Abstract:
:We combined the five chromosome 18 bipolar affective disorder data sets provided by GAW10, totaling 185 families with 3,394 individuals, and performed analysis of differential parental transmission and chromosome 18 marker allele sharing in families with transmission through fathers vs those through mothers. Results indicated a significant excess of maternal transmission of bipolar disorder. All pedigrees were then broken into nuclear families and affected sib-pair linkage analyses performed on the marker, D18S37. There was significant linkage in the data overall, as well as in each subgroup of paternal, maternal and unknown parental transmission nuclear families. There were no significant differences in identical-by-descent (IBD) scores among the three transmission subgroups. These findings support an excess of maternal transmission, and linkage between bipolar disorder and marker D18S37. However, our results do not support the previous suggestion that there are differences in chromosome 18 marker allele sharing depending on the transmitting parent.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Lin JP,Bale SJdoi
10.1002/(SICI)1098-2272(1997)14:6<665::AID-GEPI19>subject
Has Abstractpub_date
1997-01-01 00:00:00pages
665-8issue
6eissn
0741-0395issn
1098-2272pii
10.1002/(SICI)1098-2272(1997)14:6<665::AID-GEPI19>journal_volume
14pub_type
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pub_type: 杂志文章
doi:10.1002/gepi.1370100618
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.2001.21.s1.s843
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.20531
更新日期:2010-11-01 00:00:00
abstract::Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identity-by-decent) from affected sib pairs. This is carried out by conditionin...
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更新日期:2004-02-01 00:00:00
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pub_type:
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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