Abstract:
:Twin pairs are sometimes included in studies because at least one of them is a proband, and conventionally the analysis of the data is based on the conditional distribution of the co twin given the proband. In the case of more than one proband in each pair, an often used "ad hoc" method of analysis is to allow each twin to act as proband as well as co twin. An example of this is the pro band wise concordance, which is used as an estimate of the case wise concordance under incomplete ascertainment. In this paper, we show that the method of double entry under a regularity condition provides consistent estimates of parameters, but that conventional standard errors as well as a correction suggested by Stevenson et al. will be wrong. Instead, we recommend the use of an easily calculated sandwich estimator. We illustrate the method with twin data from a study of the genetic component in hand eczema.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Hindsberger C,Bryld LEdoi
10.1002/gepi.10253subject
Has Abstractpub_date
2003-11-01 00:00:00pages
225-35issue
3eissn
0741-0395issn
1098-2272journal_volume
25pub_type
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