Design of artificial neural network and its applications to the analysis of alcoholism data.

Abstract:

:Artificial neural networks were applied to the alcoholism data to reveal nonlinear relationships between intermediate phenotypes, marker identity-by-descent sharing, and the affection status. A variable number of hidden units were considered to achieve a balance between the minimal mean-squared error and over-fitting of the data. The predictability of the affection status based on intermediate phenotype information (event-related potential 300, monoamine oxidase, and gender) was 65% to 75%, and sensitivity/specificity ranged around 50% to 80%. The IBD approach succeeded in identifying the same marker as previous studies, but also found additional peaks.

journal_name

Genet Epidemiol

journal_title

Genetic epidemiology

authors

Li W,Haghighi F,Falk CT

doi

10.1002/gepi.1370170738

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

S223-8

eissn

0741-0395

issn

1098-2272

journal_volume

17 Suppl 1

pub_type

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