Abstract:
:Genome-wide association studies (GWAS) are a powerful tool for understanding the genetic basis of diseases and traits, but most studies have been conducted in isolation, with a focus on either a single or a set of closely related phenotypes. We describe MetABF, a simple Bayesian framework for performing integrative meta-analysis across multiple GWAS using summary statistics. The approach is applicable across a wide range of study designs and can increase the power by 50% compared with standard frequentist tests when only a subset of studies have a true effect. We demonstrate its utility in a meta-analysis of 20 diverse GWAS which were part of the Wellcome Trust Case Control Consortium 2. The novelty of the approach is its ability to explore, and assess the evidence for a range of possible true patterns of association across studies in a computationally efficient framework.
journal_name
Genet Epidemioljournal_title
Genetic epidemiologyauthors
Trochet H,Pirinen M,Band G,Jostins L,McVean G,Spencer CCAdoi
10.1002/gepi.22202subject
Has Abstractpub_date
2019-07-01 00:00:00pages
532-547issue
5eissn
0741-0395issn
1098-2272journal_volume
43pub_type
杂志文章,meta分析abstract::In this paper, we proposed a multipoint method to assess evidence of linkage to one region by incorporating linkage evidence from another region. This approach uses affected sib pairs in which the number of alleles shared identical by descent (IBD) is the primary statistic. This generalized estimating equation (GEE) a...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1021
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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doi:10.1002/gepi.21740
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20365
更新日期:2009-02-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20602
更新日期:2011-09-01 00:00:00
abstract::Regressive models that incorporate measured variables and assumed genetic parameters were used to detect interactions between gene, research site, and environmental variables in GAW11 Problem 2. Replicates 1 to 5 were used in the analyses. Significant three-way gene x environment x site interactions were seen for all ...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.13701707118
更新日期:1999-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370110108
更新日期:1994-01-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
abstract::This study is an investigation of the relationship between apolipoprotein E (apoE) phenotype, arterial disease, and mortality in a group of women (n = 1,751) aged 65 years and older enrolled in the Study of Osteoporotic Fractures. Crude mortality rates were highest among women with the 4-3 and 4-4 phenotypes but age-a...
journal_title:Genetic epidemiology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1997-01-01 00:00:00
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journal_title:Genetic epidemiology
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20626
更新日期:2011-12-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(200004)18:4<293::AID-GEPI3
更新日期:2000-04-01 00:00:00
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journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1997)14:6<605::AID-GEPI9>3
更新日期:1997-01-01 00:00:00
abstract::We propose methods to construct meiotic gene maps while controlling the probability of a decision-error. First, a single step gene ordering procedure is presented whose decision-error probability is bounded above by a prespecified threshold. The bound for the error probability is valid under quite general circumstance...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1999)16:3<274::AID-GEPI4>3
更新日期:1999-01-01 00:00:00
abstract::It is commonly believed that multiple interacting genes increase the susceptibility of genetically complex diseases, yet few linkage analyses of human diseases scan for more than one locus at a time. To overcome some of the statistical and computational limitations of a simultaneous search for two disease susceptibili...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.20223
更新日期:2007-07-01 00:00:00
abstract::A recently developed nonparametric method is a generalization of the transmission disequilibrium test across all alleles of a locus. This approach has been applied to Problem 2 of GAW10 and has been extended to explore the combined contribution of neighboring loci for chromosomes 1, 5, and 8. When applied to the chrom...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2272(1997)14:6<857::AID-GEPI49>
更新日期:1997-01-01 00:00:00
abstract::Smalley et al. [(1992) Genet Epidemiol 9:333-345] found evidence of a mixture of two distributions in memory performance among offspring of patients with dementia of the Alzheimer type (DAT), suggesting that these groups reflect genotypic subgroups of carriers and non-carriers of a putative DAT gene. One prediction of...
journal_title:Genetic epidemiology
pub_type: 杂志文章
doi:10.1002/gepi.1370110506
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.21826
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gepi.20255
更新日期:2008-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:2003-12-01 00:00:00
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更新日期:2011-11-01 00:00:00
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更新日期:2001-01-01 00:00:00
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