Abstract:
:A robust approach for estimating standard errors of variance components by using quantitative phenotypes from families ascertained through a proband with an extreme phenotypic value is presented. Estimators that use the multivariate normal distribution as a "working likelihood" are obtained by computing conditional ln-likelihoods, conditional first and second derivatives in a Newton-Raphson approach. Robust estimates of standard errors about the estimators are also provided. Tests of hypotheses are based on a modification of the score test, which allows the assumption of multivariate normality to be relaxed. Conditional goodness-of-fit statistics are proposed that can be used to examine the fit of separate pedigrees to the overall model. This robust approach for estimating the standard errors for variance components by conditioning on the proband's phenotype will allow general inferences to be made from the analysis of families ascertained through probands with extreme or unusual phenotypes and should be most appropriate for studying many physiological traits that may be intrinsically nonnormal.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Beaty TH,Liang KYdoi
10.1002/gepi.1370040305subject
Has Abstractpub_date
1987-01-01 00:00:00pages
203-10issue
3eissn
0741-0395issn
1098-2272journal_volume
4pub_type
杂志文章abstract::This paper summarizes the analyses by participants in the insulin-dependent diabetes mellitus (IDDM) component of Genetic Analysis Workshop 5 (GAW5). The data were obtained from 94 families with two or more IDDM sibs. Topics treated in the Workshop analysis included the following: methods for detecting associations an...
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journal_title:Genetic epidemiology
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abstract::Several methods have been proposed to increase power in rare variant association testing by aggregating information from individual rare variants (MAF < 0.005). However, how to best combine rare variants across multiple ethnicities and the relative performance of designs using different ethnic sampling fractions remai...
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20165
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370100628
更新日期:1993-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s571
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.22083
更新日期:2017-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20493
更新日期:2010-05-01 00:00:00
abstract::Our group studied the effects of genotyping errors, pedigree errors, and missing data on a wide range of techniques, with a focus on the role of single-nucleotide polymorphisms (SNPs). Half of our group used simulated data, and half of our group used data from the Collaborative Study on the Genetics of Alcoholism (COG...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20120
更新日期:2005-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20201
更新日期:2007-04-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s266
更新日期:2001-01-01 00:00:00
abstract::Genes with imprinting (parent-of-origin) effects express differently when inheriting from the mother or from the father. Some genes for development and behavior in mammals are known to be imprinted. We developed parametric linkage analysis that accounts for imprinting effects for continuous traits, implementing it in ...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20321
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:1984-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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