Thalamocortical connectivity during resting state in schizophrenia.

Abstract:

:Schizophrenia has been linked to disturbed connectivity between large-scale brain networks. Altered thalamocortical connectivity might be a major mechanism mediating regionally distributed dysfunction, yet it is only incompletely understood. We analysed functional magnetic resonance imaging data obtained during resting state from 22 DSM-IV schizophrenia patients and 22 matched healthy controls to directly assess the differences in thalamocortical functional connectivity. We identified significantly higher overall thalamocortical functional connectivity in patients, which was mostly accounted for by difference in thalamic connections to right ventrolateral prefrontal and bilateral secondary motor and sensory (superior temporal and lateral occipital) cortical areas. Voxelwise analysis showed group differences at the thalamic level to be mostly in medial and anterior thalamic nuclei and arising thalamocortical changes to be mostly due to higher positive correlations in prefrontal and superior temporal correlations, as well as absent negative correlations to sensory areas in patients. Our findings demonstrate that different types of thalamocortical dysfunction contribute to network alterations, including lack of inhibitory interaction attributed to the lack of significant negative thalamic/sensory cortical connections. These results emphasize the functional importance of the thalamus in the pathophysiology of schizophrenia.

authors

Klingner CM,Langbein K,Dietzek M,Smesny S,Witte OW,Sauer H,Nenadic I

doi

10.1007/s00406-013-0417-0

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

111-9

issue

2

eissn

0940-1334

issn

1433-8491

journal_volume

264

pub_type

杂志文章
  • Obsessional personality features in employed Japanese adults with a lifetime history of depression: assessment by the Munich Personality Test (MPT).

    abstract:BACKGROUND:Although a number of studies have reported on the association between obsessional personality features as measured by the Munich Personality Test (MPT) "Rigidity" scale and depression, there has been no examination of these relationships in a non-clinical sample. METHODS:The dimensional scores on the MPT we...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060170043

    authors: Sakado K,Sakado M,Seki T,Kuwabara H,Kojima M,Sato T,Someya T

    更新日期:2001-06-01 00:00:00

  • Premenstrual dysphoric symptoms amongst Brazilian college students: factor structure and methodological appraisal.

    abstract:OBJECTIVES:The present study aims to assess the factor structure of the DSM-IV Premenstrual Dysphoric Disorder (PMDD) symptoms and its relationship with depressive symptoms. METHODS:We evaluated retrospectively PMDD symptoms in 513 female college students, through a self-reporting questionnaire based on DSM-IV criteri...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0535-9

    authors: Teng CT,Filho AH,Artes R,Gorenstein C,Andrade LH,Wang YP

    更新日期:2005-02-01 00:00:00

  • Obstetric complications and neurological abnormalities in neuroleptic-naive psychotic patients.

    abstract::Studies addressing the relationship between a history of obstetric complications (OCs) and neurological abnormalities in schizophrenia have produced contradictory findings. Using a pre-posttreatment design in a neuroleptic-naive sample of psychotic patients, we examined the relationship of a history of OC to primary a...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-006-0653-7

    authors: Peralta V,Cuesta MJ,Serrano JF

    更新日期:2006-10-01 00:00:00

  • Seizure threshold increases can be predicted by EEG quality in right unilateral ultrabrief ECT.

    abstract::Increases in seizure threshold (ST) over a course of brief pulse ECT can be predicted by decreases in EEG quality, informing ECT dose adjustment to maintain adequate supra-threshold dosing. ST increases also occur over a course of right unilateral ultrabrief (RUL UB) ECT, but no data exist on the relationship between ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00406-017-0777-y

    authors: Gálvez V,Hadzi-Pavlovic D,Waite S,Loo CK

    更新日期:2017-12-01 00:00:00

  • Repeated bullying at the workplace in medical students and young doctors: the MESSIAEN national study.

    abstract::Despite clues indicating high Bullying at the Work Place (BWP) rates in French hospitals, there has been no quantitative study so far. To determine the prevalence of repeated BWP in a national sample of French young physicians; its risk factors, and the mental health consequences of BWP. The study is a cross-sectional...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01144-9

    authors: Messiaen M,Duba A,Boulangeat C,Boucekine M,Bourbon A,Viprey M,Auquier P,Lançon C,Boyer L,Fond G

    更新日期:2020-05-27 00:00:00

  • Prevention of rehospitalization in schizophrenia: results of an integrated care project in Germany.

    abstract::The goal of this study was to prevent rehospitalizations and thus to optimize satisfaction with treatment and quality of life in patients suffering by schizophrenia or schizoaffective disorder. A complex intervention with improved cooperation between in- and outpatient services was applied to 46 "high utilizing" patie...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00406-009-0056-7

    authors: Schmidt-Kraepelin C,Janssen B,Gaebel W

    更新日期:2009-11-01 00:00:00

  • Early-onset Alzheimer's disease due to mutations of the presenilin-1 gene on chromosome 14: a 7-year follow-up of a patient with a mutation at codon 139.

    abstract::Mutations in the presenilin-1 gene (PS-1 gene) on chromosome 14 have recently been identified as a cause of familial early-onset Alzheimer's disease (EOAD). To our knowledge, only two German EOAD patients with mutations in the PS-1 gene have been identified thus far. Herein we report the case of a German EOAD patient ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060050028

    authors: Hüll M,Fiebich BL,Dykierek P,Schmidtke K,Nitzsche E,Orszagh M,Deuschl G,Moser E,Schumacher M,Lücking C,Berger M,Bauer J

    更新日期:1998-01-01 00:00:00

  • Event-related potential P300 microstate topography during visual one- and two-dimensional tasks in chronic schizophrenics.

    abstract::Reports on left-lateralized abnormalities of component P300 of event-related brain potentials (ERP) in schizophrenics typically did not vary task difficulties. We collected 16-channel ERP in 13 chronic, medicated schizophrenics (25 +/- 4.9 years) and 13 matched controls in a visual P300 paradigm with targets defined b...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02189021

    authors: Kochi K,Koenig T,Strik WK,Lehmann D

    更新日期:1996-01-01 00:00:00

  • Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD.

    abstract:OBJECTIVE:Several predictors of Alzheimer's disease (AD) have been identified. However, the relevance and independent contribution of risk factors and of possible early signs such as mild cognitive impairment and subjective memory impairment on the development of AD has not been investigated prospectively in a cohort o...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-005-0596-4

    authors: Heun R,Kölsch H,Jessen F

    更新日期:2006-02-01 00:00:00

  • Interinformant reliability of family history information on psychiatric disorders in relatives.

    abstract::Knowledge on the reliability of family history information is essential for every family study. However, systematic analyses of interinformant reliability of family history information on individual relatives have not yet been published. Consequently, family history information on 1306 first-degree relatives and spous...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060050025

    authors: Heun R,Müller H

    更新日期:1998-01-01 00:00:00

  • Nocturnal sleep EEG in patients with HIV infection.

    abstract::Nocturnal sleep was studied in 14 human immunodeficiency virus (HIV)-positive patients without opportunistic infections of the central nervous system. Seven patients had no bodily complaints at the time of the investigation. Patients exhibited an impaired nocturnal sleep with longer sleep onset latency, reduced total ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02190756

    authors: Wiegand M,Möller AA,Schreiber W,Krieg JC,Fuchs D,Wachter H,Holsboer F

    更新日期:1991-01-01 00:00:00

  • Postural imbalance: an early sign in HIV-1 infected patients.

    abstract::We have recorded postural performance in 50 HIV-infected patients in different stages of the disease (Walter Reed (WR) stages I-VI) by means of a force measuring platform. The results were compared with 50 age-matched controls. A significant instability was particularly evident when standing on an unstable foot suppor...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02195975

    authors: Trenkwalder C,Straube A,Paulus W,Krafczyk S,Schielke E,Einhäupl KM

    更新日期:1992-01-01 00:00:00

  • Twin-based study of the complex interplay between childhood maltreatment, socioeconomic status and adult memory.

    abstract::Childhood maltreatment and low socioeconomic status (SES) are considered stressful environmental events with lasting detrimental effects on adult mental health and associated cognitive performance, such as memory. However, the association between childhood maltreatment and low SES remains unclear, probably due to desi...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-012-0382-z

    authors: Goldberg X,Alemany S,Fatjó-Vilas M,González-Ortega I,González-Pinto A,Cuesta MJ,Fañanás L

    更新日期:2013-08-01 00:00:00

  • Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex.

    abstract::Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in social cognition. We hypothesize that oxytocin, a neuropeptide with an important role in social behaviour, can effectively alter the connectivity of the DMN. We test...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-00989-z

    authors: Kumar J,Iwabuchi SJ,Völlm BA,Palaniyappan L

    更新日期:2020-08-01 00:00:00

  • Moclobemide and fluoxetine for panic disorder. International Panic Disorder Study Group.

    abstract::An international, multicentre, double blind parallel group study compared the tolerability and efficacy of moclobemide with the selective serotonin reuptake inhibitor (SSRI) fluoxetine for panic disorder. SSRIs have been shown effective for panic. The target dose of moclobemide was 450 mg and of fluoxetine was 20 mg. ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/pl00014164

    authors: Tiller JW,Bouwer C,Behnke K

    更新日期:1999-01-01 00:00:00

  • Seasonality of suicide attempts: association with gender.

    abstract::Some studies suggest seasonality of suicide attempts in females, but not in males. The reasons for this gender difference remain unclear. Only few studies addressed the question whether gender differences in seasonality of suicide attempts reflect gender differences in the choice of method for suicide attempts, with i...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-009-0086-1

    authors: Mergl R,Havers I,Althaus D,Rihmer Z,Schmidtke A,Lehfeld H,Niklewski G,Hegerl U

    更新日期:2010-08-01 00:00:00

  • Attention as neurocognitive endophenotype of ADHD across the life span: a family study.

    abstract::Endophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes is an important step to unravel disease pathways underlying complex psychiatric phenotypes such as ADHD. Potential viable endophenotypes for ADHD ac...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-00993-3

    authors: Boxhoorn S,Lopez E,Schmidt C,Schulze D,Hänig S,Cholemkery H,Freitag CM

    更新日期:2019-09-01 00:00:00

  • Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia.

    abstract::Event-related potentials (ERPs) can serve as markers for cognitive processing stages. Identification of those ERPs altered in schizophrenia offer information about cognitive dysfunction. Auditory evoked potentials (AEPs) were elicited within an oddball paradigm in 35 schizophrenic patients and compared with 35 healthy...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004060050055

    authors: Frodl T,Meisenzahl EM,Gallinat J,Hegerl U,Möller HJ

    更新日期:1998-01-01 00:00:00

  • "A stitch in time" ... the scope for preventive strategies in early psychosis.

    abstract::Preventive endeavours in psychotic disorders have been hampered by many obstacles over the past century. One important barrier has been the corrosive pessimism which has attached to the treatment prospects for schizophrenia in particular since the time of Kraepelin, and the isolation of this disorder from progressive ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s004060050014

    authors: McGorry PD

    更新日期:1998-01-01 00:00:00

  • Brain perfusion asymmetry in patients with oral somatic delusions.

    abstract::Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. W...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0390-7

    authors: Umezaki Y,Katagiri A,Watanabe M,Takenoshita M,Sakuma T,Sako E,Sato Y,Toriihara A,Uezato A,Shibuya H,Nishikawa T,Motomura H,Toyofuku A

    更新日期:2013-06-01 00:00:00

  • Cognitive predictors of skill acquisition on social problem solving in patients with schizophrenia.

    abstract::The aim of the study was to evaluate the relationship between social problem solving ability, clinical features and cognitive functions, and determine the predictors of benefit from social problem solving training in 63 patients with schizophrenia. We administered Brief Psychiatric Rating Scale (BPRS), Wisconsin Card ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00406-006-0651-9

    authors: Uçok A,Cakir S,Duman ZC,Dişcigil A,Kandemir P,Atli H

    更新日期:2006-09-01 00:00:00

  • Sleep homeostasis in alcohol-dependent, depressed and healthy control men.

    abstract::Visually scored and power spectral analyses (PSA) of polysomnography (PSG) recordings reveal abnormalities in alcohol dependence (AD) and major depressive disorder (MDD), including deficiencies in slow wave activity (SWA) during non-rapid eye movement (NREM) sleep. SWA parameters reflect the integrity of the homeostat...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-011-0195-5

    authors: Brower KJ,Hoffmann R,Conroy DA,Arnedt JT,Armitage R

    更新日期:2011-12-01 00:00:00

  • Fluoxetine once every third day in the treatment of major depressive disorder.

    abstract:OBJECTIVE:Fluoxetine and its active metabolite norfluoxetine have long half-lives. We postulate that, owing to the long elimination half-life and the time to reach steady-state level in plasma is nearly four weeks, patients diagnosed with major depressive disorder might be treated with fluoxetine taken once every third...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00406-003-0445-2

    authors: Tural U,Onder E

    更新日期:2003-12-01 00:00:00

  • Prevalence of affective disorders and dementia in inflammatory polyarthropathies.

    abstract::Comorbid disorders are common in psychiatric diseases and understanding the risk of secondary diseases can aid successful clinical treatment. The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German H...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-01015-y

    authors: Vogelgsang J,Heßmann P,Wolff-Menzler C,Gyßer S,Müller GA,Wiltfang J

    更新日期:2020-03-01 00:00:00

  • Classical conditioning in borderline personality disorder: an fMRI study.

    abstract::Previous research suggests disturbed emotional learning and memory in borderline personality disorder (BPD). Studies investigating the neural correlates of aversive differential delay conditioning in BPD are currently lacking. We aimed to investigate acquisition, within-session extinction, between-session extinction r...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-015-0593-1

    authors: Krause-Utz A,Keibel-Mauchnik J,Ebner-Priemer U,Bohus M,Schmahl C

    更新日期:2016-06-01 00:00:00

  • Cerebral blood flow responses during prosaccade and antisaccade preparation in major depression.

    abstract::While impairments in executive functions have been well established in major depressive disorder (MDD), specific deficits in proactive control have scarcely been studied so far. Proactive control refers to cognitive processes during anticipation of a behaviorally relevant event that facilitate readiness to react. In t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0956-5

    authors: Hoffmann A,Ettinger U,Montoro C,Reyes Del Paso GA,Duschek S

    更新日期:2019-10-01 00:00:00

  • Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia.

    abstract::Obstetric complications play a role in the pathophysiology of schizophrenia. However, the biological consequences during neurodevelopment until adulthood are unknown. Microarrays have been used for expression profiling in four brain regions of a rat model of neonatal hypoxia as a common factor of obstetric complicatio...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-010-0159-1

    authors: Sommer JU,Schmitt A,Heck M,Schaeffer EL,Fendt M,Zink M,Nieselt K,Symons S,Petroianu G,Lex A,Herrera-Marschitz M,Spanagel R,Falkai P,Gebicke-Haerter PJ

    更新日期:2010-11-01 00:00:00

  • Human CLOCK gene-associated attention deficit hyperactivity disorder-related features in healthy adults: quantitative association study using Wender Utah Rating Scale.

    abstract::Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0443-y

    authors: Jeong SH,Yu JC,Lee CH,Choi KS,Choi JE,Kim SH,Joo EJ

    更新日期:2014-02-01 00:00:00

  • The concept of major depression. I. Descriptive comparison of six competing operational definitions including ICD-10 and DSM-III-R.

    abstract::All operationalized diagnostic systems contain a diagnostic category, which corresponds to the concept of major depression. Yet, these corresponding definitions are not identical. Up to now, no comprehensive comparisons of the competing diagnoses have been published. We will therefore present a series of studies, desc...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/BF02189537

    authors: Philipp M,Maier W,Delmo CD

    更新日期:1991-01-01 00:00:00

  • Evidence for separate diseases?: Stages of one disease or different combinations of symptom dimensions?

    abstract:OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-008-2011-4

    authors: Häfner H,an der Heiden W,Maurer K

    更新日期:2008-06-01 00:00:00