Abstract:
:The potential of genome-wide association analysis can only be realized when they have power to detect signals despite the detrimental effect of multiple testing on power. We develop a weighted multiple testing procedure that facilitates the input of prior information in the form of groupings of tests. For each group a weight is estimated from the observed test statistics within the group. Differentially weighting groups improves the power to detect signals in likely groupings. The advantage of the grouped-weighting concept, over fixed weights based on prior information, is that it often leads to an increase in power even if many of the groupings are not correlated with the signal. Being data dependent, the procedure is remarkably robust to poor choices in groupings. Power is typically improved if one (or more) of the groups clusters multiple tests with signals, yet little power is lost when the groupings are totally random. If there is no apparent signal in a group, relative to a group that appears to have several tests with signals, the former group will be down-weighted relative to the latter. If no groups show apparent signals, then the weights will be approximately equal. The only restriction on the procedure is that the number of groups be small, relative to the total number of tests performed.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Roeder K,Devlin B,Wasserman Ldoi
10.1002/gepi.20237subject
Has Abstractpub_date
2007-11-01 00:00:00pages
741-7issue
7eissn
0741-0395issn
1098-2272journal_volume
31pub_type
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