Abstract:
:Complex traits have been modeled under various modes of two-locus inheritance. One example of a two-locus threshold model is the situation where an individual is susceptible to a disease trait if he or she carries three or more disease alleles. Under this model, if each locus is examined individually the inheritance appears recessive for some mating types and dominant for others. We developed a heterogeneity test, the Model-heterogeneity test, where an admixture of dominant and recessive sibships can be present. The properties of the Model-heterogeneity test were examined and compared to the Admixture test. The power of the Model-heterogeneity test to detect linkage is comparable to that of the Admixture test.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Leal SM,Ott Jdoi
10.1002/(SICI)1098-2272(1997)14:6<1097::AID-GEPI89subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1097-100issue
6eissn
0741-0395issn
1098-2272pii
10.1002/(SICI)1098-2272(1997)14:6<1097::AID-GEPI89journal_volume
14pub_type
临床试验,杂志文章,随机对照试验abstract::The study of the genetic component of early-onset diseases requires investigation into parental genetic effects, particularly those mediated by the mother who can influence the offspring's risk of disease through the effects of her genes acting directly on the intrauterine milieu or indirectly through maternal-gene ch...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20602
更新日期:2011-09-01 00:00:00
abstract::High-throughput sequencing technologies have enabled large-scale studies of the role of the human microbiome in health conditions and diseases. Microbial community level association test, as a critical step to establish the connection between overall microbiome composition and an outcome of interest, has now been rout...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.22030
更新日期:2017-04-01 00:00:00
abstract::Several approaches were taken to identify the loci contributing to the quantitative and qualitative phenotypes in the Genetic Analysis Workshop 12 simulated data set. To identify possible quantitative trait loci (QTL), the quantitative traits were analyzed using SOLAR. The four replicates identified as the "best repli...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s732
更新日期:2001-01-01 00:00:00
abstract::We determined pairwise linkage disequilibria between 12 restriction fragment length polymorphism (RFLP) markers at or near the low-density lipoprotein receptor (LDLR) locus on chromosome 19p13.2-13.1 in 92 unrelated individuals. Of these 12 RFLPs, two were newly identified under a cosmid-based strategy designed to scr...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370070114
更新日期:1990-01-01 00:00:00
abstract::Three characteristics of genetic epidemiology that distinguish it from its parent disciplines are a focus on population-based research, a focus on the joint effects of genes and the environment, and the incorporation of the underlying biology of the disease into its conceptual models. These principles are illustrated ...
journal_title:Genetic epidemiology
pub_type:
doi:10.1002/1098-2272(200012)19:4<289::AID-GEPI2>3.0.C
更新日期:2000-12-01 00:00:00
abstract::In the past decade, many genome-wide association studies (GWASs) have been conducted to explore association of single nucleotide polymorphisms (SNPs) with complex diseases using a case-control design. These GWASs not only collect information on the disease status (primary phenotype, D) and the SNPs (genotypes, X), but...
journal_title:Genetic epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1002/gepi.22045
更新日期:2017-07-01 00:00:00
abstract::We investigated a variety of methods for pooling data from eight data sets (n = 5,424 subjects) to validate evidence for linkage of markers in the cytokine cluster on chromosome 5q31-33 to asthma and asthma-associated phenotypes. Chromosome 5 markers were integrated into current genetic linkage and physical maps, and ...
journal_title:Genetic epidemiology
pub_type: 杂志文章,meta分析
doi:10.1002/gepi.2001.21.s1.s103
更新日期:2001-01-01 00:00:00
abstract::Intended to resolve the problem of constructing a matched population-based control sample, haplotype relative risk techniques frequently suffer from loss of power for late-onset diseases due to unavailability of parental genotypes that are required to form parent-offspring pairs. However, much of this missing informat...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1998)15:5<471::AID-GEPI3>3
更新日期:1998-01-01 00:00:00
abstract::Sub-Saharan Africa has been identified as the part of the world with the greatest human genetic diversity. This high level of diversity causes difficulties for genome-wide association (GWA) studies in African populations-for example, by reducing the accuracy of genotype imputation in African populations compared to no...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20626
更新日期:2011-12-01 00:00:00
abstract::Twin pairs are sometimes included in studies because at least one of them is a proband, and conventionally the analysis of the data is based on the conditional distribution of the co twin given the proband. In the case of more than one proband in each pair, an often used "ad hoc" method of analysis is to allow each tw...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.10253
更新日期:2003-11-01 00:00:00
abstract::Population isolates may be particularly useful for association studies of complex traits. This utility, however, largely depends on the transferability of tag SNPs chosen from reference samples, such as HapMap, to samples from such populations. Factors that characterize population isolates, such as widespread genetic ...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20201
更新日期:2007-04-01 00:00:00
abstract::Our group studied the effects of genotyping errors, pedigree errors, and missing data on a wide range of techniques, with a focus on the role of single-nucleotide polymorphisms (SNPs). Half of our group used simulated data, and half of our group used data from the Collaborative Study on the Genetics of Alcoholism (COG...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20120
更新日期:2005-01-01 00:00:00
abstract::We combined the five chromosome 18 bipolar affective disorder data sets provided by GAW10, totaling 185 families with 3,394 individuals, and performed analysis of differential parental transmission and chromosome 18 marker allele sharing in families with transmission through fathers vs those through mothers. Results i...
journal_title:Genetic epidemiology
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1098-2272(1997)14:6<665::AID-GEPI19>
更新日期:1997-01-01 00:00:00
abstract::By analyzing more next-generation sequencing data, researchers have affirmed that rare genetic variants are widespread among populations and likely play an important role in complex phenotypes. Recently, a handful of statistical models have been developed to analyze rare variant (RV) association in different study des...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21804
更新日期:2014-05-01 00:00:00
abstract::There has been extensive literature on modeling gene-gene interaction (GGI) and gene-environment interaction (GEI) in case-control studies with limited literature on statistical methods for GGI and GEI in longitudinal cohort studies. We borrow ideas from the classical two-way analysis of variance literature to address...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.21744
更新日期:2013-09-01 00:00:00
abstract::We performed multivariate genetic analyses of cardiovascular risk factors from two sets of data on US and Australian female twins. Similar models for body mass index (BMI), serum low density (LDL) and high density (HDL) lipoproteins, including age as a covariate, were fitted successfully to both groups. These suggeste...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370100638
更新日期:1993-01-01 00:00:00
abstract::The recent successes of genome-wide association studies (GWAS) have renewed interest in genome environment wide interaction studies (GEWIS) to discover genetic factors that modulate penetrance of environmental exposures to human diseases. Indeed, gene-environment interactions (G × E), which have not been emphasized in...
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pub_type: 杂志文章
doi:10.1002/gepi.21890
更新日期:2015-07-01 00:00:00
abstract::Linkage disequilibrium mapping of quantitative traits is a powerful method for dissecting the genetic etiology of complex phenotypes. Quantitative traits, however, often exhibit characteristics that make their use problematic. For example, the distribution of the trait may be censored, highly skewed, or contaminated w...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20141
更新日期:2006-04-01 00:00:00
abstract::This study is an investigation of the relationship between apolipoprotein E (apoE) phenotype, arterial disease, and mortality in a group of women (n = 1,751) aged 65 years and older enrolled in the Study of Osteoporotic Fractures. Crude mortality rates were highest among women with the 4-3 and 4-4 phenotypes but age-a...
journal_title:Genetic epidemiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/(SICI)1098-2272(1997)14:2<147::AID-GEPI4>3
更新日期:1997-01-01 00:00:00
abstract::The Framingham Heart Study data, as well as a related simulated data set, were generously provided to the participants of the Genetic Analysis Workshop 13 in order that newly developed and emerging statistical methodologies could be tested on that well-characterized data set. The impetus driving the development of nov...
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pub_type: 杂志文章
doi:10.1002/gepi.10285
更新日期:2003-01-01 00:00:00
abstract::Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identity-by-decent) from affected sib pairs. This is carried out by conditionin...
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pub_type: 杂志文章
doi:10.1002/gepi.10305
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.1370020103
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.22083
更新日期:2017-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s467
更新日期:2001-01-01 00:00:00
abstract::The complex etiology of common diseases like cardiovascular disease, diabetes, hypertension, and rheumatoid arthritis has led investigators to focus on the genetics of correlated phenotypes and risk factors. Joint analysis of multiple disease-related phenotypes may reveal genes of pleiotropic effect and increase analy...
journal_title:Genetic epidemiology
pub_type:
doi:10.1002/gepi.20470
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章,评审
doi:10.1002/gepi.20285
更新日期:2007-01-01 00:00:00
abstract::Artificial neural networks were applied to the alcoholism data to reveal nonlinear relationships between intermediate phenotypes, marker identity-by-descent sharing, and the affection status. A variable number of hidden units were considered to achieve a balance between the minimal mean-squared error and over-fitting ...
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pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.1370170748
更新日期:1999-01-01 00:00:00
abstract::Understanding the genetic background of complex diseases and disorders plays an essential role in the promising precision medicine. The evaluation of candidate genes, however, requires time-consuming and expensive experiments given a large number of possibilities. Thus, computational methods have seen increasing appli...
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更新日期:2020-06-01 00:00:00