzheimer's disease. The Cu(II) -catalysed oxidation of C-terminal Met35 in betaAP depends on the secondary ...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::Adult, male, Long-Evans hooded rats were subjected to a spinal cord transection in the mid-thoracic region. Following surgery, animals were divided into groups for treatments with ACTH, Piromen, isobutyl-2-cyanoacrylate and Cytoxan. Animals were sacrificed at varying intervals from 7-180 days. Horizontal sections of t...
journal_title:Acta neurobiologiae experimentalis
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更新日期:1980-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
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doi:
更新日期:1991-01-01 00:00:00
abstract::A term "paralytic tremor" (pt) is attributed to a neurological mutation of Chinchilla rabbits, affecting the development of the central nervous system (CNS). A quantification of myelin protein content indicates the strong CNS hypomyelination during the development (1-120 postnatal days). SDS-PAGE electrophoresis of to...
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pub_type: 杂志文章
doi:
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1974-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Anxiety disorders are a social problem due to their prevalence and consequences. It is crucial to explore the influence of anxiety on cognitive processes. In this study we recorded EEG activity from 73 subjects (35 patients, 38 controls, matched for age and education) during performance of the Continuous Attention Tas...
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pub_type: 杂志文章
doi:10.21307/ane-2017-007
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journal_title:Acta neurobiologiae experimentalis
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doi:
更新日期:1994-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2018-01-01 00:00:00
abstract::A new hypothesis concerning the mechanism of the P. rufescens' slave-raids, is proposed. (i) The so-called pseudo-scouting does not contribute to the slave-raids. (ii) The direction of the raid is determined by the random movement of the most easily aroused individuals - the so-called activists. (iii) Once the directi...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::During the normal course of neuronal differentiation gangliosides undergo marked changes in both quantity and quality. These changes, i.e. several-fold increase in concentration and appearance of the gangliotetraose family, have been observed both in vivo and in neuronal cell cultures. In addition to these naturally o...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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doi:
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