Abstract:
:Two analytic methods were used in the Problem 2 data set. First, generalized estimating equations (GEE) modelling was developed to adjust for familial correlation in regressions evaluating candidate genes and an environmental factor. Second, the affected-pedigree-member (APM) method was used to identify chromosomal regions of interest and linkage of candidate genes with disease affection status. The GEE method identified C5 (MG1) as important for the quantitative trait Q1 and the corresponding affection status DIS, but the APM method was only suggestive. The GEE method identified C2 (MG2) as important for Q2 but only marginally important for Q1 and not important for DIS.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Bull SB,Chapman NH,Greenwood CM,Darlington GAdoi
10.1002/gepi.1370120633subject
Has Abstractpub_date
1995-01-01 00:00:00pages
729-34issue
6eissn
0741-0395issn
1098-2272journal_volume
12pub_type
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