Abstract:
:Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log10IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Page GP,Wilcox MA,Occhiuto J,Adak S,Neuberg D,Bajorunaite R,George Vdoi
10.1002/gepi.2001.21.s1.s312subject
Has Abstractpub_date
2001-01-01 00:00:00pages
S312-6eissn
0741-0395issn
1098-2272journal_volume
21 Suppl 1pub_type
杂志文章abstract::The recurrence risks for an X-linked disease with incomplete penetrance are evaluated for a sib given that an isolated proband (male or female) is affected. The derived formulae are applied to the X-linked form of Alport and fragile X syndromes. ...
journal_title:Genetic epidemiology
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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