Abstract:
:During the normal course of neuronal differentiation gangliosides undergo marked changes in both quantity and quality. These changes, i.e. several-fold increase in concentration and appearance of the gangliotetraose family, have been observed both in vivo and in neuronal cell cultures. In addition to these naturally occurring (endogenous) manifestations, exogenously administered gangliosides have been observed to exert neuritogenic and/or neuronotrophic effects on a variety of neuroblastoma cell lines and primary neuronal culture systems. Unlike the endogenous effects, which appear to require gangliotetraose structures, the structural specificity of the exogenous effect is quite broad. Thus, all of 11 different gangliosides proved neuritogenic with neuro-2A neuroblastoma cells. Furthermore, synthetic sialoglycolipids possessing a beta-ketosidic sialic acid linkage and/or a glyceride-like moiety in place of ceramide all caused enhanced neurite outgrowth in neuro-2A, PC12, and embryonic chick dorsal root ganglia. A derivative of GM1 lacking the negative charge was also active in the same 3 systems. These results point to general perturbation of the membrane, probably a physical-chemical effect, in a manner which triggers intracellular events leading to differentiation. In contrast to these in vitro results, use of the above GM1 derivative in two in vivo models proved ineffective in maintaining the level of cholinergic markers that were preserved by GM1 in lesioned brains. These results point to fundamentally different mechanism for the trophic effects of administered gangliosides in vivo and in vitro.
journal_name
Acta Neurobiol Exp (Wars)journal_title
Acta neurobiologiae experimentalisauthors
Ledeen RW,Wu G,Cannella MS,Oderfeld-Nowak B,Cuello ACsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
439-49issue
4-5eissn
0065-1400issn
1689-0035journal_volume
50pub_type
杂志文章,评审abstract::In four dogs instrumental defensive conditioned reflexes to direct electrical stimulation of the hippocampus were elaborated. After reaching 60 percent CR performance, unreinforced stimulations of several limbic structures were given to test generalization. Positive generalization was more frequent than negative one. ...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Transcranial magnetic stimulation was carried out in 30 healthy subjects, aged 20 to 55 and 156 to 180 cm tall, in whom cortical excitability threshold was determined for musculus (m.) abductor digiti minimi (ADM) and m. extensor digitorum brevis (EDB). The lowest stimulus intensity causing in the muscle a reproducibl...
journal_title:Acta neurobiologiae experimentalis
pub_type: 临床试验,杂志文章
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abstract::In the present communication, a possible role of perceptual displacements of stimulus elements in the occurrence of visual illusions of extent has been considered. In psychophysical experiments with a single set of Müller-Lyer wings, subjects were asked to place an imaginary reference rectangle into a position that ma...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::A modified method of injection into the cerebellomedullary (CM) cistern of mice was developed based on fixation of the mouse with a special mask under inhalation anesthesia, and exposure of the sagittal suture of the cranium and midline of the nape to allow us to visualize injection point directly. The accuracy of the...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Neuron transplantation is considered to be a promising therapeutic method to replace functions lost due to central nervous system (CNS) damage. However, little is known about the extent to which implanted neuron-like cells can develop into mature neurons and acquire essential properties, and especially formation of sy...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::The objective of this study was to verify hypothesised changes in event related potentials (visual mismatch negativity, vMMN) in 17 subjects dependent on methamphetamine (MAMP) compared to age and gender matched 17 healthy volunteers. We found a significant correlation between vMMN and duration of methamphetamine abus...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::New multichannel descriptors of EEG activity: complexity (omega), total power (zeta) and generalized frequency (phi) were applied to whole night sleep analysis in 11 healthy subjects. The values of omega and phi decreased systematically from waking to slow wave sleep, and increased systematically in consecutive NREM-R...
journal_title:Acta neurobiologiae experimentalis
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::We used 5 binocularly deprived cats (BD cats), 4 control cats reared also in the laboratory (C cats) and 4 cats reared in a normal environment (N cats). The cats were trained to discriminate an upward or downward-moving light spot versus a stationary spot (detection task) and then an upward versus a downward spot (dir...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Trimethyltin, an organic compound of tin, is a potent neurotoxicant of a mechanism of action yet to be uncovered. The neuropathological findings that trimethyltin causes selective hippocampal damage with several unique features, highly reminiscent of Ammon's horn sclerosis as a final result, have raised the possibilit...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::The intergeniculate leaflet (IGL) of the thalamus constitutes a small but important part of the neural network controlling circadian activity in rodents. It appears that IGL integrates photic cues from retina with non-photic information originating from different nonspecific brain systems. Subsequently, this integrate...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated....
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2019-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:10.21307/ane-2017-040
更新日期:2017-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2020-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::This study aimed to provide a simple way to approach group differences by independent component analysis when researching functional connectivity changes of resting-state network in brain disorders. We used baseline resting state functional magnetic resonance imaging from the Alzheimer's disease neuroimaging initiativ...
journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:10.21307/ane-2017-028
更新日期:2016-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:10.21307/ane-2017-048
更新日期:2017-01-01 00:00:00
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journal_title:Acta neurobiologiae experimentalis
pub_type: 杂志文章
doi:
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