Risk factors for atherosclerosis in twins.


:We performed multivariate genetic analyses of cardiovascular risk factors from two sets of data on US and Australian female twins. Similar models for body mass index (BMI), serum low density (LDL) and high density (HDL) lipoproteins, including age as a covariate, were fitted successfully to both groups. These suggested that BMI, or genes responsible for a significant proportion of the variance of BMI, explained correlations between lipid subfractions, as well as those between blood pressure and lipid subfractions, especially HDL.


Genet Epidemiol


Genetic epidemiology


Duffy DL,O'Connell DL,Heller RF,Martin NG




Has Abstract


1993-01-01 00:00:00












  • Accounting for population stratification in DNA methylation studies.

    abstract::DNA methylation is an important epigenetic mechanism that has been linked to complex diseases and is of great interest to researchers as a potential link between genome, environment, and disease. As the scale of DNA methylation association studies approaches that of genome-wide association studies, issues such as popu...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Barfield RT,Almli LM,Kilaru V,Smith AK,Mercer KB,Duncan R,Klengel T,Mehta D,Binder EB,Epstein MP,Ressler KJ,Conneely KN

    更新日期:2014-04-01 00:00:00

  • Testing for association in SLE families.

    abstract::Systemic lupus erythematosus (SLE) is a complex disease which is partly determined by genetic factors which influence susceptibility to the disease phenotype. In this association study we try to define the high risk haplotypes which are responsible for this disease, together with other environmental factors. In many o...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Seuchter SA,Knapp M,Hartung K,Coldewey R,Kalden JR,Lakomek HJ,Peter HH,Deicher H,Baur MP

    更新日期:1991-01-01 00:00:00

  • Detecting epistatic interactions contributing to quantitative traits.

    abstract::The restricted partition method (RPM) is a partitioning algorithm for examining multi-locus genotypes as (potentially non-additive) predictors of a quantitative trait. The motivating application was to develop a robust method to examine quantitative phenotypes for epistasis (gene-gene interactions), but the method can...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章,评审


    authors: Culverhouse R,Klein T,Shannon W

    更新日期:2004-09-01 00:00:00

  • Allelic association patterns for a dense SNP map.

    abstract::A dense set of 5,000 SNPs on a 10-Mb region of human chromosome 20 has been typed on samples of African Americans, East Asians, and United Kingdom Caucasians. There are departures from Hardy-Weinberg equilibrium beyond the level at which markers are often discarded because of possible genotyping errors. The observatio...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Weir BS,Hill WG,Cardon LR,SNP Consortium.

    更新日期:2004-12-01 00:00:00

  • Genetic analysis of a complex disease in the presence of an environmental risk factor.

    abstract::The role of a gene in a disease may be hidden by the presence of another risk factor such as an environmental factor. In that case, stratifying the data according to this factor strengthens power to detect linkage or association. We followed this strategy on the simulated data provided by GAW11. The transmission/diseq...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Eichenbaum-Voline S,Baur MP,Knapp M

    更新日期:1999-01-01 00:00:00

  • PreCimp: Pre-collapsing imputation approach increases imputation accuracy of rare variants in terms of collapsed variables.

    abstract::Imputation is widely used for obtaining information about rare variants. However, one issue concerning imputation is the low accuracy of imputed rare variants as the inaccurate imputed rare variants may distort the results of region-based association tests. Therefore, we developed a pre-collapsing imputation method (P...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Kim YJ,Lee J,Kim BJ,T2D-Genes Consortium.,Park T

    更新日期:2017-01-01 00:00:00

  • Apolipoprotein E-epsilon 4 allele and familial risk in Alzheimer's disease.

    abstract::Recent studies have found an association between presence of apolipoprotein E (APOE) epsilon 4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the epsilon 4 allele with the relatives of A...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Li G,Silverman JM,Altstiel LD,Haroutunian V,Perl DP,Purohit D,Birstein S,Lantz M,Mohs RC,Davis KL

    更新日期:1996-01-01 00:00:00

  • Apolipoprotein E phenotype, arterial disease, and mortality among older women: the study of osteoporotic fractures.

    abstract::This study is an investigation of the relationship between apolipoprotein E (apoE) phenotype, arterial disease, and mortality in a group of women (n = 1,751) aged 65 years and older enrolled in the Study of Osteoporotic Fractures. Crude mortality rates were highest among women with the 4-3 and 4-4 phenotypes but age-a...

    journal_title:Genetic epidemiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Vogt MT,Cauley JA,Kuller LH

    更新日期:1997-01-01 00:00:00

  • Affected relative pairs and simultaneous search for two-locus linkage in the presence of epistasis.

    abstract::It is commonly believed that multiple interacting genes increase the susceptibility of genetically complex diseases, yet few linkage analyses of human diseases scan for more than one locus at a time. To overcome some of the statistical and computational limitations of a simultaneous search for two disease susceptibili...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Schaid DJ,McDonnell SK,Carlson EE,Thibodeau SN,Ostrander EA,Stanford JL

    更新日期:2007-07-01 00:00:00

  • Sequencing and imputation in GWAS: Cost-effective strategies to increase power and genomic coverage across diverse populations.

    abstract::A key aim for current genome-wide association studies (GWAS) is to interrogate the full spectrum of genetic variation underlying human traits, including rare variants, across populations. Deep whole-genome sequencing is the gold standard to fully capture genetic variation, but remains prohibitively expensive for large...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Quick C,Anugu P,Musani S,Weiss ST,Burchard EG,White MJ,Keys KL,Cucca F,Sidore C,Boehnke M,Fuchsberger C

    更新日期:2020-09-01 00:00:00

  • Comparison of empirical strategies to maximize GENEHUNTER lod scores.

    abstract::We compare four strategies for finding the settings of genetic parameters that maximize the lod scores reported in GENEHUNTER 1.2. The four strategies are iterated complete factorial designs, iterated orthogonal Latin hypercubes, evolutionary operation, and numerical optimization. The genetic parameters that are set a...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Chen CH,Finch SJ,Mendell NR,Gordon D

    更新日期:1999-01-01 00:00:00

  • An efficient study design to test parent-of-origin effects in family trios.

    abstract::Increasing evidence has shown that genes may cause prenatal, neonatal, and pediatric diseases depending on their parental origins. Statistical models that incorporate parent-of-origin effects (POEs) can improve the power of detecting disease-associated genes and help explain the missing heritability of diseases. In ma...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Yu X,Chen G,Feng R

    更新日期:2017-11-01 00:00:00

  • Biochemical intermediates in alpha 1-antitrypsin deficiency: residual family resemblance for total alpha 1-antitrypsin, oxidized alpha 1-antitrypsin, and immunoglobulin E after adjustment for the effect of the Pi locus.

    abstract::alpha 1-antitrypsin (alpha 1 AT) deficiency is variably associated with the development of pulmonary emphysema. To gain insight into the process which begins the Z point mutation at the Protease Inhibitor (Pi) locus and results in the variable development of emphysema, three quantitative phenotypes, including total al...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Silverman EK,Province MA,Campbell EJ,Pierce JA,Rao DC

    更新日期:1990-01-01 00:00:00

  • Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error.

    abstract::The purpose of this work is the development of linear trend tests that allow for error (LTT ae), specifically incorporating double-sampling information on phenotypes and/or genotypes. We use a likelihood framework. Misclassification errors are estimated via double sampling. Unbiased estimates of penetrances and genoty...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Gordon D,Haynes C,Yang Y,Kramer PL,Finch SJ

    更新日期:2007-12-01 00:00:00

  • Multipoint analysis using affected sib pairs: incorporating linkage evidence from unlinked regions.

    abstract::In this paper, we proposed a multipoint method to assess evidence of linkage to one region by incorporating linkage evidence from another region. This approach uses affected sib pairs in which the number of alleles shared identical by descent (IBD) is the primary statistic. This generalized estimating equation (GEE) a...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Liang KY,Chiu YF,Beaty TH,Wjst M

    更新日期:2001-09-01 00:00:00

  • Univariate analysis of dichotomous or ordinal data from twin pairs: a simulation study comparing structural equation modeling and logistic regression.

    abstract::The univariate analysis of categorical twin data can be performed using either structural equation modeling (SEM) or logistic regression. This paper presents a comparison between these two methods using a simulation study. Dichotomous and ordinal (three category) twin data are simulated under two different sample size...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Ramakrishnan V,Meyer JM,Goldberg J,Henderson WG

    更新日期:1996-01-01 00:00:00

  • Genetic epidemiology of breast cancer: segregation analysis of 389 Icelandic pedigrees.

    abstract::A genetic epidemiologic investigation of breast cancer involving 389 breast cancer pedigrees including information on 14,721 individuals from the Icelandic population-based cancer registry is presented. Probands were women born in or after 1920 and reported to have breast cancer in the cancer registry. The average age...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Baffoe-Bonnie AB,Beaty TH,Bailey-Wilson JE,Kiemeney LA,Sigvaldason H,Olafsdóttir G,Tryggvadóttir L,Tulinius H

    更新日期:2000-01-01 00:00:00

  • Comparison of the QTDT analysis for IgE in the CSGA data set.

    abstract::Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Page GP,Wilcox MA,Occhiuto J,Adak S,Neuberg D,Bajorunaite R,George V

    更新日期:2001-01-01 00:00:00

  • Availability of schizophrenic patients and their families for genetic linkage studies: findings from the Maryland epidemiology sample.

    abstract::It has been suggested that collections of affected sib pairs, or their nuclear families, may be an efficient method for screening for genetic linkages in schizophrenia. We present the data collected in five years from 15 hospitals in the state of Maryland in an effort to determine if such a collection scheme will be f...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Pulver AE,Bale SJ

    更新日期:1989-01-01 00:00:00

  • Linkage disequilibrium structure and its impact on the localization of a candidate functional mutation.

    abstract::We have used the unblinded MG1/Q1 Genetic Analysis Workshop 12 simulated data as a model system for investigating the use of linkage disequilibrium structure and simple genotype-phenotype associations to identify candidate functional mutations within a gene of interest. Analysis of the pattern of pairwise linkage dise...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Huang Q,Morrison AC,Boerwinkle E

    更新日期:2001-01-01 00:00:00

  • Meta-analysis by combining p-values: simulated linkage studies.

    abstract::Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were c...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章,meta分析


    authors: Guerra R,Etzel CJ,Goldstein DR,Sain SR

    更新日期:1999-01-01 00:00:00

  • TDT with covariates and genomic screens with mod scores: their behavior on simulated data.

    abstract::We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the popula...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Rice JP,Neuman RJ,Hoshaw SL,Daw EW,Gu C

    更新日期:1995-01-01 00:00:00

  • Segregation analysis of autosomal dominant polycystic kidney disease.

    abstract::The results of classical segregation analysis on 159 families with polycystic kidney disease (PKD) are presented. It had been previously estimated that about 95% of autosomal dominant PKD (ADPKD) families have PKD1, the gene localized to chromosome 16p. The main purpose of the study was to determine if PKD shows any s...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Dobin A,Kimberling WJ,Pettinger W,Bailey-Wilson JE,Shugart YY,Gabow P

    更新日期:1993-01-01 00:00:00

  • Effect of linkage disequilibrium between markers in linkage and association analyses.

    abstract::Contributions to Group 17 of the Genetic Analysis Workshop 15 considered dense markers in linkage disequilibrium (LD) in the context of either linkage or association analysis. Three contributions reported on methods for modeling LD or selecting a subset of markers in linkage equilibrium to perform linkage analysis. Wh...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Dupuis J,Albers K,Allen-Brady K,Cho K,Elston RC,Kappen HJ,Tang H,Thomas A,Thomson G,Tsung E,Yang Q,Zhang W,Zhao K,Zheng G,Ziegler JT

    更新日期:2007-01-01 00:00:00

  • Testing Hardy-Weinberg equilibrium using mother-child case-control samples.

    abstract::Genetic association studies of obstetric complications may genotype case and control mothers, or their respective newborns, or both case-control mothers and their children. The relatively high prevalence of many obstetric complications and the availability of both maternal and offspring's genotype data have provided m...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Chen J,Zheng H,Wilson ML,Kraft P

    更新日期:2009-09-01 00:00:00

  • Power of the linkage test for a heterogeneous disorder due to two independent inherited causes: a simulation study.

    abstract::We have conducted a simulation study in small pedigrees to investigate the power to detect linkage and heterogeneity for a disorder due to either one of two independent disease loci. We have considered a highly polymorphic marker locus (PIC = 70%) linked to one disease locus and unlinked to the second. The power to de...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Martinez M,Goldin LR

    更新日期:1990-01-01 00:00:00

  • Scope and strategies of genetic epidemiology: analysis of articles published in Genetic Epidemiology, 1984-1991.

    abstract::Genetic epidemiology is a relatively new discipline that seeks to unravel the role of genetic factors and their interactions with environmental factors in the etiology of diseases, using population and family study approaches. To characterize the overall direction and emphasis of research strategies used in this field...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Khoury MJ,Beaty TH,Cohen BH

    更新日期:1993-01-01 00:00:00

  • Trends in prenatal diagnosis of Down syndrome and other autosomal trisomies in Scotland 1990 to 1994, with associated cytogenetic and epidemiological findings.

    abstract::The present report summarizes findings on 670 cases of autosomal trisomy diagnosed in Scotland, with actual or expected dates of delivery in 1990 to 1994 inclusive. Cases were notified by cytogenetic service laboratories. There were 277 prenatal and 369 postnatal diagnoses and 24 spontaneous losses. Excluding the latt...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Carothers AD,Boyd E,Lowther G,Ellis PM,Couzin DA,Faed MJ,Robb A

    更新日期:1999-01-01 00:00:00

  • Explorative two-locus linkage analysis suggests a multiplicative interaction between the 7q32 and 16p13 myoclonic seizures-related photosensitivity loci.

    abstract::In traits suspected to be governed by at least two loci, linkage analysis incorporating the joint action of both loci may improve the power to detect linkage, increase the precision of estimating locus positions and provide insight into the underlying etiological mechanism. Recently, we mapped two susceptibility loci ...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Pinto D,Kasteleijn-Nolst Trenité DG,Cordell HJ,Mattheisen M,Strauch K,Lindhout D,Koeleman BP

    更新日期:2007-01-01 00:00:00

  • Identification of gene-gene interactions in the presence of missing data using the multifactor dimensionality reduction method.

    abstract::Gene-gene interaction is believed to play an important role in understanding complex traits. Multifactor dimensionality reduction (MDR) was proposed by Ritchie et al. [2001. Am J Hum Genet 69:138-147] to identify multiple loci that simultaneously affect disease susceptibility. Although the MDR method has been widely u...

    journal_title:Genetic epidemiology

    pub_type: 杂志文章


    authors: Namkung J,Elston RC,Yang JM,Park T

    更新日期:2009-11-01 00:00:00